Ppt on abo blood grouping experiment

1 European Blood Alliance: Corporate presentation July 2013 1.

partners Regular mail exchanges, Q/A through EBA office Information/experience sharing: active in each WG Member consultations: followed by /blood and plasma donations and donors. Blood Transfus 2013. Participation in the stakeholder engagement sub-group of the ABO Risk Based Decision Making WG 26 27 Developing international Collaboration Council of Europe – Blood supply management (TS003); EU report on blood landscape ; VNRD; Plasma supply management Alliance of Blood Operators (ABO) and America’s Blood/


POSTPARTUM CARE.

"The lungs of the fetus carry out respiratory gas exchange in utero similar to what an adult experiences." C) "The placenta assumes the function of the fetal lungs by supplying oxygen and allowing the/ ABO incompatibility Ineffective breastfeeding & dehydration Certain medications (aspirin, tranquilizers, and sulfonamides) Maternal enzymes in breast milk- fairly uncommon Hypoglycemia Hypothermia Decreased liver function Anoxia Lab Testing Elevated serum bilirubin (direct and indirect) Blood group /


The stubborn platelet - rEFRACTORINESS AT ITS WORST

response HPA Express a variety of antigenic markers on their surface,Some are shared : Blood group ABH , HLA,Some are specific : Platelet specific antigens Alloantibodies to mismatched HLA can /19%-7%, Europe ,US) Pavenski et al, Tissue antigens 2012 Management ABO matched platelet (<48 hrs old) HLA matching Challenge in obtaining a well / etal 2012 A prospective quality evaluation of single donor platelets (SDP) - an experience of a tertiary healthcare center in India., Chodhry VP Platlet therapy ,IJP 2002 /


Tuesday 3/18/14 AIM: how is human blood typed? DO NOW: What is the function of leukocytes and how are they useful to crime scene investigation? HOMEWORK:

-abo.html Blood group A If you belong to the blood group A, you have A antigens on the surface of your RBCs and B antibodies in your blood plasma. Blood group B If you belong to the blood group B, you have B antigens on the surface of your RBCs and A antibodies in your blood plasma. AB0 blood grouping system Blood Groups, Blood Typing and Blood Transfusions The discovery of blood groups Experiments with blood transfusions, the transfer of blood/


Objective 5: TSWBAT use the ABO blood system as both an example of multiple allelic and codominant inheritances. Objective 6: TSWBAT recognize examples.

. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings Most genes have more than two alleles in a population. The ABO blood groups in humans are determined by three alleles, I A, I B, and I. Both the I A and I B alleles/ (BbCc) will follow the law of independent assortment. However, unlike the 9:3:3:1 offspring ratio of an normal Mendelian experiment, the ratio is nine black, three brown, and four white. Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings Fig/


Adverse Effects of Blood Transfusion. Adverse Effects of Blood Transfusion ANY unfavorable consequence is considered an adverse effect of blood transfusion.

for hemolysis in pre-transfusion specimen: – detectable at 20mg/dL Post transfusion bilirubin monitoring Visual inspection of Blood bag and lines Post Transfusion Lab Testing Direct Antiglobulin Test (DAT) Recipient post-tx’n spec. (DO THIS FIRST) Positive? Perform eluate and identify antibody ABO Grouping and Rh Typing Recipient pretransfusion and posttransfusion specimen Donor segment and bag. Post Transfusion Lab Testing Crossmatch Recipient/


Serology. Blood is the bodily substance most commonly found at the scene of a crime or on a person, clothing, or a weapon potentially associated with.

traces of blood, especially older dried blood stains. Even smear marks caused by wiping or mopping in attempts to remove blood stains can be “visualized” by using luminol. Caution: experience needed; glowing is not always blood; actual bloodstains/a criminal investigation. Serology Conventional Analysis We use blood-grouping systems with suspected parents & offspring using the human leukocyte antigen (HLA) test rather than ABO system. Leukocyte = white blood cell. Currently, DNA testing can increase the /


Transportation. Blood Some biologists have long referred to human blood as "the sea within us." Our blood makes available to all of our body cells.

