Ppt on meta analysis journal club

UNM FM Journal Club A New Paradigm and Example July 16, 2014.

figure out what type of question it is. Type of Study QuestionStudy Design Intervention/TherapySystematic Review/Meta Analysis Randomized (efficacy) Cohort study (effectiveness) Etiology/HarmCohort Case Control Case Series Diagnostic TestingCohort Cross-/  www.thecochranelibrary.com/view/0/index. html www.thecochranelibrary.com/view/0/index. html Other sources  ACP Journal Club  annals.org/journalclub.aspx annals.org/journalclub.aspx  Evidence Updates  plus.mcmaster.ca/EvidenceUpdates/ plus.mcmaster.ca/


Low 25-Hydroxyvitamin D and Risk of Type 2 Diabetes: A Prospective Cohort Study and Meta-analysis S. Afzal, S.E. Bojesen, and B.G. Nordestgaard February.

We observed an increasing risk of type 2 diabetes with decreasing plasma 25(OH)D concentrations. These findings were confirmed in a meta-analysis of prospective studies  Potential limitations: Caucasian population only and diagnoses may underestimate incidence of diabetes  Strengths: up to 29/ you for participating in this month’s Clinical Chemistry Journal Club. Additional Journal Clubs are available at www.clinchem.org Download the free Clinical Chemistry app on iTunes for additional content! Follow us


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2010 年 1 月 14 日 8:30-8:55 8階 医局 The Emerging Risk Factors Collaboration. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis/-specific log e risk ratios were combined by use of multivariate random-effects meta-analysis. The adjustments were age, sex, and study only (A); age, /


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2011 年 2 月 17 日 8:30/To review the association between current enterovirus infection diagnosed with molecular testing and development of autoimmunity or type 1 diabetes. Design: Systematic review and meta-analysis of observational studies, analysed with random effects models. Data sources: PubMed (until May 2010) and Embase (until May 2010), no language /


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2009 年7月9日 8:30-8:55 8階 医局 Mauer M, Zinman B, Gardiner R, Suissa S/. 2009 Jul 2;361(1):40-51. Li S, Shin JJ, Ding EL, van Dam RM. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2009 Jul 8;302(2):179-88. Review. From the Departments of Pediatrics (M.M., A.S., T.S.) and Medicine (M.M.), University of Minnesota/


Www.aodhealth.org1 Journal Club Alcohol, Other Drugs, and Health: Current Evidence November-December 2012.

www.aodhealth.org1 Journal Club Alcohol, Other Drugs, and Health: Current Evidence November-December 2012 Featured Article Behavioral Counseling after Screening for Alcohol Misuse in Primary Care: A Systematic Review and Meta-analysis for the U.S. Preventive/of behavioral counseling interventions in people with alcohol use disorders. www.aodhealth.org4 Study Design Systematic review and meta-analysis of 23 controlled trials of at least 6 months ’ duration that: –enrolled persons with alcohol misuse /


A warm welcome to today’s Journal Club We aim to start promptly at 10am Your chair is Chris Skinner Professor of Statistics, London School of Economics.

of Economics and Political Science Journal of the Royal Statistical Society, Series C, 63, pp. 321–341 (2013) RSS Journal Club Webinar, 20.11.2014/models? RSS webinar November 20th 2014 Previous comparisons Machine learning domain: Large meta study (Jamain & Hand, 2008). Large comparative studies on ML repository data/ all data sets, overall good (across widely different data sets): Linear discriminant analysis Tree classifier 6 RSS webinar November 20th 2014 Dimensions of predictive performance 3 dimensions/


The contribution of the archival principles to a meta-science methodology for digital heritage Mariella Guercio Sapienza Università.

with a multidisciplinary approach an assumption and its implications: meta-science “The Metascience Expression (ME) language has / of Computing, The International Journal of science in society. 1: 133-143, http:/// of Transdisciplinarity, http://nicol.club.fr/ciret/english/charten.htm andhttp://nicol.club.fr/ciret/english/charten.htm/ they have? which methodological tools could support such analysis other than and beyond an historical reconstruction based on/


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2016 年 1 月 7 日 8:30-8:55 8階 医局 /to mg/dL, divide by 0.0259. ‡ To convert values to mg/dL, divide by 0.0113. Zaccardi and colleagues (5) conducted a network meta-analysis of randomized trials that could yield, directly or indirectly, estimates of comparative efficacy between once-weekly glucagon-like peptide-1 receptor agonists. They found these trials/


Journal Club Mallory McClester, PGY-4 August 16, 2013.

