1. Esther Bokhobza estherbokhobza@gmail.com Immunology.unideb.hu
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2. Why Immunology for Pharmacists??
Agents acting on the Immune system:
Non-steroidal anti-inflammatory drugs (NSAIDs)
Antihistamines
Salicylates
Immunomodulation; drugs that activate or suppress the immune system

3. Keep in mind Many anti-inflammatory drugs are available over the counter so there is a potential for abuse and overdosing. 2.Patients on anti-inflammatory drugs block the signs and symptoms of a condition, sometimes, make it hard to correctly diagnose. 3. Patients might combine these drugs and unknowingly induce toxicity.

4. NSAIDs
Flurbiprofen
Ibuprofen
Naproxen
Diclofenac

5. Mesalazine / Mesalamine
Salicylates
ASA
Mesalazine- inflammatory bowel diseases; ulcerative colitis, Chron’s disease.
Mesalazine / Mesalamine

6. Immunosuppressant drugs T cell inhibitors and anti-proliferative drugs
Tacrolimus
Mycophenolate mofetil
Cyclosporin
Sirolimus/Rapamycin
Tacrolimus and sirolimus- prevent rejection of a transplant. Block IL-2 response.
Mycophenolate mofetil- organ transplant rejection, autoimmune diseases. Inhibit T and B cell growth.
Cyclosporin and azathioprine- prevent rejection of a transplanted organ and act against autoimmune diseases.
Cyclophosphamide- lymphomas, leukemia, brain cancers. Autoimmune diseases; DMARD.
Azathioprine
Methotrexate
Cyclophosphamide

7. Immunosuppressant drugs Glucocorticoids
Prednisolone
Methylprednisolone
Budesonide
Triamcinolone
betamethasone

8. Immunosuppressant drugs Leukotriene antagonists
Leukotrienes are very important agents in the inflammatory response. Some, such as LTB4 have a chemotactic effect on migrating neutrophils, and as such help to bring the necessary cells to the tissue. Leukotrienes also have a powerful effect in bronchoconstriction and increase vascular permeability. These antagonists are advised for the prevention of allergic asthma.
Montelukast
Zafirlukast
Zileuton

9. Antibodies IL-2R antagonists Efalizumab Rho (D) immunoglobin
Daclizumab and Basiliximab- binds IL-2 Rs on T cells. For prevention of organ rejection.
Efalizumab- Withdrawn.
IL-2R antagonists
Basiliximab
Daclizumab

10. Immunostimulant drugs
Imiquimod
IL-2
Imiquimod- Skin and genitalia cancers. Activates macrophages, NK cells and B cells through TLR7 causing IL-6, TNF-α and INF-α.
IFNs- Hepatitis C treatment.
IL-2- Chronic viral infections, HIV.
Peginterferon alpha 2a
Peginterferon alpha 2b