blood isnt doing its job properly. Blood Groups The most well-known and medically important blood types are in the ABO group. They were discovered Karl Landsteiner in the process of trying to learn why blood transfusions sometimes cause death and at other times save a patient. Landsteiners rules for the ABO Blood Group/, however they may occur at any age. Before an aneurysm ruptures, the individual may experience such symptoms as a sudden and usually severe headache, nausea, vision impairment, vomiting, and/


TRANSPORT IN PLANTS AND ANIMALS BLOOD GROUPS AND BLOOD TRANSFUSION Lesson objectives; By the end of the lesson the learner should be able to explain the.

able to explain the reaction between antigen and antibobody Blood groups Types of blood group systems include; ABO system (e.g. blood type A, B, AB & O), Rhesus factor (e.g. rhesus positive & rhesus negative), Types of blood group systems include; ABO system (e.g. blood type A, B, AB & O), Rhesus factor (e.g. rhesus positive & rhesus negative), ABO BLOOD GROUP Blood groups EXPERIMENT experiment Blood transfusion During blood transfusion the donor’s antigen A & B on RBC/


Figure 14.1. Mendel’s Experiment Advantages of pea plants for genetic study –There are many varieties with distinct heritable features, or characters.

Inc. Figure 14.11 Carbohydrate Allele (a) The three alleles for the ABO blood groups and their carbohydrates (b) Blood group genotypes and phenotypes Genotype Red blood cell appearance Phenotype (blood group) A A B B AB none O IAIA IBIB i ii IAIBIAIB /are not good subjects for genetic research –Generation time is too long –Parents produce relatively few offspring –Breeding experiments are unacceptable However, basic Mendelian genetics endures as the foundation of human genetics © 2011 Pearson Education, Inc./


Blood SBI 3U Ms. Raper. Function of Blood Transport oxygen - oxyhemoglobin Transport nutrients: - glucose, amino acids, Transport wastes – CO 2, urea,

-A AB A and BNone OOONoneAnti-A and Anti-B http://ntri.tamuk.edu/immunology/blood.html http://www.sirinet.net/~jgjohnso/bloodtype.jpg Fig 2. ABO Tile Grouping anti-Aanti-Banti-A+B group A group B group AB group O http://www.umds.ac.uk/tissue/bludgrp2.html#Abbs The various ABO blood groups occur in the average population of the US in the proportions shown here. 45/


Blood Groups Clotting Time and Bleeding Time. Aims of the Practical To determine: 1.Blood groups. 2.Clotting time. 3.Bleeding time.

Blood Groups Blood Groups Blood Groups ABO System: ABO System: – Group A: – Group A: antigen A on RBC membrane anti B in plasma. – Group B: – Group B: Antigen B on RBC membrane Anti A in plasma. – Group AB: – Group AB: Antigen A and B on RBC membrane NO antibodies in plasma. – Group O: – Group/should not be touched once the puncture has been made until the experiment is over. Procedure cont…. Apply a piece of filter paper to the blood-drop every 30 seconds until the bleeding stops. The bleeding time /


EXPERIENCE OF THE NBTC IN THE PREPARATION OF AHSC GRAFT IN TUNISIA PREPARED BY: NADRA GABSI LEILA BEN HAMED F. JENHANI T. BEN OTHMEN S. HMIDA E. GOUIDER.

EXPERIENCE/BLOOD METHODS Major Minor Mixed ReceiverDonor GRAFT PREPARATION ABO- incompatibility Blood cell depletion (Major or mixed ABO-incompatibility) Ficoll density gradient centrifugation Manual blood cell depletion (Major and mixed ABO-incompatibility) Ficoll density gradient centrifugation Manual blood cell depletion (Major and mixed ABO/ coefficient=0.406 MinorCompatible Major & mixed 474 CASES TOTAL 3 groups No immediate or delayed hemolysis No infectious events related to graft contamination/


Patterns of Inheritance

Patterns of Inheritance Chapter 23 Gregor Mendel 1822 – 1884 Austrian monk Experimented with garden peas Provided a basis for understanding heredity Mendel cont’d Published a paper in 1866 stating that parents pass / I, IA and IB are codominant Phenotype Genotype A IAIA or IAi B IBIB or Ibi AB IAIB O ii Codominance cont’d. Paternity testing- ABO blood groups often used Can disprove paternity but not prove it Rh factor- another antigen on RBCs Rh positive people have the antigen Rh negative people lack it /