Journal Club Mallory McClester, PGY-4 August 16, 2013 Objectives  Review the article contents  Discussion of article critically  Feedback from the group  Final conclusions Background  / Beckett N, Peters R, et al. Treatment of Hypertension in Patients 80 Years of Age and Older. New England Journal of Medicine. 2008; 358(18): 1887-1898.  Woolcott JC, Richardson KJ, Wiens MO, et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med. 2009;169(21):1952-1960. /


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2016 年 9 月 1 日 8:30-8:55 8階 医局 / retinopathy (DR), as a complication of the precipitous trends in global diabetes, is fundamental for health planning purposes. RESEARCH DESIGN AND METHODS The meta-analysis of published population studies from 1990 to 2012 for the Global Burden of Disease Study 2010 (GBD) yielded estimated global regional trends in DR /


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2013 年 12 月 19 日 8:30-8:55 8階 医局 The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects). Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis/) and stroke (B) p values were meta-regression p values between groups. Results are /


Journal Club 12/02 Dr Stephen Newell. Current Problems in Pharmacovigilance October 2002 Safety update on long-term HRT.

Journal Club 12/02 Dr Stephen Newell Current Problems in Pharmacovigilance October 2002 Safety update on long-term HRT Coronary heart disease “The anticipated / users has been confirmed.” HRT and breast cancer (from Bandolier) K Nanda et al. Hormone replacement therapy and the risk of death from breast cancer: a meta-analysis. American Journal of O & G 2002, 186: 325-334. Systematic review using several electronic databases, reference reviews, and contacts with experts and HRT-manufacturing companies for any/


Www.metcardio.org SURVIVING THE PEER REVIEW PROCESS Giuseppe Biondi Zoccai Division of Cardiology, University of Turin, Turin, Italy Meta-analysis and.

Division of Cardiology, University of Turin, Turin, Italy Meta-analysis and Evidence-based medicine Training in Cardiology (METCARDIO), Ospedaletti/Broadens participation and dialogue www.metcardio.org PARAPHRASING GROUCHO I would never enter into a club that would accept me as a member… Groucho Marx, 1980-1977 www.metcardio.org/ methodology Manuscript can be judged as low, mid, high, or top priority Some journals (e.g. the Journal of Cardiovascular Medicine) use scores, e.g. ranging from 0 to 100, with/


Journal Club FLUshing Out the Evidence for Neuraminidase Inhibitors in the Treatment of InFLUenza Manish Khullar BSc.(Pharm) Sukhjinder Sidhu BSc.(Pharm)

Journal Club FLUshing Out the Evidence for Neuraminidase Inhibitors in the Treatment of InFLUenza Manish Khullar BSc.(Pharm) Sukhjinder Sidhu BSc.(Pharm) Interior Health Pharmacy Residents Infectious Disease Rotation May 1, 2014 2014 The Controversy Influenza Signs/symptoms – Fever – Sore throat – Rhinitis – Nonproductive cough – Myalgias – Malaise Complications – Secondary infections (bacterial pneumonia, otitis media) – Hospitalizations – Death How does Oseltamivir Work? Our PICO DesignMeta-analysis /


VUR, UTI, and Antibiotic Prophylaxis How to Use an Article About Therapy or Prevention Journal Club Amy K Evans PGY2 August 15, 2006.

