1. 12.02.15 Catalyst You are at a Wild game and Nordy launches a t- shirt at your head. You blink just as the shirt/projectile gets close but catch it anyways! Explain what happened on a neurological level. 1

2. Today! Neurons & Action Potential Complete Lab 2

3. Fig. 49-17 Generating words Max Speaking words Hearing words Seeing words Min

4. Fig. 48-4 Presynaptic cell

5. Fig. 48-4 Stimulus Presynaptic cell

6. Fig. 48-4 Dendrites Stimulus Presynaptic cell

7. Fig. 48-4 Dendrites Stimulus Nucleus Presynaptic cell

8. Fig. 48-4 Dendrites Stimulus Nucleus Cell body Presynaptic cell

9. Fig. 48-4 Dendrites Stimulus Nucleus Cell body Axon hillock Presynaptic cell

10. Fig. 48-4 Dendrites Stimulus Nucleus Cell body Axon hillock Presynaptic cell Axon

11. Fig. 48-4 Dendrites Stimulus Nucleus Cell body Axon hillock Presynaptic cell Axon Postsynaptic cell

12. Fig. 48-4 Dendrites Stimulus Nucleus Cell body Axon hillock Presynaptic cell Axon Synaptic terminals Postsynaptic cell

13. Fig. 48-4 Dendrites Stimulus Nucleus Cell body Axon hillock Presynaptic cell Axon Synaptic terminals Synapse Postsynaptic cell

14. Fig. 48-4 Dendrites Stimulus Nucleus Cell body Axon hillock Presynaptic cell Axon Synaptic terminals Synapse Postsynaptic cell Neurotransmitter

15. Fig. 48-5a Dendrites Axon Cell body Sensory neuron

16. Fig. 48-5b Interneurons Portion of axon Cell bodies of overlapping neurons 80 µm

17. Fig. 48-5d Motor neuron

18. Sensory Neuron Investigation… Progress so far? Complete it! Lab due Thursday Friday

19. Fig. 48-6b (b) OUTSIDE CELL Na + Key K+K+ Sodium- potassium pump Potassium channel Sodium channel INSIDE CELL

20. Fig. 48-9c Strong depolarizing stimulus +50 Membrane potential (mV) –50Threshold Resting potential –100 02 3 4 Time (msec) (c) Action potential 1 5 0 Action potential 6

21. Fig. 48-10-1 Key Na + K+K+ +50 Action potential Threshold 0 1 4 5 1 –50 Resting potential Membrane potential (mV) –100 Time Extracellular fluid Plasma membrane Cytosol Inactivation loop Resting state Sodium channel Potassium channel Depolarization 2 3 1

22. Fig. 48-10-2 Key Na + K+K+ +50 Action potential Threshold 0 1 4 5 1 –50 Resting potential Membrane potential (mV) –100 Time Extracellular fluid Plasma membrane Cytosol Inactivation loop Resting state Sodium channel Potassium channel Depolarization 2 3 2 1

23. Fig. 48-10-3 Key Na + K+K+ +50 Action potential Threshold 0 1 4 5 1 –50 Resting potential Membrane potential (mV) –100 Time Extracellular fluid Plasma membrane Cytosol Inactivation loop Resting state Sodium channel Potassium channel Depolarization Rising phase of the action potential 2 3 2 1 3

24. Fig. 48-10-4 Key Na + K+K+ +50 Action potential Threshold 0 1 4 5 1 –50 Resting potential Membrane potential (mV) –100 Time Extracellular fluid Plasma membrane Cytosol Inactivation loop Resting state Sodium channel Potassium channel Depolarization Rising phase of the action potential Falling phase of the action potential 2 3 2 1 3 4

25. Fig. 48-10-5 Key Na + K+K+ +50 Action potential Threshold 0 1 4 5 1 –50 Resting potential Membrane potential (mV) –100 Time Extracellular fluid Plasma membrane Cytosol Inactivation loop Resting state Sodium channel Potassium channel Depolarization Rising phase of the action potential Falling phase of the action potential 5 Undershoot 2 3 2 1 3 4

26. Fig. 48-11-1 Axon Plasma membrane Cytosol Action potential Na +

27. Fig. 48-11-2 Axon Plasma membrane Cytosol Action potential Na + Action potential Na + K+K+ K+K+

28. Fig. 48-11-3 Axon Plasma membrane Cytosol Action potential Na + Action potential Na + K+K+ K+K+ Action potential K+K+ K+K+ Na +

29. Fig. 48-12 Axon Schwann cell Myelin sheath Nodes of Ranvier Node of Ranvier Schwann cell Nucleus of Schwann cell Layers of myelin Axon 0.1 µm

30. Fig. 48-13 Cell body Schwann cell Depolarized region (node of Ranvier) Myelin sheath Axon Saltatory conduction

31. Fig. 48-15 Voltage-gated Ca 2+ channel Ca 2+ 1 2 3 4 Synaptic cleft Ligand-gated ion channels Postsynaptic membrane Presynaptic membrane Synaptic vesicles containing neurotransmitter 5 6 K+K+ Na +

32. Table 48-1