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Influenza Vaccine Responses Roland A. Levandowski, M.D. Division of Viral Products Prepared for Vaccines and Related Biological Products Advisory Committee.

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Presentation on theme: "Influenza Vaccine Responses Roland A. Levandowski, M.D. Division of Viral Products Prepared for Vaccines and Related Biological Products Advisory Committee."— Presentation transcript:

1 Influenza Vaccine Responses Roland A. Levandowski, M.D. Division of Viral Products Prepared for Vaccines and Related Biological Products Advisory Committee 16-17 February 2005

2 1. ALAN HAMPSONADULTA/NEW CALEDONIA/20/99-LIKE (H1N1) WHO, AUSTRALIAELDERA/WYOMING/3/2003 (H3N2) B/BRISBANE/32/2002 2. JOHN WOOD, PH.DADULTA/NEW CALEDONIA/20/99 (H1N1) NIBSC, ENGLANDELDERA/WYOMING/3/2003 (H3N2) B/JIANGSU/10/2003 3. TAKATO ODIGARI, PH.D. ADULTA/NEW CALEDONIA/20/99-LIKE (H1N1) WHO, JAPANELDERA/WYOMING/3/2003 (H3N2) B/SHANGHAI/361/2003 Serum Panels for Serologies

3 4. STEFAN GRAVENSTEIN, M.D.ADULTA/NEW CALEDONIA/20/99 (H1N1) EASTERN VIRGINIA ELDERA/WYOMING/3/2003 (H3N2) MEDICAL SCHOOLCHILDB/JIANGSU/10/2003 5.WILLIAM KOCH, M.D.CHILDA/NEW CALEDONIA/20/99 (H1N1) VIRGINIA COMMONWEALTHA/WYOMING/3/2003 UNIVERSITYB/JIANGSU/10/2003

4 ANTIGENS FOR SEROLOGIES (H1) VACCINE STRAIN A/NEW CALEDONIA/20/99 (H1N1) REPRESENTATIVE CURRENT STRAINS A/BANGKOK/1544/2004 (H1N1) A/FLORIDA/4/2004 (H1N1) A/NETHERLANDS/128/2004 (H1N1) A/NEW CALEDONIA/9/2004 (H1N1) A/OKINAWA/42/2004 (H1N1) A/SAITAMA/78/2004 (H1N1) A/SINGAPORE/14/2004 (H1N1)

5 HI ANTIBODY RESPONSES TO THE H1 COMPONENT 2004-2005 INFLUENZA VACCINE ADULT POPULATION (CBER)

6 HI ANTIBODY RESPONSES TO THE H1 COMPONENT 2004-2005 INFLUENZA VACCINE ELDERLY POPULATION (NIBSC)

7 HI ANTIBODY RESPONSES TO THE H1 COMPONENT 2004-2005 INFLUENZA VACCINE PEDIATRIC POPULATION (CDC AND CBER)

8 A/NEW CALEDONIA/20/99 VACCINES SUMMARY TABLE VIRUSES WITH > 50% GMT REDUCTION

9 ANTIGENS FOR SEROLOGIES (H3) VACCINE STRAIN A/WYOMING/3/2003 REPRESENTATIVE CURRENT STRAINS A/BANGKOK/1563/2004 A/CALIFORNIA/7/2004 A/OSAKA/36/2004 A/OSLO/8/2004 A/SHANTOU/1219/2004 A/SINGAPORE/36/2004 A/SINGAPORE/37/2004 A/TENNESSEE/6/2004 A/TOKYO/1035/2004 A/VICTORIA/523/2004

10 HI ANTIBODY RESPONSES TO THE H3 COMPONENT 2004-2005 INFLUENZA VACCINE ADULT POPULATION ( CDC )

11 HI ANTIBODY RESPONSES TO THE H3 COMPONENT 2004-2005 INFLUENZA VACCINE ELDERLY POPULATION (NIBSC)

12 HI ANTIBODY RESPONSES TO THE H3 COMPONENT 2004-2005 INFLUENZA VACCINE PEDIATRIC POPULATION (CDC AND CBER)

13 A/WYOMING/3/2003 VACCINES SUMMARY TABLE VIRUSES WITH > 50% GMT REDUCTION

14 ANTIGENS FOR SEROLOGIES (B) VACCINE STRAIN B/BRISBANE/32/2002* B/JIANGSU/10/2003+ REPRESENTATIVE CURRENT STRAINS B/HAWAII/13/2004* B/PHITSANULOK/2053/2004* B/COLORADO/4/2004+ B/FLORIDA/7/2004+ B/FUJIAN/430/2004+ * = HONG KONG/330-LIKE B/LISBON/1/2004+ + = SHANGHAI/361-LIKE B/SHIZUOKA/2/2004+ B/SHIZUOKA/58/2004+ B/VICTORIA/501/2004+

15 HI ANTIBODY RESPONSES TO THE B COMPONENT 2004-2005 INFLUENZA VACCINE ADULT POPULATION (CDC)

16 HI ANTIBODY RESPONSES TO THE B COMPONENT 2004-2005 INFLUENZA VACCINE ELDERLY POPULATION (AUS)

17 HI ANTIBODY RESPONSES TO THE B COMPONENT 2004-2005 INFLUENZA VACCINE PEDIATRIC POPULATION (CDC AND CBER)

18 B/SHANGHAI/361/2002-LIKE VACCINES SUMMARY TABLE VIRUSES WITH > 50% GMT REDUCTION

19 Influenza Vaccine Responses Summary Studies with sera collected after immunization with current vaccines show that: Representative influenza A (H1N1) viruses are well-inhibited A/California/7/2004 (H3N2)-like viruses are poorly inhibited compared to the vaccine strain B/Shanghai/361/2002-like viruses are reasonably well-inhibited but B/Hong Kong/330/2001-like viruses are less well inhibited than the vaccine strains

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