VUR, UTI, and Antibiotic Prophylaxis How to Use an Article About Therapy or Prevention Journal Club Amy K Evans PGY2 August 15, 2006 The Case Kali is a 14mo female who presents to WRAMC ED with fever /help me in caring for my patients? JAMA 1994;271:59-63. 13. Lee RS et.al. Antenatal hydronephrosis as a predictor of postnatal outcome: a meta- analysis. Pediatrics 2006;118(2):586-593. 14. Penido Silva JM et.al. Clinical course of prenatally detected primary vesicoureteral reflux. Pediatr Nephrol 2006;21:86-91/


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2009 年 4 月 23 日 8:30-8:55 8階 医局 /and platelet function) regardless of pretreatment levels. Design We quantified the efficacy and adverse effects of the proposed formulation from published meta-analyses of randomised trials and cohort studies and a meta- analysis of 15 trials of low dose (50-125 mg/day) aspirin. BMJ VOLUME 326 28 JUNE 2003 bmj.com 1419/


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2011 年 5 月 19 日 8:30-8:55 8階 医局 Thangaratinam S, Tan A, Knox E, Kilby MD, Franklyn J, Coomarasamy A. Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis/on pregnancy outcomes in this group of women. Design Systematic review and meta-analysis. Data sources Medline, Embase, Cochrane Library, and SCISEARCH (inception-/


Intimate Partner Violence During Pregnancy and the Risk for Adverse Infant Outcomes: A Systematic Review and Meta-Analysis Donovan BM, Spracklen CN, Schweizer.

ly/10VaiRZ For further information: – Follow @BlueJCHost@BlueJCHost – Go to http://bluejc.orghttp://bluejc.org – See BJOG Journal Club section at http://www.bjog.org/ http://www.bjog.org/ Clinical Scenario A nulliparous woman visits her midwife at 13/for-gestational age (SGA): birth weight <10 th percentile for a given gestational age Study DesignSystematic review and meta-analysis of observational studies Background In your practice, how prevalent is IPV during pregnancy? How does this prevalent compared to/


 Exercise and Vitamin D in Fall Prevention Among Older Women Journal Club, June 2016 Theresa Drallmeier and Tu Dao.

 Exercise and Vitamin D in Fall Prevention Among Older Women Journal Club, June 2016 Theresa Drallmeier and Tu Dao Background  Falls are the leading cause of fracture and unintentional injury in/ components) prevent falls as well as injuries related to falls  Less clear evidence for vitamin D supplementation Vitamin D in Fall Prevention  2010 meta-analysis: vitamin D decreased falls (RR 0.83, 95% CI 0.77-0.89)  2012: USPSTF recommended vitamin D supplementation (and exercise) for fall prevention/


Vitamin D Supplementation in Healthy Children and Adolescents SCH Journal Club Rachel Harrison 20 th September 2012.

Vitamin D Supplementation in Healthy Children and Adolescents SCH Journal Club Rachel Harrison 20 th September 2012 Background Vit D plays an essential role in maintaining good health: –calcium / in children and adolescents To determine if effects of supplementation vary with factors such as vitamin D dose and status Methods Systematic review and meta-analysis RCT’s of vitamin D supplementation including a placebo control Children and adolescents aged 1 month to <20 years Identification of papers –Databases /


Copyright restrictions may apply JAMA Pediatrics Journal Club Slides: Pharmacologic Treatment of Pediatric Headaches El-Chammas K, Keyes J, Thompson N,

may apply JAMA Pediatrics Journal Club Slides: Pharmacologic Treatment of Pediatric Headaches El-Chammas K, Keyes J, Thompson N, Vijayakumar J, Becher D, Jackson JL. Pharmacologic treatment of pediatric headaches: a meta-analysis. JAMA Pediatr. Published / and adverse effect profile. Study Objective –To assist in clinical decision-making by conducting a meta-analysis to assess comparative effectiveness and adverse effects of available agents for prophylactic treatments. Introduction Copyright restrictions/


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2012 年 3 月 29 日 8:30-8:55 8階 医局 Schauer PR, /61.7% / 78.5% 高脂血症改善率 1 ) 96.90%58.90%79.30% 睡眠時無呼吸改善率 1 ) 94.80%68%83.60% 1) Bariatric surgery: a systematic review and meta-analysis. Buchwald H, Avidor Y, Braunwald E et al: JAMA. 2004 14:1724-37 2) Brazil Sao Paulo Gastro Obeso Center での同一スタッフによる腹腔鏡下胃バイパス 術 :2012 人、腹腔鏡下バンディング術 1174 人の検討( 2005 年 IFSO 発表) A/


Journal Club Lei Zhang PGY 3 7/16/09. Case 55 y.o. F, PMH HTN, DM, TIA, and diverticulosis Had multitple diverticulitis, lower GIB in the past Scheduled.

