Ppt on acute lymphoblastic leukemia

Acute lymphoblastic leukemia in children Dragana Janić University Chldrens Hospital, Belgrade, Serbia.

VOD at 20% pts; portal hypertension as a late effect Stanulla M, Schrappe M. Treatment of childhood acute lymphoblastic leukemia. Semin Hematol. 2009;46(1):52-63 Choosing treatment protocol - Serbian experience In 2002, all Serbian centers/ 132:17-22 SCG National Group for ALL IC-BFM 2002 Dragana Janić, National Coordinator Intensive chemotherapy for childhood acute lymphoblastic leukemia: results of the randomized intercontinental trial ALL IC-BFM 2002. Stary J, Zimmermann M, Campbell M, Castillo /

Peg-asparginase in the treatment protocol of Acute Lymphoblastic Leukemia Muhammad Qayash Khan PhD in Zoology Ist Semester 2013.

reduce the toxicity level and drug efficiency in Adult ALL. References Dinndorf PAF et al. 2007. DA drug approval summary: pegaspargase (oncaspar) for the first-line treatment of children with acute lymphoblastic leukemia (ALL). Oncologist. 2007 Aug;12(8):991-8. Dinndorf PAOncologist. AsselinBL,WhitinJC,CoppolaDJ,RuppIP,SallanSE,CohenHJ.Comparativepharmacokineticstudi esofthreeasparaginasepreparations.JClinOncol.1993;11:1780-1786.2 0.AlbertsenBK,JakobsenP,SchroderH,SchmiegelowK,CarlsenNT/

Tata Memorial Hospital

66 0.83 0.49 Hepatosplenomegaly 0.58 0.92 Mediastinal mass 0.32 0.10 CALLA + ACUTE LYMPHOBLASTIC LEUKEMIA CHANGING INCIDENCE OVER 3 DECADES T- ACUTE LYMPHOBLASTIC LEUKEMIA CHANGING INCIDENCE OVER 3 DECADES Frequencies of the major subgroups of Precursor B cell ALL in Indian /1.2 1.6 *Guiterrez MI, et al. J Mol Diagnostics 2005; 7:40-47 x MUMBAI DELHI CHENNAI Childhood Acute Lymphoblastic Leukemia Results of MCP-841 in other Centres Bangalore Trivandrum Jaipur Total number 127 66 49 CR (%) 96 83 90 TRM(%) 2/


thrombocytopenia). Infiltration of body organs (e.g. liver, spleen, lymph nodes, meninges, brain, skin or testes). * Classification of leukemia: 1. Acute Leukemia: Acute lymphoblastic leukemia (ALL): L1 – L3. Acute myeloblastic leukemia: (AML): M0 – M7. 2. Chronic Leukemia: Chronic lymphocytic leukemia (CLL). Chronic myelocytic leukemia (CML). * Etiology of leukemia: 1. Congenital disorder: Down syndrome, Immunodeficiency syndrome. 2. Ionizing radiation: X-ray, radiotherapy. 3. Chemicals: (alkylating agent/

FAB Classification (French, American, British)

, red arrow ) and mature neutrophils CML Univ of Minn, Hematography case 17 CML CGL Crookston collection. Chronic Myelomonocytic Leukemia CGL to AML (Blast Crisis) Crookston collection. Chronic Granulocytic Leukemia transforming into Acute Myeloid Leukemia. Chronic Eosinophilic Leukemia Univ of Minn, Hematography case 35 Chronic eosinophilic leukemia (hypereosinophilic syndrome) Acute Lymphoblastic Leukemia (FAB L1) Univ of Minn, Hematography case 6 B Cell ALL, FAB L1 L1: small cells, scant basophilic/

Acute lymphoblastic leukemia (ALL)

leukocyte count, usually increased, - blood morphology: presence of blast cells 2. Bone marrow morphology - presence of blast cells, - suppression of normal hematopoiesis Acute leukemias - Laboratory findings (2) 3. Cytochemical stains 4. Immunophenotyping 5. Cytogenetics 6. Molecular studies Morphologic subtypes of acute lymphoblastic leukemias (FAB classification) Subtype Morphology Occurrence (%) L1 Small round blasts 75 clumped chromatin L2 Pleomorphic larger blasts 20 clefted nuclei, fine chromatin L3/