In a typical experiment, Mendel mated two contrasting, true-breeding varieties, a process called hybridization The true-breeding parents are the P generation.

in more than two allelic forms For example, the four phenotypes of the ABO blood group in humans are determined by three alleles for the enzyme (I) that attaches A or B carbohydrates to red blood cells: IA, IB, and i. The enzyme encoded by the IA /pea plants are controlled by single genes. Answer: D 61 Pea plants were particularly well suited for use in Mendel’s breeding experiments for all of the following reasons except that peas show easily observed variations in a number of characters, such as pea shape/


Blood Groups Clotting Time and Bleeding Time

and clotting time in haemostasis. Blood Groups ABO Blood Groups ABO System: Group A: antigen A on RBC membrane antiB in plasma. Group B: Antigen B on RBC membrane AntiA in plasma. Group AB: Antigen A and B on RBC membrane NO antibodies in plasma. Group O: NO antigen on RBC/of the ear should not be touched once the puncture has been made until the experiment is over. Procedure cont…. Apply a piece of filter paper to the blood-drop every 30 seconds until the bleeding stops. The bleeding time estimated by this /


ABO Blood Groups Rhesus Factor +-. Why are blood types important?  Blood transfusion  A blood transfusion creating a wrong combination of donor-patient.

ABO Blood Groups Rhesus Factor +- Why are blood types important?  Blood transfusion  A blood transfusion creating a wrong combination of donor-patient blood types could result in the death of the patient.  Furthermore a wrong combination donor- patient of the Rhesus factor could also provoke a rejection from the patient’s body and result in death. Blood Types History  Karl Landsteiner (1900) found out that the blood of two people/


Chapter22 Population Genetics Individuals can carry only two different alleles of a given gene. A group of individuals can carry a large number of different.

workers tested the models using biochemical and molecular techniques that measure variation directly at the protein and DNA levels. These experiments examined allele frequencies and the forces that alter the frequencies, such as selection, mutation, migration, and random genetic /.4 Extensions of the Hardy-Weinberg Law We commonly find several alleles of a single locus in a population. The ABO blood group in humans (discussed in Chapter 4) is such an example. The locus I (isoagglutinin) has three alleles (I/


1 Hot Topics New Blood and Plasma Issues Barbara Carmichael Investigator, U.S. Food & Drug Administration Florida District - Jacksonville, FL Resident.

immediate spin compatibility test –The card is not a reliable detector of ABO incompatibilities (which are predominantly IgM); published studies document reported compatibility test/] [compatibility testing] [storage] [distribution] of blood or blood components are not adequate in [number] [educational background] [training and experience, including professional training as necessary] to assure competent/ one of same or greater sensitivity (e.g. HIV-1 Group O)Retests - should use the same test as that used for /


Ron Travaglino Director. Accommodating Patients’ Requests For Medical Treatment Without Allogeneic Blood.

experience Growing patient population supplies data for more education Supports patient’s rights and autonomy Good economics Who are the Patients? Religious Motivation –Primarily* Jehovah’s Witnesses Non - Religious Motivation –Concern over blood/of Blood Transfusions Incompatibility (ABO and other groups) (ABO and other groups) Infectious complications Infectious complications Immunomodulatory Immunomodulatory Resource availability Resource availability Risk to Benefit Ratio Risk to Benefit Ratio Blood /


Hemolytic anemia HA is a complex and serologically challenging subject, requiring specialized knowledge and lab experience. HA is a complex and serologically.

The sensitizing antibody is usually IgG with Rh specificity. Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficency may experience a hemolytic episode if given drugs containing aspirin. Anti-malaria drugs are also a potential cause of acute /progenitor cell or organ transplantation. Passenger lymphocytes of donor origin produce antibodies directed against ABO or other blood group antigens on the recipient ’ s cells, causing a positive DAT. 4. Administration of IVIG or IV anti/


Blood System. The heart pumps about 1 million barrels of blood in a lifetime.

and Rh factor if a patient is going to receive blood The ABO System What is the ABO system? The ABO system consists of people with blood groups A, B, AB or O. A mix-up in the blood types during transfusion could be fatal to the receiver as the blood would agglutinate within him forming numerous blood clots eventually leading to death. What is the Rhesus Factor? Irregardless/


The Impact of Systems Improvements: A Progress Review of Healthcare-Associated Infections & Blood Disorders and Blood Safety August 28, 2013.