Journal Club Lei Zhang PGY 3 7/16/09 Case 55 y.o. F, PMH HTN, DM, TIA, and diverticulosis Had multitple / of 8 perioperative days Conclusions: Perioperative metoprolol did not significantly affect mortality and cardiac morbidity Perioperative Beta Blocker use BMJ, 2006 Devereaux & colleague published a meta- analysis of randomized controlled trials in non-cardiac surgery pts β blockers might prevent major cardiovascular events but increase the risk of hypotension & bradycardia Peri-operative Use/


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2013 年 2 月 14 / Objective To compare the long term efficacy and adverse events of dual blockade of the renin-angiotensin system with monotherapy. Design Systematic review and meta-analysis. Data sources PubMed, Embase, and the Cochrane central register of controlled trials, January 1990 to August 2012. Study selection Randomised controlled trials /


Journal Club 亀田メディカルセンター 糖尿病内分泌内科 Diabetes and Endocrine Department, Kameda Medical Center 松田 昌文 Matsuda, Masafumi 2008 年2月 14 日 8:20-8:50 B 棟8階 カンファレンス室.

Journal Club 亀田メディカルセンター 糖尿病内分泌内科 Diabetes and Endocrine Department, Kameda Medical Center 松田 昌文 Matsuda, Masafumi 2008 年2月 14 日 8:20-8:50 B 棟8階 カンファレンス室 TOPICS 糖尿病腎症による透析患者が / bodyweight, expressed as increased body-mass index (BMI), is associated with the risk of some common adult cancers. We did a systematic review and meta-analysis to assess the strength of associations between BMI and different sites of cancer and to investigate differences in these associations between sex and ethnic groups. Background/


Journal Club – Chronic illness

Journal Club – Chronic illness Hypertension Diabetes Lipids Hypertension HOT study - Hypertension Optimal Study - Lancet 1998;351:1755 - 18,790 patients from 26 countries (Europe, N. & S. / 4S study 2) CARE study 3) LIPID study 4) VA-HIT Primary prevention studies: 1) Helsinki heart study 2)WOSCOPS 3) AFCAPS/TexCAPS 4) BMJ –meta-analysis Scandinavian Simvastatin Survival Study Lancet 1994;344:1383-89 4444 patients, age 35-70, all had ischaemic heart disease, randomised to placebo or Simvastatin 20mg T.Chol=5/


USING LARGE SCALE LOG ANALYSIS TO UNDERSTAND HUMAN BEHAVIOR Jaime Teevan, Microsoft ReseachJITP 2011.

 Do we lose marginalia with digital documents?  Internet exposes information experiences  Meta-data, annotations, relationships  Large-scale information usage data  Change in focus With/xxx clubs in seattle10:14 pm 5/15/11142039 sex videos1:49 am 5/16/11142039 Query typology Query behavior Long term trends Uses of Analysis Ranking/ in clicks [Teevan et al. 2008]  Measure: Click entropy  Low if no variation journal of information…  High if lots of variation jitp Which Has Less Variation in Clicks?  /


Www.alcoholandhealth.org1 Journal Club Alcohol and Health: Current Evidence January-February 2006.

.org1 Journal Club Alcohol and Health: Current Evidence January-February 2006 www.alcoholandhealth.org2 Featured Article Alcohol has no effect on hepatitis C virus replication: a meta-analysis Anand BS, et al. Gut. 2005;54:1468-1472. www.alcoholandhealth.org3 Study Objective To examine whether… alcohol stimulates replication of the hepatitis C virus (HCV) www.alcoholandhealth.org4 Study Design Systematic review and meta-analysis of 14/


Journal Club November 2014 By Sourabh Chand ST6. What we know Pentoxifylline – Non-selective phosphodiesterase inhibitor Prevents cAMP inactivation and.

