Presentation is loading. Please wait.

Presentation is loading. Please wait.

Homologous morcelized defatted bone graft additionated with antibiotic and PMMA in vivo: preliminary histologic evaluation. G. Gualdrini. Rizzoli Institute.

Similar presentations


Presentation on theme: "Homologous morcelized defatted bone graft additionated with antibiotic and PMMA in vivo: preliminary histologic evaluation. G. Gualdrini. Rizzoli Institute."— Presentation transcript:

1 Homologous morcelized defatted bone graft additionated with antibiotic and PMMA in vivo: preliminary histologic evaluation. G. Gualdrini. Rizzoli Institute VII Department of Orthopaedic and Traumatology Orthopaedic Clinic - University of Bologna - Italy Orthopaedic Clinic - University of Bologna - Italy Director prof. Armando Giunti

2 1947 De Grood M De Grood M McCollum D.E McCollum D.E Roffmann M Roffmann M Sloof T Sloof T Ling R Ling R Oakeshott R Oakeshott R Oliver H Oliver H Gie GA Gie GA Schreurs B.W Schreurs B.W.

3 1996 Hovelius e Ullmark Impacted morselized allograft and cement for revision total knee arthroplasty Acta Orthop. Scand. 1996

4 1998 Bone Bank Rizzoli Institute Omologous morcelized defatted bone graft

5

6 Chips 3 mm

7 Thorèn K.:, Thorèn K.: Lipid-extracted bone graft, 1994.

8 three sterile envelops three sterile envelops 25 kGy, 25 kGy, - 80° C, - 80° C,

9 4 weeks With G. Ullmark kind permit

10 6 months With G. Ullmark kind permit

11 4 years With G. Ullmark kind permit

12 4 years With G. Ullmark kind permit

13 82 hip p. revisions 6 knee p. revisions 13 post-trauma hip prosthesis 51 spinal fusions 50 bone lesions filling 47 long bone non-unions 249 patients 10/ /2002

14 Paprosky 2B

15

16 Paprosky 3B

17

18 3 months 2 years

19 GCT

20

21 12 months

22 Bone cyst 1month p.o.

23 3 months 6 months

24 High plastic propertiesHigh plastic properties Loss bone-stock recoveryLoss bone-stock recovery High resistance to septic riskHigh resistance to septic risk Low resistance to mechanical strenghtLow resistance to mechanical strenght Remarks about MOD-B

25 Adsorption and release of antibiotics from morselized cancellous bone. In vitro studies of 8 antibiotics. Witso E., Persen L., Loseth K., Bergh K. Acta Orthop. Scand Jun; 70 (3): Vancomycin-Tobramycin composite grafts -a new treatment for chronic osteomyelytis of the neuropatic food. Winkler H., Berger C., Kristen K.H., Engel A. Annual Meeting EBJIS, May 25-27, 2000 Berlin.

26 inserire rx tappari, avambracci, Navacchia

27 Morcelized bone combined with acrylic cement enhances in vitro release of vancomycin VII Department Orthopaedic and Traumatology *Muscoloskeletal Tissue Bank Rizzoli Orthopaedic Institute, Bologna. G.Gualdrini, A.Bassi*, A. Giunti in press

28

29 16 cylinders: 10 C-A-MB : PMMA g vancomycin g bone g C-A : PMMA g vancomycin g 0.1

30 Human plasma Saline solution Four weeks 37°C Human plasma Saline solution Four weeks 37°C

31 Antibiotic total release bone pla vs cem pla p=0.04

32 Antibiotic release first week

33 Antibiotic release second-fourth week

34 Mechanical characterization of an antibiotic cement-morcelized bone graft composite M.Baleani, R.Fognani, A.Toni, A.Bassi°, G.Gualdrini* Medical Tecnology Lab.- I Orthopaedic Department °Muscoloskeletal Tissue Bank *VII Orthopaedic Department Rizzoli Orthopaedic Institute, Bologna. In press.

35

36

37 Homologous morcelized defatted bone graft additionated with antibiotic and PMMA in vivo: preliminary histologic evaluation. G.Gualdrini, A.Bassi, A.Giunti.

38

39

40

41

42 High plastic propertiesHigh plastic properties Loss bone-stock recoveryLoss bone-stock recovery Good antibiotic deliveryGood antibiotic delivery High resistance to mechanical loadingHigh resistance to mechanical loading Good in vivo biocompatibilityGood in vivo biocompatibility Remarks about CAMB

43


Download ppt "Homologous morcelized defatted bone graft additionated with antibiotic and PMMA in vivo: preliminary histologic evaluation. G. Gualdrini. Rizzoli Institute."

Similar presentations


Ads by Google