,000-1.2 million Americans experience VTE and 350,000 to 600,000 Americans experience DVT/PE each year1,2,/ABO incompatibility and post-transfusion virus transmission SOURCE: National Blood Collection and Utilization Survey (NBCUS), HHS/OASH. Presentation Outline Healthcare-associated infections Blood Disorder and Blood Safety Blood/ initiatives: Developing and expanding outreach strategies and patient support groups Establishing statewide newborn screening for thalassemia Supporting successful transition to/


Surviving Change in the 21st Century

maniacal behavior Transfused blood of a calf two times The Fate of Mr. du Mauroy Two months later he began to experience maniacal behavior Wife sought/ Abandoned when saline became available Adler J. 1892 Era of Modern Blood Banking 1900 Karl Landsteiner discovered ABO System 1913 Reuben Ottenberg Describes compatibility testing O as “universal” /to 25.1) and control (19.9, 13.6 to 26.2) groups. Results Overall effect of treatment was not significant (P=0.689) and the/


Army Combat Developments and the Laboratory SAFMLS 2010

expertise through the experimentation process in all applicable Joint and Army experiments and warfighting exercises. 2. Organizational and Personnel Systems Division / or its photoproducts before transfusion ABO/Rh Card Features Credit card /Blood Support Detachment STRATEGIC TACTICAL ROLE III Blood Products: All Blood Products RBCs Group O, A, B FFP Group AB, A, B, O Platelets in theater (Pedigree donor) FWB ROLE II Blood Products: Limited Blood Products Group O RBC AB Plasma FWB (Untested) ROLE I Blood/


Unit 3: Genetics. 1. Explain the significance of Mendel`s experiments and observations and the laws derived from them. a. Explain the concept of independent.

vs. green, wrinkled vs. smooth). Easy to cross pollinate for humans. Kept careful records. Mendel and His Experiments Gregor Mendel: Austrian monk 1822-1884 studied garden peas Mendel studied peas and cross-fertilized them by hand. Peas /IAiType A Blood IBIB or IBiType B Blood IAI BType AB Blood * iiType O Blood * This is codominance - different alleles expressing their full phenotype in a heterozygote, giving a new phenotype. Exceptions to Mendels Laws Example Questions... 1. For ABO blood groups, the/


The Bloody Facts A Presentation All About Blood. Brief Composition of Blood What is blood made up of? What is blood made up of? Adult human has about.

on Chromosome 9 ABO blood groups AB0 blood grouping system According to the AB0 blood typing system there are four different kinds of blood types: A, B, AB or 0 (null). According to the AB0 blood typing system there are four different kinds of blood types: A, B, AB or 0 (null). Blood group A A antigens and anti-B antibodies Blood group B B antigens and anti-A antibodies Blood group AB Both A/


Blood Blood groups Rh factor Blood Tranfussion. What is blood made up of? An adult human has about 4–6 liters of blood circulating in the body. Blood.

O (null). ABO blood grouping system Blood group A If you belong to the blood group A, you have A antigens on the surface of your RBCs and B antibodies in your blood plasma. Blood group B If you belong to the blood group B, you have B antigens on the surface of your RBCs and A antibodies in your blood plasma. AB0 blood grouping system Blood Groups, Blood Typing and Blood Transfusions The discovery of blood groups Experiments with blood transfusions, the/


Gregor Mendel “Father of Genetics” His work wasn’t discovered

? Answer: Bushy (Bb) 50% and fine (bb) 50% Monohybrid Cross A breeding experiment that tracks the inheritance of a single trait. Dihybrid Cross A breeding experiment that tracks the inheritance of two traits. Mendel’s “principle of segregation” a. pairs/Example: ABO blood group system has three alleles of the gene: IA, IB, and IO. See Chapter 31 ABO Blood Reactions Are Important in Transfusions 75 O is the universal donor (can donate blood to anyone) AB is the universal recipient ( can receive blood from /


How can blood type be used to exclude paternity?

