1. www.ias2013.org Kuala Lumpur, Malaysia, 30 June - 3 July 2013 MOPDB0101 Cardiovascular abnormalities and carotid intima-media thickness (cIMT) among HIV-infected adolescents receiving long-term highly antiretroviral therapy in Thailand: A cross-sectional study with HIV-uninfected healthy controls Voraporn Poomlek, MD 1, Prakul Chanthong, MD 1, Keswadee Lapphra, MD 1, Supawan Saihongthong, MD 1, Kulkanya Chokephaibulkit, MD 1 1 Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

2. www.ias2013.org Kuala Lumpur, Malaysia, 30 June - 3 July 2013 Methods Echocardiogram and cIMT measurement by carotid ultrasound were performed in – 100 HIV-infected adolescents receiving stable ART for at least 6 months, and without apparent cardiovascular condition – 50 Healthy adolescent controls A blood drawn for lipid, hs-CRP, CD4, VL CharacteristicsHIV-infected (n=100) Healthy controls (n=50) P-value Sex; male (%)56%48%0.36 Median age (range)15.5 (12-20.4)16.15 (12.1-19.4)0.29 Nadir CD4 count (cell/mm 3 )94 (2-3,010) Current CD4 count (cell/mm 3 )654 ( 54-1,811) % HIV-1 RNA<40 copies/ml (%)82 (82.0%) Current regimen with PIs - PI based - NNRTI + PI based 39 (39.0) 10 (10.0)

3. www.ias2013.org Kuala Lumpur, Malaysia, 30 June - 3 July 2013 HIV-infected (N=100) Healthy controls (N=50) P-value No. of chol > 200 mg/dl, n (%) No. of TG > 150 mg/dl, n (%) No. of HDL < 35 mg/dl, n (%) 25(25.0) 37 (37.0) 8 (8.0) 12 (24.0) 1 (2.0) 0 (0) 0.867 <0.001 0.017 No. with hs-CRP > 3.0 g/dl22 (22.0)4 (8.0)0.039 LVIMP0.3 (0.05-0.53)0.24 (0.06-0.47)0.004 Overall cIMT (mm.)0.373(0.284-0.451)0.371(0.324-0.446)0.744 Results Receiving PI > 6 months (n=53) Receiving PI < 6 months (n=47) P-value Overall cIMT (mm.)0.379 (0.284-0.451)0.372 (0.287-0.423)0.02 Conclusions HIV-infected had higher rate of hypertriglyceride level and hypoHDL No difference in cIMT among HIV-infected adolescents and healthy adolescent controls Among HIV-infected adolescents, receiving PI treatment > 6 months was associated with increased overall cIMT