(“Acute Lymphoblastic Leukemia in Children” par 1)

(“Acute Lymphoblastic Leukemia in Children” par 1) (“Childhood Acute Lymphoblastic Leukemia Treatment”) “Acute Lymphoblastic Leukemia in Children.” National Cancer Institute. 11 July 2002. 1 March 2009. “Acute Lymphocytic Leukemia: Understanding ALL.” The Leukemia & Lymphoma Society Fighting Blood Cancers. 14 July 2008. 1 March 2009 < http://www.leukemia-lymphoma.org/all_page.adp?item_id=7049>. “Childhood Acute Lymphoblastic Leukemia Treatment.” National Cancer Institute, National Institutes of Health.14 /

Leukemia s Copyright, 1996 © Dale Carnegie & Associates, Inc. The development of Leukemia uncontrolled and accelerated production of haematopoietic stem.

.(itractable pain). Acute leukemia diagnostic algorithm. Lymphoblast/myeloblast Acute lymphoblastic leukemia ALL-L1 Acute lymphocytic leukemia ALL-L2 Acute lymphocytic leukemia ALL- L3 Acute myeloid leukemia AML-M0 Acute myeloid leukemia AML-M1 Acute myeloid leukemia AML-M2 Acute myeloid leukemia AML-M2 + peroxidase Acute myeloid leukemia AML-M3 Acute myeloid leukemia AML-M3 hypogranular Acute myeloid leukemia AML-M4 Acute myeloid leukemia AML-M5 Acute myeloid leukemia AML-M6 Acute myeloid leukemia AML-M7/

Week 10: Leukemia AML ALL FAB classification WHO classification

without maturation M2 -- AML with maturation M3 -- Acute Promyelocytic Leukemia M4 -- Acute Meylomonocytic Leukemia M5 -- Acute Monocytic Leukemia M6 -- Erythroleukemia (DiGuglielmo’s) M7 -- Megakaryoblastic Leukemia M1 and M2 Myeloperoxidase (MPO) p-Phenylene diamine /polymerase in early lymphoblasts Cell surface markers (CD’s) Cytoplasmic and surface immunoglobulins: B-cell line T-cell receptor (TCR) WHO Classification of Lymphoproliferative Syndromes Precursor B Lymphoblastic Leukemia/Lymphoma (ALL/LBL/


staining may be helpful, e.g. positive monoblasts, NRBC, megakaryoblasts … Acute Lymphoblastic Leukaemia Laboratory Diagnosis FAB Classification Acute Lymphoblastic Leukaemia Laboratory Diagnosis Acute Lymphoblastic Leukaemia Laboratory Diagnosis Morphology Blast morphology is variable some are small with high/exposure; more frequent in M1, M2 subtypes +817 inv (3)rare Megakryocytic leukemia T 4;11rare Younger patients; lymphoid-monocytoid features; leukocytosis; poor prognosis inv (16) 6 M4 /

ACUTE LYMPHOBLASTIC LEUKEMIA Majid.vafaie The leukemias are the most common malignant neoplasms in childhood about 31 % of all malignancies that occur.

2-3% JMML for 1-2% Remaining cases consist of a variety of acute and chronic leukemias that do not fit classic definitions for ALL, AML, CML, or JMML Acute Lymphoblastic Leukemia Childhood ALL was the first disseminated cancer shown to be curable consequently has / with T-cell ALL T-cell ALL also has a higher leukocyte count Precursor B-cell ALL (CD10+ or common acute lymphoblastic leukemia antigen [CALLA] positive) is the most common immunophenotype with onset at 1-10 yr of age The median leukocyte count/

Pediatric Leukemias Resident Education Lecture Series.

blood of a patient with pancytopenia does not rule out the diagnosis of leukemia Recognize bone pain as a symptom of leukemia Recognize bone pain as a symptom of leukemia Understand that most patients with acute lymphoblastic leukemia will be cured of their disease using current treatment strategies Understand that most patients with acute lymphoblastic leukemia will be cured of their disease using current treatment strategies Identify the central/