ABO blood types to determine if Mr. Johnson can be excluded as the father of any of Mrs. Johnson’s children. Background Information Modeling Agglutination Anti-A serum contains Anti-A antibodies A antigen and Anti-A antibodies bind, causing agglutination A blood has A antigen Get Your Experiment ON! Materials Design an Experiment Blood/investigations? How could we improve our experimental designs? Revisions (10 minutes) Your group has ten minutes to collect additional data and make revisions to your claim, /


Understanding Blood & Blood Type

Rh antibodies. A person with Rh+ blood can receive blood from a person with Rh- blood without any problems.                How is blood type genetically determined? Blood type is determined by the ABO & Rh genes. The ABO genes are determined by multiple and co-/ it? At the hospital, 2 newborn babies were accidentally mixed up and the parents questioned which baby belonged to whom. The blood groups of everyone involved is listed below. Determine which baby belongs to which couple. Baby 1 – Type A Mr. Brown –/


Fig. 14-1. Answer the following with your partner 1. What does a “pure strain” or true-breeder” mean? Think about Mendel’s pea experiments. 2. What is.

They have only four pairs of chromosomes Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings Fig. 14-8a EXPERIMENT P Generation F 1 Generation Predictions Gametes Hypothesis of dependent assortment YYRR yyrr YR yr YyRr  Hypothesis of independent assortment or/. 14-11 IAIA IBIB i A B none (a) The three alleles for the ABO blood groups and their associated carbohydrates Allele Carbohydrate Genotype Red blood cell appearance Phenotype (blood group) I A I A or I A i A B I B I B or I/


Mendel & Genes Chapter 14. Mendel’s contributions Used scientific methodology when conducting experiments. Used a quantitative approach Discovered fundamental.

Range from complete dominance to codominant One allele does not subdue the other; they reflect the pathways of expression Multiple alleles The ABO blood groups in humans are determined by three alleles, I A, I B, and i. Both the I A and I B alleles/ (BbCc) will follow the law of independent assortment. However, unlike the 9:3:3:1 offspring ratio of an normal Mendelian experiment, the ratio is nine black, three brown, and four white. Polygenic inheritance the additive effects of two or more genes on /


Gregor Mendel documented a particulate mechanism of Inheritance through his experiments with garden peas Copyright © 2008 Pearson Education Inc., publishing.

14-11 IAIA IBIB i A B none (a) The three alleles for the ABO blood groups and their associated carbohydrates Allele Carbohydrate Genotype Red blood cell appearance Phenotype (blood group) I A I A or I A i A B I B I B or/ Humans are not good subjects for genetic research –Generation time is too long –Parents produce relatively few offspring –Breeding experiments are unacceptable However, basic Mendelian genetics endures as the foundation of human genetics Copyright © 2008 Pearson Education Inc., publishing/


The life and work of Gregor Mendel Over seven years, Mendel experimented on more than 28,000 pea plants! Why were his experiments so successful? Pea.

phenotypes. SS ww Sw smooth wrinkly smooth Genotype heterozygous homozygous dominant homozygous recessive Phenotype Mendel carried out experiments investigating just a single characteristic, which is called a monohybrid cross. The likelihood of a trait being/ antigens –B Type = B Antigens –O Types = No antigens Blood Types Which type can receive blood from all others? Which can give blood to all others? Punnett Squares & Blood Types Inheritance of the ABO Blood Groups  A, B, and O alleles  The A and B /


Extensions to Mendelism

Extensions to Mendelism Mendels pea experiments used a very simple genetic system: each gene had 2 alleles, one dominant and one recessive, and genes did not interact with each other/they are monomorphic. Having 2 alleles, as in Mendels’ genes, is called dimorphic. Genes with multiple alleles can have a variety of dominance patterns between the alleles. ABO Blood Group The ABO blood group is a common multiple allele system. The gene itself is called I, and it has 3 alleles: IA, IB, and iO. IA and IB are co-/


