Presentation is loading. Please wait.

Presentation is loading. Please wait.

Inserm U1216 Research Center – Université Grenoble Alpes

Published byCori Benson Modified over 8 years ago

Similar presentations

Presentation on theme: "Inserm U1216 Research Center – Université Grenoble Alpes"— Presentation transcript:

1 Inserm U1216 Research Center – Université Grenoble Alpes
Director: Frédéric Saudou

2 Our scientific goals To understand the brain
To develop innovative therapies for brain diseases (Alzheimer, Parkinson, Huntington, Epilepsy, Cancer, Schizophrenia, Stroke…) GIN

3 The GIN A Center Dedicated to Fundamental and Clinical Research in Neuroscience “Edmond J. Safra” built in 2007 6000 m2 dedicated to research Located on Grenoble Medical campus Close location to the neurology, psychiatry and neuroscurgery departments and the MRI medical facilities GIN

4 Our institutional partners
Funding and administrative agencies Université Joseph Fourier => Université Grenoble Alpes Institut National pour la Santé et la Recherche Médicale (Inserm) Partners Centre Hospitalier Universitaire (CHU) - Grenoble Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA) European Synchrotron Radiation Facilities (ESFR) Centre National de Recherche Scientifique (CNRS) GIN

5 Our aspirations The GIN as a cutting-edge center for neuroscience with multidisciplinary approaches From molecules to brain signals to decipher brain functions and develop novel therapies

6 Our strategy Our strengths
A continuum from molecules, cells, small animals to human for the study of neurological, neuromuscular and psychiatric disorders Our strengths Cellular and molecular biology of the neuronal cytoskeleton Predictive animal models of brain pathologies Human genetics Functional neurosurgery and deep brain stimulation Functional MRI coupled to electrophysiology Mapping of neuronal networks Cognition and behavior

7 Our opportunities Our strategy
A continuum from molecules, cells, small animals to human for the study of neurological, neuromuscular and psychiatric disorders Our opportunities Grenoble University Hospital Large instruments such as synchrotron Health Engineering (Clinatec, TIMC) Multidisciplinarity with mathematics, physic, imaging centers Neurosciences in Grenoble University Hospital Federation (FHU) Neuropsynov

8 Up to 200 neuroscientists 23 nationalities since 2009 GIN
As of January 2015 23 nationalities since 2009 GIN

9

10 Research teams GIN 2016-2020 9 research teams
Isabelle Arnal Cytoskeleton Dynamics and Structure Annie Andrieux Physiopathology of Cytoskeleton Alain Buisson Neuropathology and Synaptic Dysfunction Isabelle Marty Muscle and Pathologies Antoine Depaulis Synchronization and Modulation of Neuronal Network in Epilepsy Olivier David Brain function and neuromodulation Emmanuel Barbier Functional NeuroImaging and Brain Perfusion Frédéric Saudou Intracellular dynamics and neurodegeneration Sandrine Humbert Neuronal progenitors and brain pathologies (applications for young team leaders are welcome) Mettre les données telle que dans la fiche résumé Unité

11 Evolution of teams GIN 2009-2014 GIN 2016-2020 13 research teams
Isabelle Arnal (AVENIR) Cytoskeleton Dynamics and Structure Annie Andrieux Physiopathology of Cytoskeleton Alain Buisson Neuropathology and Synaptic Dysfunction Rémy Sadoul Neurodegeneration and Plasticity Isabelle Marty Muscle and Pathologies Michel De Waard Calcium Channels, Functions and Pathologies Marc Savasta Dynamic and Pathophysiology of Basal Ganglia Antoine Depaulis Dynamics of synchronous epileptic networks Bruno Bonaz Stress and Neurodigestive Interactions Olivier David Brain function and neuromodulation François Berger Nanotechnology and Brain Emmanuel Barbier Functional NeuroImaging and Brain Perfusion François Estève Synchrotron Radiation and Medical Research GIN 9 research teams Isabelle Arnal (AVENIR) Cytoskeleton Dynamics and Structure Annie Andrieux Physiopathology of Cytoskeleton Alain Buisson Neuropathology and Synaptic Dysfunction Isabelle Marty Muscle and Pathologies Antoine Depaulis Synchronization and Modulation of Neuronal Network in Epilepsy Olivier David Brain function and neuromodulation Emmanuel Barbier Functional NeuroImaging and Brain Perfusion Frédéric Saudou Intracellular dynamics and neurodegeneration Sandrine Humbert Neuronal progenitors and brain pathologies Mettre les données telle que dans la fiche résumé Unité