Leukemia Rita All Carrie Warner.

to infection (Domino, 2014). Differential Diagnosis Chronic Myelogenous Leukemia Chronic Myelomonocytic leukemia Chronic neutrophilic leukemia Chronic eosinophilic leukemia Juvenile myelomonocytic leukemia Infectious mononucleosis Leukemoid reaction Polycythemia vera Treatment with granulocyte stimulating factors Acute myelogenous leukemia Acute lymphoblastic leukemia Atypical CML (Domino, 2014). Chronic Lymphocytic Leukemia Bacterial Tuberculosis Infectious mononucleosis Non hodgkins Lymphoma Hairy cell/

Acute lymphoblastic leukemia in adults

Specific chemotherapy Specific chemotherapy + Rituximab N=31 N=59 A Oriol et al, 2002 T-cell acute lymphoblastic leukemia Nelarabine Forodesine Alemtuzumab NOTCH-1 secretase inhibitors Imatinib T-ALL. Nucleoside analogs Fludarabine Cytarabine Nelarabine Cladribine Clofarabine/ therapy New cytotoxic drugs Thyrosine Kinase inhibitors MoAb Other Standard High Very-high History of Treatment in Acute Lymphoblastic Leukemia Cure Rate (%) Subtype / MRD Adjusted Tx 90 >90%? Chemotherapy 80 Single Combined High Dose /

Acute Lymphoblastic Leukemia An Overview

1970-72 499 1968-70 402 2 4 6 8 10 Total Number of Patients Treated: 16,131 Years after Study Entry Legend: Survival of CCG Patients with Newly-Diagnosed Acute Lymphoblastic Leukemia, 1968-1997. Bleyer A, Hather N, Personal Communication Prognostic Factors in Childhood ALL Age WBC count at presentation Immunophenotype Recurrent chromosomal abnormalities Response to initial therapy These prognostic factors have/

Diagnosis and Management Of Acute Leukemia in Children and Adolescents Grand Rounds September 20, 2010 St. Elizabeth Hospital, Lafayette, Indiana Bassem.

of the leukemic clone with differentiation blocked at an early stage Classification of Leukemias AcuteChronic Myeloid origin Lymphoid origin Acute Myeloid Leukemia (AML) Acute Lymphoblastic Leukemia (ALL) Chronic Myeloid Leukemia (CML) Chronic Lymphocytic Leukemia (CLL) Acute Leukemia Accumulation of blasts in the marrow Epidemiology Childhood leukemia represents 12% of all leukemias; 60% of all acute lymphoblastic leukemias Leukemia is the most common cancer diagnosed in children at 4.3/100.000/

Acute Leukemias 4 th Year Medical Student KAU. Acute Leukemia Is a type of cancer characterized by the production of large numbers of immature, abnormal.

CFU-GM BFU-E/CFU-E eosinophil pre-T pre-B myeloid progenitor cell lymphoid progenitor cell lymphoblast T-cell B-cell & plasma cell MIXED PROGENITOR CELL CFU-Megmegakaryocyte pluripotent stem cell Classification of Acue leukemias Acute Myeloid origin Lymphoid origin Acute Myeloid Leukemia (AML) Acute Lymphoblastic Leukemia (ALL) Classification of acute leukemias ALL mainly children M > F curable in 70% of children curable in minority of adults AML mainly/

Abstract Identifying Factors that Cause Acute Leukemias Laurel Edington Manchester-Essex High School, Manchester-by-the-Sea, MA Teacher, Dr. Maria Burgess,

-the-Sea, MA Teacher, Dr. Maria Burgess, Manchester-Essex High School Mentor, Dr. Karen Balen, Mass General Hosp, Boston, MA Acute leukemia is a cancer of the blood and bone marrow that acts quickly. There are two types of acute leukemiaacute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL.) AML is a cancer that affects myeloid cells while ALL is a cancer that affects the lymphoid cells. In/

Hematologic Malignancies. Definition Leuko = white Emia = blood Acute Leukemia: is a stem cell malignant disorder characterized by abnormal proliferation.