Extensions to Mendel’s Genetic Model

Extensions to Mendel’s Genetic Model Mendels pea experiments used a very simple genetic system: each gene had 2 alleles, one dominant and one recessive, and genes did not interact with each/are monomorphic. Having 2 alleles, as in Mendel’s genes, is called dimorphic. Genes with multiple alleles can have a variety of dominance patterns between the alleles. ABO Blood Group The ABO blood group is a common multiple allele system. The gene itself is called I, and it has 3 alleles: IA, IB, and iO. IA and IB are co/


With your group on a piece of paper answer the following questions What do you think of when you hear the word “genetics”? What are 3 examples of a trait?

crossed a red flower and a white flower… what color would the offspring be? Red, white, or pink Mendel’s Experiment Performed experiments using pea plants. Why pea plants? Easy to grow Have easy observable traits Reproduce quickly Pea Plant Traits 1. Flower/ are expressed. For example blood. What are the four blood types? A B AB O ABO Blood Alleles I A – dominant allele for type A blood I B – dominant allele for type B blood i – recessive allele for type O blood ABO Blood Grouping Blood typeGenotype AI A I A/


Blood Typing. What is the use of blood typing? Each person’s blood is different due to the presence of antigens on the surface of red blood cells. Before.

clot, if you get a wound for example. The plasma contains salts and various kinds of proteins. www.freelivedoctor.com Blood Groups, Blood Typing and Blood Transfusions The discovery of blood groups Experiments with blood transfusions, the transfer of blood or blood components into a persons blood stream, have been carried out for hundreds of years. Many patients have died and it was not until 1901, when the Austrian Karl Landsteiner/


2016 ROTARY INTERNATIONAL CONVENTION Korean approach to donor motivation and retention through the Red Cross Society Kim, Sunhee Korean Red Cross Blood.

blood donation and creating intimacy & friendship on blood donation for the future donors located in National Science Museum Can experience Blood Cell Kaleidoscope, Measuring Blood Volume, Quiz, Blood Vessel Experience Rider and etc Operated since April 2014 ABO Blood Donation/the registered blood donors Year2012 2013 2014 2015 No. organizations 187 388677 944 Corporate partners which pledges to donate blood regularly Group (company, public institution, etc) pledges to take part in blood donation movement /


Utilization of Plasma and Plasma derivatives in the perioperative period. Irene Sadek Medical Director Blood Transfusion Services Capital Health.

transfusions have important effects on patients and the health care system. Patients experience adverse transfusion reactions Frozen Plasma, a valuable and scarce resource is used / not be reflective of current performance. FFP vs BC FP Protein Function (ABO matched, n=20) ---------0.0840.960.0841.01 Alpha 2 Antiplasmin >/ forth by a Canadian Expert Working Group in 1997 include only very general recommendations. British Committee for Standards in Haematology, Blood Transfusion Task Force The British Society/


Blood and Immunity Blood and Immunity. Blood Although blood appears to be a thick, homogenous solution, the microscope reveals that it has both cellular.

heart (coronary) will cause heart attack Blood Groups Jean Baptiste Denis was the first to perform a blood transfusion. He injected lamb blood into a young boy successfully. A repeat experiment on an older man proved disastrous /ABO Blood Typing Type A blood has A markers and B antibodies Type B blood has B markers and A antibodies Type AB blood has A and B markers and no antibodies (universal recipient) Type O blood has neither A or B markers but both A and B antibodies (universal donor) ABO Blood Groups/


The Life & Times of RBC. Birthplace  Blood cells are produced in the in the red bone marrow (tissues within the ends of the bone that replaces and produces.

assist to prevent the organism from bleeding to death if it experiences even the smallest of wounds.  They activates some of the first biochemical processes needed to clot blood.  The change of blood from a fluid to a solid is called clotting. Blood Groups  The ABO blood group was the first blood group system discovered, by Landsteiner at the beginning of this century.  Based on 2 antigens (agglutinogens): A & B/


WHAT’S IN YOUR BLOOD?. Facts: The average adult has 4 to 6 quarts of blood in their bodies. The Heart pumps 2000 gallons of blood per day through out.

experience dizziness and fatigue. LEUKOCYTES (WBC) NORMAL COUNT: 5 – 10 THOUSAND LEUKOCYTES CAN PASS THROUGH CAPILLARY WALLS AND ENTER BODY TISSUE SEARCHING OUT PATHOGENS TO ATTACK. MAIN FUNCTION IS TO FIGHT INFECTION. Leukocytes White Blood Cells destroy and engulf pathogens and germs. White Blood/ Everybody has a Blood type. The most common Blood type classification system is the ABO system. There are four types of Blood in the ABO system:  Type A  Type B  Type AB  Type O These groups are based on /


Adverse Effects of Blood Transfusion. Adverse Effects of Blood Transfusion ANY unfavorable consequence is considered an adverse effect of blood transfusion.