Journal Club November 2014 By Sourabh Chand ST6 What we know Pentoxifylline – Non-selective phosphodiesterase inhibitor Prevents cAMP inactivation and /drug is stopped? What about those with early CKD stages or microalbuminuria (rather than nephrotic range) Future Avoidance of many single centre studies and subsequent meta-analysis – For RCT, double-blinded, placebo controlled, prospective, multi-centred study – Investigating different ethnic groups – Further profile of the mechanistic parameters – inc/


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2012 年 5 月 24 日 8:30-8:55 8階 医局 Cholesterol Treatment Trialists Ctt Collaborators. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis/ at low risk of vascular events remain uncertain. Methods This meta-analysis included individual participant data from 22 trials of statin versus control/


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2010 年6月3日 8:30-8:55 8階 医局 Jun M, Foote C, Lv J, Neal B, Patel A, Nicholls SJ, Grobbee DE, Cass A, Chalmers J, Perkovic V. Effects of fibrates on cardiovascular outcomes: a systematic review and meta- analysis/ on cardiovascular risk. We undertook a systematic review and meta-analysis to investigate the effects of fibrates on major clinical outcomes/


Journal Club Britni Fabacher Hebert, PGY 4. Angiotensin Blockade in the Perioperative Period  Case Presentation  Brief Review of Angiotensin Blockage.

Journal Club Britni Fabacher Hebert, PGY 4 Angiotensin Blockade in the Perioperative Period  Case Presentation  Brief Review of Angiotensin Blockage  Medications /infarction  Did not show the refractory nature of said hypotension discussed in the literature (all episodes responded to ephedrine) Coriat et al, 1994 Rosenman et al  Meta- Analysis by the Mayo Clinic in 2008  Searched 7 major databases for articles from 1981 – 2006  Inclusion Criteria:  Prospective cohort or controlled trials  Enrolling /


Antenatal magnetic resonance imaging (MRI) versus ultrasound for predicting neonatal macrosomia: a systematic review and meta-analysis Malin GL

/1Cuz8MZhttp://linkd.in/1Cuz8MZ – Explore our blog:http://bluejournalclub.wordpress.com/http://bluejournalclub.wordpress.com/ – See BJOG Journal Club: http://www.bjog.org/http://www.bjog.org/ Scenario A midwife referred an African-Caribbean woman at 33 weeks/ (Reference standard) Birthweight >4000 g, >4500 g, >90th or >95th centile Study DesignSystematic review and meta-analysis of diagnostic accuracy studies Figure 1: PRISMA Flow chart Study selection process for systematic review of the diagnostic accuracy/


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2015 年 6 月 18 日 8:30-8:55 8階 医局 Blonde L/Ferrucci L, Gussekloo J, Williams GR, Walsh JP, Jüni P, Aujesky D, Rodondi N; Thyroid Studies Collaboration. Subclinical thyroid dysfunction and fracture risk: a meta-analysis. JAMA. 2015 May 26;313(20):2055-65. doi: 10.1001/jama.2015.5161. Nature Reviews Endocrinology 8, 728-742 The N-terminal amino acid sequence /


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2015 年 11 月 12 /1.15 ( 95 % CI, 1.14 - 1.16 )、心血管死 1.14 ( 95 % CI, 1.13 - 1.15 )だった。年齢、 血糖コントロール、腎合併症の重症度別にみると リスクが低いグループもあった。 http://www.m3.com/clinical/journal/15965 A meta-analysis from University of California, Los Angeles reports the following weight loss at 36 months Biliopancreatic diversion - 53 kg Roux-en-Y gastric bypass (RYGB) - 41 kg Open - 42/


Www.aodhealth.org1 Journal Club Alcohol, Other Drugs, and Health: Current Evidence July–August 2014.