FAB (Frech-American-British) 1- Acute lymphoblastic Leukemia (ALL) L1 in children L2 in adults L3 Burkitt-lymphoma-like 2- Acute myeloblastic Leukemia (AML) AML M0 – acute undifferentiated leukemia M1 - AML with minimal differentiation M2- AML with differentiation M3- Acute promyelocytic Leukemia M4 – Acute myelomonoblastic leuk M4E – with peripheral eosinophilia M5- Acute monoblastic leukemia M6- Acute erythroleukemia M7- Acute megakaryoblastic leukemia Clinical Manifestations Dx suspected in presence of/

Retroviral oncogenesis Two major mechanisms identified in animals… n Retroviral Transduction l mediated by the “acutely-transforming retroviruses” u Rous.

drives the G1/S transition by phosphorylating Rb 5’3’ CCND1 t(11;14) junction 14q3211q13 IgH T cell acute lymphoblastic leukemia (T-ALL) n clinically homogenous disease n cytogenetically heterogeneous (in contrast with BL or FL) l over 12/ B cell lymphomas) encodes an anti-apoptotic protein. l E2A-HLF, a fusion gene associated with pre-B cell acute lymphoblastic leukemia, encodes a transcription factor that suppresses apoptosis. Clinical impact of Ph 1 chromosome n diagnosis n prognosis n disease monitoring/

Approach to Heme Malignancies Lymphoma, Multiple Myeloma, Acute Leukemia and Myeloid Disorders Dr. Michelle Geddes University of Calgary and Tom Baker.

lymphocytic lymphoma Acute leukemia (B cell ALL, T cell ALL) Hodgkins Lymphoma –Classical HL –Nodular lymphocyte predominant HL NonHodgkins Lymphomas Indolent Follicular Gastric MALT Small lymphocytic lymphoma Waldenstroms Mantle cell lymphoma Very Aggressive Burkitt Lymphoblastic lymphoma Aggressive Diffuse large B cell lymphoma Peripheral T Cell lymphoma Double hit lymphoma Case 1 – possible lymphoma 23 year old woman with cervical lymph node present for/

Leukemia Cell Study Strode Note: Meaningless title.

Note: Too many words and no image. Question Does Mer play a role in the development of Acute Lymphoblastic Leukemia? Does Mer play a role in the development of Acute Lymphoblastic Leukemia? Strode Note: Avoid yes/no research questions. Hypothesis I hypothesize that Mer will be abnormally expressed in/ the T-cell and B-cell Acute Lymphoblastic Leukemia cell lines REH and Jurkat, and certain patient samples. Strode Note: What’s wrong with this/

Leukemia By Mary Chen and Genesis Pimentel

crowds out normal cells  Enters bloodstream  liver, spleen, lymph nodes  4 Major types:  Acute Myelogenous Leukemia (AML)  Acute Lymphoblastic Leukemia (ALL)  Chronic Myelogenous Leukemia (CML)  Chronic Lymphocytic Leukemia (CLL). http://upload.wikimedia.org/wikipedia/commons/6/6f/Leukemia_cells.png Abnormal leukemia cells Types of LeukemiaAcute or chronic = how fast the cancer progresses  Acute immediate effects  Chronic gradual and may not show symptoms for years  Myelogenous or Lymphocytic/

Treatment of Leukemias and Lymphomas December 2013.

and Lymphomas December 2013 Treatments THE LEUKEMIAS THE LYMPHOMAS THE LEUKEMIAS Acute LeukemiasAcute Lymphoblastic Leukemia (ALL) Childhood LeukemiaAcute Myelogenous Leukemia (AML) Adult Leukemia Chronic Leukemias  Chronic Myelogenous Leukemia (CML)  Chronic Lymphocytic Leukemia (CLL) THE LYMPHOMAS Hodgkins Disease Non-Hodgkins Lymphomas Acute Lymphoblastic Leukemia (ALL) Childhood Leukemia (1) ALL is the predominant form of leukemia in childhood, and it is the most common form of cancer in/

