1. 12.09.15 Catalyst Name three things that can cause disease (pathogens). I will review the function of the immune system.

2. Today Brief notes Auto-immune disease detail choice Work time/questions on packet

3. Innate immunity – present before any exposure to pathogens and is effective from the time of birth – Involves nonspecific responses to pathogens Figure 43.1 3m3m

4. Acquired immunity AKA adaptive immunity – Develops only after exposure to inducing agents such as microbes, toxins, or other foreign substances – Specific response to pathogens

5. A summary of innate and acquired immunity INNATE IMMUNITY Rapid responses to a broad range of microbes ACQUIRED IMMUNITY Slower responses to specific microbes External defensesInternal defenses Skin Mucous membranes Secretions Phagocytic cells Antimicrobial proteins Inflammatory response Natural killer cells Humoral response (antibodies) Cell-mediated response (cytotoxic lymphocytes) Invading microbes (pathogens) Figure 43.2

7. The allergic response Figure 43.20 IgE antibodies produced in response to initial exposure to an allergen bind to receptors or mast cells. 1 On subsequent exposure to the same allergen, IgE molecules attached to a mast cell recog- nize and bind the allergen. 2 Degranulation of the cell, triggered by cross-linking of adjacent IgE molecules, releases histamine and other chemicals, leading to allergy symptoms. 3 1 2 3 Allergen IgE Histamine Granule Mast cell

8. Autoimmune Diseases The immune system loses tolerance for self and turns against certain molecules of the body.

9. Auto-immune Diseases - Details Choose 2 diseases and take note of: Cause (how do you get it) treatment symptoms frequency When finished complete or ask questions on yesterday’s packet!