www.aodhealth.org1 Journal Club Alcohol, Other Drugs, and Health: Current Evidence July–August 2014 Featured Article Acamprosate and Naltrexone: Similar Efficacy for Reducing / Study Objective To determine the harms and benefits of medications for the treatment of alcohol use disorder in adults. www.aodhealth.org4 Study Design Systematic review and meta-analysis. Studies were double-blind randomized controlled trials (RCTs) ≥12 weeks’ duration (n = 122) AND one head-to-head prospective cohort study. –Total /


Oral Dexamethasone for Bronchiolitis: A randomized Trial Journal club 20/2/14 Alansari K et al. Oral dexamethasone for bronchiolitis: a randomised trial.

Oral Dexamethasone for Bronchiolitis: A randomized Trial Journal club 20/2/14 Alansari K et al. Oral dexamethasone for bronchiolitis: a randomised trial. Pediatrics 2013 Oct;132(4):e810-6. /infants 2-12 months Randomised to dex or placebo No difference in scores, admission rates, clinical outcomes ? Benefit combined? Hartling et al 2011 Controversial meta- analysis Accused of selection bias Included children up to 2 yrs Airway Oedema Hypertonic saline Zhang et al, 2013 Hypertonic vs 0.9% saline Infants <2 /


Journal Club Julie Shah, MD Milton S Hershey Medical Center Penn State University.

Journal Club Julie Shah, MD Milton S Hershey Medical Center Penn State University Disclosure ♥I do not have any financial interests with the manufacturer of the products discussed in this presentation Objective ♥Analyze the most current journals regarding diabetes research Differential/Follow-up is planned for 5 years in each trial and is currently complete through 2years in all 4 studies Meta-analysis with four major studies Source of Funding ♥The SPIRIT II, III, and IV trials were funded by Abbott Vascular/


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2011 年 7 月 7 日 8:30-8:55 8階 医局 Mozaffarian / for each period, and all lifestyle factors simultaneously. Cohort-specific and sex-specific results were similar and were pooled with the use of an inverse variance– weighted meta-analysis. * Plus–minus values are means ±SD. Data are based on 20 years of follow- up (1986–2006) in the Nurses’ Health Study (NHS),/


Www.alcoholandhealth.org1 Journal Club Alcohol and Health: Current Evidence July-August 2006.

www.alcoholandhealth.org1 Journal Club Alcohol and Health: Current Evidence July-August 2006 www.alcoholandhealth.org2 Featured Article Effect of oral acamprosate on abstinence / P value for the linear trend in abstinence across the 3 groups was 0.02. www.alcoholandhealth.org16 Is the interaction consistent across studies? A meta-analysis of international studies found that acamprosate improves odds of abstinence. –Patients in these studies were usually abstinent for 5 days and entered the studies directly /


Journal Club 亀田メディカルセンター 糖尿病内分泌内科 Diabetes and Endocrine Department, Kameda Medical Center 松田 昌文 Matsuda, Masafumi 2007 年 10 月 11 日 8:20-8:50 B 棟8階 カンファレンス室.

enough observation times to accurately measure the risk for congestive heart failure and cardiovascular death. A recent meta-analysis showed that patients given rosiglitazone had a higher risk of myocardial infarction than controls; they also had a/ closure by ATP and, when expressed in pancreatic  -cells, causes impaired glucose induced insulin secretion and diabetes. Background Journal club Aug 3, 2006 Leptin → Lean : stop appetite, increase energy exp. (increased sympathetic NS) Insulin → Lean Increase/


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 牧野 佑子 髙嶋 正利 牧野 佑子 髙嶋.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 牧野 佑子 髙嶋 正利 牧野 佑子 髙嶋 正利 /歳以上の未治療または血糖制御不良の 2 型糖尿 病( DM )患者 139 人を対象に、ビルダグリプチ ンによる個別設定 HbA1c 目標値の達成可能性を 無作為化試験で評価( INTERVAL 試験)。達成 率はビルダグリプチン群 52.6 %、プラセボ群 27 %だった。著者らは、 2 型 DM の個別 HbA1c 目標使用の実現可能性が示されたと述べている。 A meta-analysis from University of California, Los Angeles reports the following weight loss at 36 months Biliopancreatic diversion - 53 kg Roux-en-Y gastric bypass (RYGB) /