Lymphoma. Haematological Neoplasia - Overview Leukemias: Leukemias: Acute & Chronic, Acute & Chronic, Myeloid & Lymphoid Myeloid & Lymphoid Lymphomas:

Lymphoma Haematological Neoplasia - Overview Leukemias: Leukemias: Acute & Chronic, Acute & Chronic, Myeloid & Lymphoid Myeloid & Lymphoid Lymphomas: Lymphomas: Hodgkins & Non-Hodgkins Hodgkins / large cell Follicular large cell Diffuse small cleaved Diffuse small cleaved High-grade NHL: High-grade NHL: Immunoblastic Immunoblastic Lymphoblastic Lymphoblastic Miscellaneous: Histiocytic, Mycosis etc. Miscellaneous: Histiocytic, Mycosis etc. Non-Hodgkin lymphoma Incidence Diffuse large B-cell lymphoma /

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations Amani Mohemmidan Supervised.

transgenic mice developed AML; the other 45% of hMRP8-AML1-ETO transgenic mice and 100% of wild-type littermates developed acute lymphoblastic leukemia. Discussion con- This results provide direct evidence that AML1-ETO plays an important role in the in vivo development of myeloid leukemia. ENU is a strong carcinogenic mutagen. ENU transfers its ethyl group to oxygen or nitrogen radicals in DNA, resulting/

Professor Hala Al-Rimawi JUST & KAUH 2016.  Over view of childhood leukemia  Discussion of a case of acute lymphoblastic leukemia  The common signs.

Professor Hala Al-Rimawi JUST & KAUH 2016  Over view of childhood leukemia  Discussion of a case of acute lymphoblastic leukemia  The common signs and symptoms of ALL  The methods of diagnosis of ALL  Outline the treatment of ALL Over view  Acute leukemia is the most common form of childhood cancer, representing 32% of all cancers ALL is most commonly originate from early stage of B lymphocytes (pre/

Insert Program or Hospital Logo Introduction Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. It comprises 25% of childhood malignancy.

unintentionally missed doses. Hypothesis 6-Mercaptopurine can cause drug-induced pancreatitis in children undergoing chemotherapy for Acute Lymphoblastic Leukemia. Methods A retrospective chart review was performed on seventy-one active pediatric patients treated with COG/asparaginase. References 1. Hunger, Stephen P., et al. "Improved Survival for Children and Adolescents with Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report from the Childrens Oncology Group." Journal of Clinical Oncology 30.14/

Adult ALL – therapeutic strategies, including Burkitt

related diseases e.g. Elderly, Adolescents, T-LBL Methods and Definition of Minimal Residual Disease (MRD) in Acute Lymphoblastic Leukemia = leukemic blast cells undetectable by microscopic examination of bone marrow (<1-5% blast cells) Definition of Mol./ and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL positive acute lymphoblastic leukemia. Blood. 2004;104:3507-3512. Event-free and Overall Survival of PH+ ALL Comparison of ALL202 (+IM)/


and AML Myeloblast type II Myeloblast type I Types of blast cells in ALL and AML Special staining methods in acute leukemias FAB-classification of ALL L1-lymphoblasts in the BM ALL-L1 L2-lymphobalsts in the BM ALL-L2 ALL-L3 L3-lymphoblasts in the BM SBB (SHOULD BE –ve) MPO (SHOULD BE –ve) FAB-classification of AML M0 Undifferentiated blast cells (Myeloid/

Chapter 25: Acute Lymphoblastic Leukemia. Causes a wide spectrum of syndromes – From involvement of bone marrow and peripheral blood(leukemias) to those.

Chapter 25: Acute Lymphoblastic Leukemia Causes a wide spectrum of syndromes – From involvement of bone marrow and peripheral blood(leukemias) to those that cause masses (lymphomas) in lymphoid organs. The cell of origin may involve the common lymphoid progenitor cell OR differentiated progenitors of the T, B or NK cells – /

E2A and Acute Lymphoblastic Leukemia (ALL) Jeremy Petree.