Hemolysis Etiology: Antibodies that activate complement to cause hemolysis: ABO antibodies are predominant but not the only ones implicated. Prevention: Give ABO compatible blood. 6 Intravascular Hemolysis Characteristics Reaction begins within minutes of/ (host) tissues. Groups at risk: – Immunocompromised patients(Cancer, fetus, neonatal, bone marrow transplant and HIV). Signs: Fever, dermatitis, or erythroderma, hepatitis, diarrhea, pancytopenia, etc. Prevention: Irradiation of blood products. 28 Delayed /


10 The Foundations of Genetics The foundation for the science of genetics was laid in 1866, when Gregor Mendel used varieties of peas to conduct experiments.

and female reproductive organs, making self-fertilization possible.  It is easy to control which individuals mate. 10 Mendel’s Experiments and the Laws of Inheritance The progeny from the cross of the P parents are called the first filial generation, designated F/a gene are both expressed in the heterozygotes. In the human ABO blood group system the alleles for blood type are I A, I B, and I O. Figure 10.14 ABO Blood Reactions Are Important in Transfusions 10 Alleles and Their Interactions Pleiotropic /


Transmission (Classical, Mendelian) Genetics Ch 11

Transmission (Classical, Mendelian) Genetics Ch 11 Gregor Mendel Experiments in Plant Hybridization, 1865 Simple, controlled, data collection, mathematical analysis Pisum sativum, the garden pea What makes this a/of the MN bloodtype Expected ratio of offspring? 3. Multiple alleles (more than 2 alleles for gene in population) Example: Blood Groups Karl Landsteiner 1900s Chromosome 9 I gene Blood type genotype ABO blood system = polymorphic I gene A IAIA or IAi B IBIB or IBi AB ? O ii What is the mechanism of /


Americas Technical Advisory Group ICCBBA www.iccbba.org ISBT 128 Blood Product Labeling – A Hospital Perspective Americas Technical Advisory Group ICCBBA.

B) Lot number relating to the donor; (C) Product code; and, (D) ABO and Rh of the donor. Copyright ICCBBA, Inc Codabar Labeled Unit Copyright ICCBBA, Inc Why/not unique  Look back - traceability  Consolidating laboratories  Desert Storm experience Susceptible to substitution errors (misreads) Lack of space to incorporate check digits / implementation plan and establish contact with blood supplier(s)  Time frame  Product list  Sample labels  Group planning sessions Identify a transfusion service project/


Lecture 7 blood bank BLOOD TRANSFUSION REACTION Non immunological Dr. Dalia Galal.

after the reaction has taken place. - Re-type the red cells of both donor and recipient for ABO and Rh grouping. - Re-cross match blood from each unit transfused using serum from both pre- and post-transfusion specimens from the patient. Non immunological/ ward or NOT until it is required. 2. Circulatory overload All patient will experience a temporary rise in blood volume and venous pressure following the transfusion of blood or plasma except for those who are actively bleeding. However, young people with /


MCB 140, 12-8-06 1 Quantitative Genetics. MCB 140, 12-8-06 2 A loose distinction “Qualitative” traits: Blood groups (ABO) Coat color in cats Color vision.

8-06 1 Quantitative Genetics MCB 140, 12-8-06 2 A loose distinction “Qualitative” traits: Blood groups (ABO) Coat color in cats Color vision Difference between phenotypes of two individuals can be explained by difference in/person will tend to be taller than an AA bb person). Different traits – i.e., height vs. neuroticism – may be expected to experience these 3 different variances differently. For example (hypothetical), neuroticism may be particularly susceptible to epistasis (item 3) – that is, it doesn’t/


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