12 Facilities Jan 2015 Transcriptomic Electronic Microscopy IBiSa
Animal housing (Rodent/Primate) Imaging IBiSa – IsdV -> Guarantying the competitiveness of the facilities -> Investing in new technologies

13 Investing in new technologies Imaging facility
Spinning Confocal microscopy/TIRF (large field, 380 k€) Support from Inserm (arrival of Saudou & Humbert teams) Super-resolution microscopy Bettencourt-Schueller prize to Saudou, 250 k€ Engineer position requested 2-Photon technology IBiSa support for new laser & set-up Light-sheet microscopy CUBIC, 3DISCO... prioritization for grants applications Renovation of lab space for an optimized facility (“PIC-GIN”) SAFRA donation to the GIN Biphoton Zeiss 7MP + … Light sheet micro Airy Scan Frigo 80 60 8,3 m2 5,4 m2 13,8 m2 O2 Air 2,86 m 9,86 m2 2,9 m 1 2 3 4 6 5

14 Translational and clinical research Brain samples from epileptic patients
Sophie Hamelin, MD-PhD, Neurologist Pre-operative investigations at Grenoble University Hospital Resective surgery History Clinical Video-EEG Stereo-EEG MRI PET MEG Frozen samples for : Transcriptomic Immunolabeling Cell culture

15 Translational and clinical research Huntington’s disease working team
A care circuit for Huntington’s disease patients Coordination: Elena MORO Multidisciplinary approach for patients care Neurologists Psychiatrists Geneticists Psychologists Insertion into NeuroPsynov FHU Interaction with basic, preclinical and clinical research groups Cell and molecular mechanisms Mouse models Experimental medicine & clinical testings

16 Neurostimulation and innovations
in refractory neuro-psychiatric diseases NEUROPSYNOV Director : Philippe Kahane Deputy directors: Thierry Bougerol, Stéphan Chabardès RNPD can be studied together Shared: Symptoms and comorbidities Dysfunctions Neural networks Multidisciplinary expertise Common diagnostic tools Translational research

17 NEUROPSYNOV consortium
GIN INSERM-U836 UJF Neuroimaging Neurobiology Animal models 18 research teams GIPSA-Lab CNRS-UMR5216 INPG-UJF-Stendhal Signal processing LPNC CNRS-UMR5105 UPMF Cognitive sciences NEUROPSYNOV consortium Hospital Psychiatry Neurology (Epi) Neurology (MD) Neurosurgery Neuropsychology Neurophysiology Neuroradiology 7 clinical teams CIC Addictology Physical Med. Nuclear Med. Genetics 10 core facilities CLINATEC Experimental neurosurgery Synchrotron ESRF LIPhy CNRS Morpheo INRIA Néel Institute 3 research federations SFR RMN UMS IRMaGe SFR PGC SFR HS University campus CHUG Interface physique-santé Background Objectives Partners Structuration Management Achievements Added value

18 Education in Neuroscience
International Research Master 2 in Neuroscience 3 PhD programs : Life Sciences (Neuroscience) Physics Health Engineering, Cognition PhD students committee : “Neurodocs” Students seminars, workshops, trainings Public information (e.g.: the brain’s week) GIN

19 Communication Interface between science & society
Internal communication: Newsletter for the GIN Internal booklet of ressources and competences External communication New Website Communication manager Targeting general public and medias

Download ppt "Inserm U1216 Research Center – Université Grenoble Alpes"

Similar presentations

Destination Europe Virginie van Wassenhove, PhD

Destination Europe Virginie van Wassenhove, PhD
NEMESIS: image and signal processing for neuroscience Institut du Cerveau et de la Moelle épinière CRICM – CNRS UMR 7225 – Inserm UMR_S975.

NEMESIS: image and signal processing for neuroscience Institut du Cerveau et de la Moelle épinière CRICM – CNRS UMR 7225 – Inserm UMR_S975.
Institute of Neurodegenerative Diseases CNRS-Université Victor Ségalen-Bordeaux 2 Thomas Boraud MD, PhD Neural substrates.