" Null mutant mice develop thyomas within 75 days after birth Heterozygosity in Mice Lack of functional E2A to act as a tumor suppressor Increase the population of undifferentiated progenitor cells Acute Lymphoblastic Leukemia (ALL) 3,930 new cases each year Usually affects children under 19 Frequency increases in older individuals Malignant immature white blood cells Blocks the production of normal bone marrow cells/

Treatment of Acute Leukemia in Children Hyo Seop Ahn, MD Professor Emeritus, Seoul National University College of Medicine Department of Pediatrics Bundang.

;Yes) Complications -Late effects Cardiomyopathy Osteonecrosis Endocrine–growth delay, hypothyroidism, gonadal dysfunction Renal–reduced GFR Psychological–intellectual dysfunction Second malignancy Cataract Multicenter study to establish proper treatment of high risk acute lymphoblastic leukemia in children in Korea 12 Institutions in 2005 26 Institutions in 2013 Supported by Ministry of Public Health and Welfare Current Problem and Development of Treatment in Childhood ALL Standard/

Leukemia. About the Disease Leukemia, lymphoma and myeloma are cancers that originate in the bone marrow (leukemia & myeloma) or in lymphatic tissues.

the myeloid cells are affected it is called Myelongenous Leukemia Types of Leukemia Acute lymphoblastic Leukemia (ALL) Acute myeloblastic Leukemia (AML) Chronic lymphocyte Leukemia (CLL) Chronic myeloid Leukemia (CML) Demographics of Leukemia Patients (2001 Data) Total Reported Cases = 31,500 Sources from Leukemia, Lyphoma, Myeloma Facts 2001 CLL=Chronic Lymphocytic ALL=Acute Lymphocytic CML=Chronic Mylogenous AML=Acute Mylogenous Chronic and Acute Chronic Leukemia: Progress slowly (runs a slow course) Not/

Lymphoma and Myeloma | Kristine Krafts, M.D.. Leukemia Malignancy of hematopoietic cells Starts in bone marrow, can spread to blood, nodes Myeloid or.

or non-Hodgkin Hematologic Malignancies Leukemias Acute leukemias Chronic leukemias Lymphomas Hodgkin lymphoma Non-Hodgkin lymphoma Plasma cell disorders Multiple myeloma Hematologic Malignancies Leukemias Acute leukemias Chronic leukemias Lymphomas Hodgkin lymphoma Non-Hodgkin lymphoma/Small lymphocytic lymphoma Malt lymphoma Follicular lymphoma Mycosis fungoides Low-gradeHigh-grade Large cell lymphoma Lymphoblastic lymphoma Burkitt lymphoma Types of NHL Small mature lymphocytes Same thing as CLL CD5+ Long/

Hematology There are four lectures: 1.Acute leukemias (2 hours). 2.Chronic leukemias (2 hours).

فرع الامراض والطب العدلي M. B. Ch. B. & F. I. C. P.(Hematopathology) الثلاثاء 2015/3/30 الساعة الحادية عشرة والنصف صباحا Definition and classification of acute leukemias Definition: Acute leukemias are blast cell malignancies or malignancies of immature hemopoietic cells. Classification: 1.Acute myeloid (myeloblastic) leukemia (AML) 2.Acute lymphoid (lymphoblastic) leukemia (ALL). 3.Mixed AML+ALL. Aetiology of acute leukemias 1.Ionizing radiation(x-rays, atomic bombs &radiotherapy for lymphoma may cause/

Introduction to Leukemia

myeloproliferative disorders. The non-leukaemic lymphoproliferative disorders. The Acute Leukemias Acute leukaemias are characterized by uncontrolled proliferation of poorly differentiated cells (blasts). The acute leukemias are divided on the basis of the predominant haemopoietic lineage involved into:   Acute lymphoblastic leukaemia (ALL). Acute non-lymphoblastic leukaemia (ANLL). Main Classification FAB classification Acute non-Myeloid leukemia Acute Myeloid leukemia ALL L1 L2 L3 AML M0 M1 M2 M3/

Lecture 6 and 7 Myelodysplastic syndromes; Chronic lymphocytic leukemia and related lymphoproliferative disorders Abdulkarim Aldosari.

