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13 October 2005Highligths_Physics1 Production of non-conventional high specific activity radionuclides.

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Presentation on theme: "13 October 2005Highligths_Physics1 Production of non-conventional high specific activity radionuclides."— Presentation transcript:

1 13 October 2005Highligths_Physics1 Production of non-conventional high specific activity radionuclides for biomedical, toxicological and environmental purposes Flavia Groppi, Mauro Bonardi, Luigi Gini Dipartimento di Fisica – UNIMI and INFN Sezione di Milano L.A.S.A. Via F.lli Cervi, Segrate (MI) Enzo Menapace Divisione per le Tecnologie Fisiche Avanzate – ENEA, Bologna Zeev Alfassi Department of Nuclear Engineering, Ben Gurion University, Beer Sheva, Israel Boris Zhuikov Institute for Nuclear Research of Russian Academy of Sciences, Moscow, Russia Kamel Abbas, Uwe Holzwarth, Neil Gibson Institute for Health and Consumer Protection, JRC, EC, Ispra (Va)

2 13 October 2005Highligths_Physics2 Main Research Fields non-conventional high specific activity radionuclides CyclotronNuclear ReactorStudies of non-conventional high specific activity radionuclides by Cyclotron and Nuclear Reactor Quality Control of radiopharmaceutical compounds labelledQuality Control of radiopharmaceutical compounds labelled with short- lived and high specific activity radionuclides: by, and spectrometries, atomic absorption spectrometry, liquid scintillation counting, radioichromatography Accelerator Driven Systems for TransmutationAccelerator Driven Systems for Transmutation of Nuclear Wastes Determination of actinoidsDetermination of actinoids (U, Th, Np, Pu, Am, DU) in biological and environmental matrices,, and spectrometries

3 13 October 2005Highligths_Physics3 Main uses of No Carrier Added Radiotracers

4 13 October 2005Highligths_Physics4 Production of a N.C.A. radionuclide N.C.A. Labelled compound

5 13 October 2005Highligths_Physics5 Origins of Isotopic Carrier (both stable and radioactive)

6 13 October 2005Highligths_Physics6 Recent Projects co-funded by INFN RAME-64 ( ): study of cyclotron production, radiochemical separation and QC of high specific activity copper-64 (copper-61) by deuteron irradiation on natural Zn target ASTATO ( ): study of cyclotron production of astatine-211 (internally spiked by astatine-210) by alpha irradiation on Bi target. Radiochemical separation and QC. Targetry improvement. Polonium- 210 dosimetry ! RENIO (2006–2007): study of cyclotron production of rhenium-186g by proton or deuteron irradiation on W- 186 target. Radiochemical separation and QC.

7 13 October 2005Highligths_Physics7 Nuclear reactions, main nuclear data and applications of radioisotopes used in nuclear medicine under study RadionuclideT 1/2 reactionsgamma emissionsimagingradiotherapy 64 Cu12.70 h nat Zn (d,X) 511 keV PET + and - 61 Cu3.33 h nat Zn (d,X) 511 keV PETimpurity 66 Ga9.49 h nat Zn (d,xn) 511 keV many gammas PET -camera +, 4.2 MeV 186g Re89.25 h 186 W (p,n) 186 W (d,2n) 137 keV other gammas SPET -camera -, 1.1 MeV 211 At 211 Po 7.22 h 516 ms 209 Bi (,2n) X 79 keV -camera, MeV, MeV 210 At 210 Po 8.3 h d 209 Bi (,3n) many gammas -camera internal spike, MeV 225 Ac 213 Bi 213 Po 10.0 d 45.6 m 4.2 s 226 Ra (p,2n)many gammas SPET -camera, MeV, others -, 1.4 MeV, MeV 103 Pd16.97 d 103 Rh (d,2n) X 20,22,23 keV some gammas - - -X 20, 22, 23 keV

8 13 October 2005Highligths_Physics8 211 At production methods JRC-Euratom Ispra cyclotron K = 38 T max /A = K (Z/A) 2 d up to 19 MeV p, up to 38 MeV direct methods Bombarding Bi metallic targets with light ions 209 Bi(, n) 211 At 209 Bi(, 2n) 211 At indirect methods From the decay of its precursor 211 Rn 209 Bi( 6 Li, 4n) 211 Rn 211 At 232 Th(p, spall) 211 Rn 211 At 232 Th(, spall) 211 Rn 211 At I up to 60 A Beam line Irradiation chamber