Institute of Neurodegenerative Diseases CNRS-Université Victor Ségalen-Bordeaux 2 Thomas Boraud MD, PhD Neural substrates.
Medical School of Strasbourg and University of Strasbourg

Medical School of Strasbourg and University of Strasbourg
EMBO/EMBL Heidelberg, Germany November 2006 From Genetics to Neuroethics: Is Imaging “Visualizing” Human Thought? Judy Illes, Ph.D. Program in Neuroethics.

EMBO/EMBL Heidelberg, Germany November 2006 From Genetics to Neuroethics: Is Imaging “Visualizing” Human Thought? Judy Illes, Ph.D. Program in Neuroethics.
Sarah Kehoe, Research Assistant Canadian Dementia Knowledge Translation Network

Sarah Kehoe, Research Assistant Canadian Dementia Knowledge Translation Network
Toward the Paris-Saclay University 17/12/2014 toward the UPSay Jean Zinn-Justin Since at least two decades, at the government level, there is constant.

Toward the Paris-Saclay University 17/12/2014 toward the UPSay Jean Zinn-Justin Since at least two decades, at the government level, there is constant.
Warsaw Ochota Campus BioInfoMed Research Centre Warsaw Ochota Campus BioInfoMed Research Centre Jerzy Duszyński Marcin Szumowski.

Warsaw Ochota Campus BioInfoMed Research Centre Warsaw Ochota Campus BioInfoMed Research Centre Jerzy Duszyński Marcin Szumowski.
Pathway to a GW4 collaboration Brain networks in health and disease.

Pathway to a GW4 collaboration Brain networks in health and disease.
Bioscience/Biomedical Research at Idaho State University Christopher Daniels, Ph.D. Director, ISU Biomedical Research Institute and Professor of Pharmaceutical.

Bioscience/Biomedical Research at Idaho State University Christopher Daniels, Ph.D. Director, ISU Biomedical Research Institute and Professor of Pharmaceutical.
Helena Chui, M.D. McCarron Professor and Chair of Neurology Director, Alzheimer Disease Research Center.

Helena Chui, M.D. McCarron Professor and Chair of Neurology Director, Alzheimer Disease Research Center.
Medical College of Wisconsin Functional Imaging Research Center Stephen M. Rao, Ph.D., Director Professor of Neurology

Medical College of Wisconsin Functional Imaging Research Center Stephen M. Rao, Ph.D., Director Professor of Neurology
Bindley Bioscience Center Vision: Nurture interactive communication and interdisciplinary discovery with flexible laboratory project spaces and an open.

Bindley Bioscience Center Vision: Nurture interactive communication and interdisciplinary discovery with flexible laboratory project spaces and an open.
Biomedical Research Networking Center Consortium (CIBER) Opportunities of collaboration with CIBERSAM R&D&I collaborations  Innovation in drugs  Innovation.

Biomedical Research Networking Center Consortium (CIBER) Opportunities of collaboration with CIBERSAM R&D&I collaborations  Innovation in drugs  Innovation.
Understanding Neurons and the Circuitry of the Brain Jonathan H. Manton The University of Melbourne November 2008.

Understanding Neurons and the Circuitry of the Brain Jonathan H. Manton The University of Melbourne November 2008.
ICARE Member Reports ETP seeks to improve incentives and encourage commercial investment in new therapies. (Treatments reach patients only by commercial.

ICARE Member Reports ETP seeks to improve incentives and encourage commercial investment in new therapies. (Treatments reach patients only by commercial.
The NIH Roadmap for Medical Research www.nihroadmap.nih.gov www.nihroadmap.nih.gov.

The NIH Roadmap for Medical Research
School of Medicine Shared Resource Facilities The School of Medicine provides direct support and oversight to 21 SOM shared resource facilities. Their.

School of Medicine Shared Resource Facilities The School of Medicine provides direct support and oversight to 21 SOM shared resource facilities. Their.
Institute of Living Systems.  Neuroscience Center  Laboratory of Stem Cells Research and Regenerative Medicine  Laboratory of Experimental Oncology.

Institute of Living Systems.  Neuroscience Center  Laboratory of Stem Cells Research and Regenerative Medicine  Laboratory of Experimental Oncology.
Michael P. Kilgard Healing the Human Brain: The Next Medical Revolution University of Texas at Dallas.

Michael P. Kilgard Healing the Human Brain: The Next Medical Revolution University of Texas at Dallas.

Similar presentations

Ads by Google