of research Characterized mainly by chromosomal deletions Either sections of a chromosome or the entire chromosome Versus chromosomal translocations in acute leukemias Deletions follow a tumor suppressor gene model Tumor-suppressor genes generally encode proteins that inhibit cell proliferation – (in MDS/ questions A cell that could suggest that lymphocytes in CLL are not normal is a: A) Smudge cell B) Lymphoblast C) Monoblast D) All of the above E) None of the above Ans. A Review questions Which type of/

Acute Leukemia and the FLT3 Receptor By: Betty Sa’ Mentor: Dr. Govind Bhagat Site: Columbia University Vanderbilt Clinic.

cancer of the blood in which immature hematopoietic cells proliferate in an uncontrolled manner. Leukemia originates in the bone marrow and quickly spreads elsewhere. There are four major types of Leukemia, Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Chronic Myeloid Leukemia, and Chronic Lymphocytic Leukemia. But we are only focusing on AML and ALL. Acute: means that the disease appears quickly and advances rapidly, so patients with ALL and/

Osce Hematology DR.HASSANALI VAHEDIAN ARDAKANI. Leukemia cells feather edge.

Acute myelomonocytic leukemia (M4) Beta thalassemia intermedia Beta thalassemia trait Hgb H inclusions golf ball-like Hemoglobin H disease Megakaryocytes Petechiae in ITP Petechiae in Henoch-Sch?nlein purpura Giant platelets Bone marrow in aplastic anemia Myelodysplastic syndrome with abnormal megakaryocytic maturation Acute lymphoblastic leukemia Gaucher cells Niemann Pick Cells Megaloblastic erythropoiesis Lymphoblasts (FAB L2) Acute lymphoblastic leukemia (FAB L3) Acute promyelocytic leukemia (M3) Acute/

Leukemia By: Gabie Gomez. What is Leukemia? Blood consists of plasma and three types of cells, each type has a special function. RBC, WBC and Platelets.

high-risk cases Blood transfusions may be given is anemia is severe. Medications used are Leukeran, and Cytoxan. Survival Rates About 98 to 99 percent of children with newly diagnosed acute lymphoblastic leukemia attain initial complete remissions (absence of detectable leukemic cells by microscopic examination) in four to six weeks. About 80 percent of children can be cured. Patients who remain/

Relapse in Children with ALL By Dr Kaji Protocol for Acute Lymphoblastic Leukemia Relapse IN LANZKOWSKY.

survival was interval between first CR and occurrence of the first relapse. Pediatr Blood Cancer. 2011;57:210–216. 2011 Wiley-Liss, Inc.  Outcome of Childhood Acute Lymphoblastic Leukemia With Induction Failure Treated by the Japan Association of Childhood Leukemia Study (JACLS) ALL F-Protocol The aim of this prospective study was to evaluate the efficacy and safety of the Japan Association of Childhood/

E2A and acute lymphoblastic leukemias (ALL). A closer look at the E2A gene... Other names: TCF3, ITF1, and Factors E12/E47 Located on chromosome 19 Encodes.

regulation of cell proliferation Wnt16: encodes a member of the WNT/WG family of growth factors; members of this family have been identified as potent activators of growth and differentiation Acute Lymphoblastic Leukemia (ALL) Most common form of childhood cancer Undifferentiated lymphoid cells accumulate in bone marrow, replace normal blood cells, and spread to other parts of the body ~3,000 children are/

Challenges and Considerations in Linking Adult and Pediatric Leukemias David G. Poplack M.D. Texas Children’s Cancer Center Baylor College of Medicine.

%20% Chronic Myeloid15%<5% Chronic Lymphocytic26%N/A Adults have a worse prognosis! Survival in Acute Leukemias Survival in Acute Leukemias AdultsChildren Acute Lymphoid50-60%80-85% Acute Myeloid10-20%40-50% ACUTE LEUKEMIAS A heterogeneous group of disorders! Survival of Children with Acute Lymphoblastic Leukemia 80 60 40 20100 Years of Number of 1972-75 1972-75 02 4 8610 Years from Diagnosis % %SurvSurvIIVaVall%SurvSurvIIVaVallIl 1989-93 1983-89 1978/

The acute Leukemias are clonal hematopoietic malignant disease that arise from the malignant T r a n s f o r m a t i o n of an early Hematopoietic stem.