Article Title Resident Name, MD SVCH6/13/2016 Journal Club.

w PMH of comes to SVCH w CC: MedsHosp.course Objectives of the Journal Club What is already known on this topic Where was it published? In which one of the “Big Five”? Article Title Author names........ Affilitiated institutions… Objectives of the Article Design RCT or cohort studies or meta-analysis Outcome measures Proportional reduction in CAD events and stroke Life years gained Prevalence/


Efficacy and Safety of Epoietin Alfa in Critically Ill Patients NEJM 2007, 357: 965-976 TMR Journal Club October 10, 2007 Katerina Pavenski, MD FRCPC TM.

Efficacy and Safety of Epoietin Alfa in Critically Ill Patients NEJM 2007, 357: 965-976 TMR Journal Club October 10, 2007 Katerina Pavenski, MD FRCPC TM Resident, McMaster University 1 Background Anemia in / harm and costs? Unclear So where does this leave us? Instead of Conclusion R. Zarychanski et al. CMAJ 2007, 177: 725-734 –Meta-analysis identified 9 relevant RCTs (3326 patients) included 3 Corwin’s studies –Epoietin alfa (compared to placebo or no intervention) had no statistically significant /


Developmental outcome at 6.5 years after acidosis in Term Newborns SCH medics Journal Club Thursday 12 th July 2012 Faith Harries.

Developmental outcome at 6.5 years after acidosis in Term Newborns SCH medics Journal Club Thursday 12 th July 2012 Faith Harries Aim To evaluate whether metabolic acidosis at birth in term /noted/reported by 6.5 years of age 12. Do the results of this study fit with other available evidence? YES – systematic review and meta-analysis have shown that a low arterial cord pH showed strong, consistent and temporal associations with clinically important neonatal outcomes that are biologically plausible. (BMJ /


Dr Ghofranipour and Dr Heydarnia

Journal Club Session Presenter: Majid Barati PhD student of Health Education & Promotion, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran Special Thanks of: Dr Ghofranipour and Dr Heydarnia Jemma Todd, Barbara Mullan Authors: Jemma Todd, Barbara Mullan School of Psychology, The University of Sydney, Australia Journal/ variance in intentions, which was more than reported in Armitag(2001) meta-analysis, but less than other studies investigating binge drinking. The strongest independent /


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2014 年 12 月 4 日 8:30-8/ (P=.0037) 2012 動脈硬化疾患予防ガイドライン 563)De Berardis G Sacco M,Strippoli GFM, etal: Aspirin fbr primary prevention of cardiovascular events in people with diabetes: meta, analysis of randomised controled trials BMJ 、 339:b4531,2009 564)Lonn E,Dagenais G Yusuf S, etal: Effects of vitamin E on cardiovascular and microvascular outcomes/


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, / major vascular events, defined as the composite of coronary death, myocardial infarction, stroke, or revascularisation. Analysis was by intention to treat. This study is registered, number ISRCTN48489393. Panel: Research in context Systematic/PubMed, and Scopus, supplemented by hand searches of reference lists of review articles and meta-analyses, identified four trials6–8,11 that had previously estimated the effect of statin /


Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi.

Journal Club 埼玉医科大学 総合医療センター 内分泌・糖尿病内科 Department of Endocrinology and Diabetes, Saitama Medical Center, Saitama Medical University 松田 昌文 Matsuda, Masafumi 2014 年 1 月 29 日 8:30-8:55 8階 医局 STobias DK, Pan A, /Diagnosis of Type 2 Diabetes. The results from the two cohorts (NHS and Health Professionals Follow-up Study) were combined with the use of a fixed-effect meta-analysis. The numbers of person-years were 179,081 for all participants, 79,546 for those who had never smoked, and 97,762 for those who had ever/


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