9 13 October 2005Highligths_Physics9 Decay scheme of 211 At 516 ms 58,2 % 41,8 % E =5.9 MeV 100 % E =7.5 MeV stabile 207 Pb 211g Po 211 At h 207 Bi 31,55 a 100 % 211m Po 25,2 s T 1/2 E S (MeV)Reaction 8,1 h 7,214 h 28, Bi(,3n) 210 At 20, Bi(,2n) 211 At 138,376 d 21, Bi(,d n) 210 Po 15, Bi(,t) 210 Po 23, Bi(,p 2n) 210 Po Decay scheme of 210 At 100 % (on 206 Pb) 138,376 d 210 Po 0,175 % (on 206 Bi) 99,825 % 210 A t 8,1 h E =5,3 MeV The energy of the alpha particles range from 4992 keV to 7451 keV with an average value of 6.22 MeV. The particles of the 211 At/ 211g Po have an average range of 60 m in water (and soft animal tissues), and a nearly optimal LET of 130 eV·nm -1, which is around the maximum of Q curve for energetic ions. The 207 Bi is produced in negligible ammount. The atatine is an alogen: chemistry for labelling molecules is similar to that for iodine.

10 13 October 2005Highligths_Physics10 Dissoluzione del Bi in HNO 3 concentrato Aggiunta alla soluzione di HCl 8 M 1. Dissoluzione del target irraggiato Estrazione in solvente organico etere diisopropilico (o tetracloruro di carbonio) Fase acquosa polonio-210 e Bi Fase organica astato-210,211 Lavaggio con HCl 8 M Ri-estrazione con etere diisopropilico 2.Estrazione liquido/liquido Resa: 98 % Riduzione in forma anionica dellastato con agente riducente (cloruro di idrossilammonio) 3. Ri-estrazione in fase acquosa In alternativa riduzione in forma anionica dellastato in soluzione basica (NaOH) Resa: 50 % Resa: 90 % Radiochemical separations Nuclear measurements (,, spectrometry)

11 13 October 2005Highligths_Physics11 HPGe spectrum – 28.8 MeV irradiation

12 13 October 2005Highligths_Physics12 alpha spectrum after the liquid/liquid extraction: the peaks of both 211 At- 211g Po and 210 Po are shown together (related to 32.8 MeV irradiation). alpha spectrum of the astatine fraction (extracted by the organic solvent): At product is completely extracted from the aqueous solution. alpha spectrum of the separated 210 Po fraction (remained in the aqueous phase): none of the 210 Po is taken into the organic solvent extraction.

13 13 October 2005Highligths_Physics At 210 At 209 Bi(, 3n) 210 At 209 Bi(, 2n) 211 At

14 13 October 2005Highligths_Physics14 Production of 186 Re via (p,n) reaction on 186 W target

15 13 October 2005Highligths_Physics15 Nuclear Physics Laboratory: 4 HPGe connected to 4 MCAs

16 13 October 2005Highligths_Physics16 Nuclear Physics Laboratory: NaI(Tl), spectrometer, Geiger-Müller Liquid Scintillation Counting

17 13 October 2005Highligths_Physics17 Cold Chemistry Laboratory for trace analysis UV-VIS spectrophotometry, polarography-SV, ET-AAS radio-TLC, radio-PC radio-HPLC, radio-GC

18 13 October 2005Highligths_Physics18 Warm Radiochemistry Laboratory: Class II

19 13 October 2005Highligths_Physics19 Warm Radiochemistry Laboratory: Class II

20 13 October 2005Highligths_Physics20 Hot Radiochemistry Laboratory: Class II

21 13 October 2005Highligths_Physics21 Main Collaboarations with Research Centres Institute for Health and Consumer Protection, JRC- Ispra, CE, Varese Centro Radiochimica/Spettroscopia, CNR, Pavia ENEA- Centri di Bologna, Saluggia Dipartimento Scienze Ambientali e Scienze Materiali, Milano-Bicocca Intitute for Nuclear Research, INR, Troitsk, Moskow Region, Russia Los Alamos National Laboratory, USA Ben Gurion University of Beer Sheva, Israel

22 13 October 2005Highligths_Physics22 Hospital Institutions Main Collaborations with Hospital Institutions Istituto Europeo di Oncologia, IEO Servizio Radioterapia e Medicina Nucleare, Milano Ospedale San Paolo, Servizio Medicina Nucleare, Milano Ospedali Riuniti di Bergamo, Servizi Medicina Nucleare e Fisica Sanitaria, Bergamo Ospedale Maggiore-Policlinico, Laboratorio Ciclotrone, Milano Ospedale Niguarda Ca Granda, Servizio Fisica Sanitaria, Milano Istituto Tumori, Milano

23 13 October 2005Highligths_Physics23 Tel: Dipartimento di Fisica – INFN Sezione di Milano Via Fratelli Cervi, 201 – Segrate (MI) Laboratorio LASA-Segrate

24 13 October 2005Highligths_Physics24 Isotopic Carrier : total number of atoms isotopic with main Radio-Nuclide (both radioactive and stable) Isotopic Dilution Factor : IDF = total number of isotopic atoms divided number of atoms of RN Theoretical SA(CF) : SA(CF) = Na / a.m. Specific Activity, SA : SA = Activity of a RN / mass isotopic carrier

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