Blood Lymph nodes spleen Liver Skin Meningeal Other Organs FAB Classification of acute Leukemia Acute Myeloblastic Leukemia M1- Acute Myeloblastic L. without differentiation M2- A.M.L.with diferentiation (predominantly Myloblast & promyeloblast M3- Acute promyeloblatic leukemia M4- Acute Myelomonocytic leukemia M5- Acute Monocytic Leukemia M6- Erythroleukemia M7- Megakariocytic Leukemia Acute Lymphoblastic Leukemia L1- Small cells,Homogeneous population,childhood variant. L2- Larger L. Heterogeneous/

Leukaemias. Leukaemias: Malignant Disease of WBC Forming tissue or other hemopoietic elements: Lymphoblastic (ALL) Lymphoblastic (ALL)Acute Myeloid (AML)

regulated by different lineage -specific transcription factors, accordingly, the mutated transcription factor genes found in acute leukemias. Clinical features - Abrupt, onsent -Clinical signs and symptoms related to suppressed marrow function, including/ Total WBC count Normal, low, or increased Leukaemia: Neoplastic disease of WBC forming tissue. Classification (FAB) I. Acute lymphoblastic leuk. ALL Morphological Morphological L1 – Monomorphic type.... Good risk L2 – Heterogenous type L 3 – Burkitt ’ s/

Adult acute lymphocytic leukemia Adult acute lymphocytic leukemia Jaya V.Juturi MD 5/5/2004.

-15% FAB classification Cellular classification (FAB) L-1 mature appearing lymphoblasts L-2 pleomorphic lymphoblasts L-3 is most B-cell ALL 95% of all acute lymphocytic leukemias except B-cell type have and elevated TdT expression (terminal deoxynucleotidyl transferase/ MTX, vincristine, and prednisone (POMP). Results of Treatment With Hyper-CVAD, a Dose-Intensive Regimen, in Adult Acute Lymphocytic Leukemia … Journal of Clinical Oncology, Vol 18, Issue 3, 2000: 547 91%achieved complete remission (CR) and 6/

Mary E. MacBlane MS, PNP-BC

Viral Titers Chest x-ray CBC w/ Differential WBC’s Hgb ↓ Platelet Ct ↓ Diff ↑ or ↓ Neutropenia Peripheral Blasts Types of Childhood Leukemia ALL – Acute Lymphoblastic Leukemia AML – Acute Myeloid Leukemia CML – Chronic Myeloid Leukemia Classification by Cell Lineage Acute Lymphocytic Leukemia (ALL) Most common cause of childhood leukemia Peak age: 2-5 years Males > females ALL – Best Prognosis Ages 1-9 Females Initial WBC < 10,000 Favorable cytogenetics Early response/

Leukemia! What is your role? Presented by Jaisson Mailloux.

blood cells fight diseases Platelets are for blood clotting Introduction to Leukemia Types of Leukemia They are subdivided further into four groups: 1.Acute Lymphoblastic Leukemia (ALL) 2.Acute Myelogenous Leukemia (AML) 3.Chronic Lymphocytic Leukemia (CLL) 4.Chronic Myelogenous Leukemia (CML) Introduction to Leukemia Types of Leukemia The type of Leukemia is determined by what happens in the bone marrow. 1.Acute, accumulation of immature, useless cells 2.Chronic, allows more mature/

Acute Lymphoblastic Leukemia. Causes a wide spectrum of syndromes – From involvement of bone marrow and peripheral blood(leukemias) to those that cause.

Acute Lymphoblastic Leukemia Causes a wide spectrum of syndromes – From involvement of bone marrow and peripheral blood(leukemias) to those that cause masses (lymphomas) in lymphoid organs. Arise / – Onset symptoms rapid, fatigue, infections, bruising – Prognosis not good Symptoms are related to the replacement of normal marrow elements with leukemic lymphoblasts – Anemia, thrombocytopenia, neutropenia – Fever, weight loss, pallor, fatigue – Petechiae and eechymoses present in half of the patients – Bone /

Ads by Google