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Corso di clinical writing
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What to expect today? Core modules IntroductionIntroduction Correction of abstracts submitted by participantsCorrection of abstracts submitted by participants Practical session 2 – Abstract draftingPractical session 2 – Abstract drafting Results draftingResults drafting Discussion draftingDiscussion drafting Tables and Figures draftingTables and Figures drafting Peer review and publicationPeer review and publication Synthetic example – database creation, analysis and Results draftingSynthetic example – database creation, analysis and Results drafting
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Results What were the findings?
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Results The answer is in the Results.
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Expanded IMRAD Expanded IMRAD algorithm Introduction Background Limitations of current evidence Study hypothesis Methods Design Patients Procedures Follow-up End-points Additional analyses Statistical analysis Results Baseline and procedural data Early outcomes Mid-to-long term outcomes Additional analyses Discussion Summary of study findings Current research context Implications of the present study Avenues for further research Limitations of the present study Conclusions
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Results 1.Logically answer the research question 2.Begin with most important result 3.Correlate with the methods 4.Use data from this study only 5.Present all the representative data (with exact P values and confidence intervals) 6.Use tables, graphs, photographs, and drawings for data
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Results Show subject characteristics as n/N (%) and means± standard deviations (or median [interquartile range) In an intervention: show pre-test means±SD as subject characteristics; show change-score means and SDs to give an impression of any individual responses; show differences in mean changes, with 95% confidence intervals; calculate any individual responses as a standard deviation
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Results Show scattergrams only for a good reason (outliers, non- uniformity of error, non-linear trend): be aware that they can unmask you! Summarize multiple outcomes in a figure or table (Almost) never show test statistics (t, F, 2 ) Try to show chances of clinical/practical substantiveness Avoid repetition of outcomes in figures, tables, or text MOST IMPORTANTLY: do not discuss the findings or interpret them qualitatively!
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Results Supplement rather than repeat data in visuals and tables: –Data must agree within the section and with data given in other sections and visuals Avoid too much dryness and overwhelming the reader with data: –The mean BMI was 10% lower in the 30 tennis players than in the 20 control subjects (respectively 22.5±0.8 vs 24.9±0.7 mm Hg, P=0.035). Should be simply stated (past tense)
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Patient and procedural data Zehetner et al, Surg Endosc 2005
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Patient and procedural data O’Brien et al, Ann Intern Med 2006
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Patient and procedural data Flum et al, JAMA 2005
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Exclusions O’Brien et al, Ann Intern Med 2006
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Early outcomes Nelson et al, NEJM 2004
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Early outcomes O’Brien et al, Ann Intern Med 2006
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Early outcomes Ceelen et al, Ann Surg 2003
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Late outcomes Nelson et al, NEJM 2004
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Late outcomes Ceelen et al, Ann Surg 2003
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Late outcomes Nelson et al, NEJM 2004
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Late outcomes Nelson et al, NEJM 2004
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Do NOTs Use big words that you do not really mean –Attributable –Causality –Preferential –Significant (without statistical evidence) –Validity Mix incidence and prevalence Mix frequency, rate, proportion, ratio
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Questions?
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Take home messages 1.Results should provide a coincise yet poignant synthesis of what you, apparently undexpectedly and independently, have found 2.Results and Discussion should appear as written by two separate individuals!
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And now let’s move to Discussion…
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