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Cell Signaling Communication between cells near and far… 1994 Nobel Prize in Physiology/Medicine.

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Presentation on theme: "Cell Signaling Communication between cells near and far… 1994 Nobel Prize in Physiology/Medicine."— Presentation transcript:

1 Cell Signaling Communication between cells near and far… 1994 Nobel Prize in Physiology/Medicine

2 How could cell signalling relate to cancer???

3 Press Release From the reading determine: –What is a G protein? –How does a G protein become activated? –What can G proteins do in a cell? –How does the Cholera toxin affect G-protein signaling? –What is the role of a discriminator? An amplifier?

4 Types of Signaling Paracrine Synaptic Hormonal –Plants –Animals

5 Overview of Cell Signalling Campbell’s 11A –Ligand –Reception –Transduction –Response

6 Types of Receptors Campbell’s 11B –G protein –Tyrosine Kinase –Ligand Gated Ion Channels

7 Signal Transduction Pathways Campbell’s 11C –Second messenger –Protein Kinase

8 Types of Cellular Response Campbell’s 11D; G protein animation http://www.physioviva.com/movies/gpcr/inde x.html –Types of Cellular Responses: Activation of a molecule. Turning on/off protein Gene activation Opening/closing of ioin channels.

9 Activity: G-protein signal transduction You will be part of a g-protein signal pathway. 1.Identify yourself: Reception, Transduction, Cellular Response 2.What is your role?

10 Experiment: Determining Environmental Conditions and Molecules used for signaling Case Study for Chapter 11

11 Human Growth Hormone Connection Normal Activity Altered Activity: Why would Roger Clemens take HgH? Problems associated with taking HgH

12 How is HgH different than testosterone? Testosterone is a steroid –How is the signaling pathway different?

13 Common Link: Destruction of Negative Feedback

14 Followup- -Bitter Taste Why do only some people taste bitter?


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