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Realistic modeling the cerebellar cortex

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1 Realistic modeling the cerebellar cortex
OPEN SOURCE BRAIN Realistic modeling the cerebellar cortex Sergio Solinas, Egidio D’Angelo University of Pavia IRCCS C. Mondino Alghero May 2013

2 1958

3

4 “a lattice” 55 years later
OSB website

5 Parasagittal organization Golgi cell axon
Barmack & Yakhnitsa J. Neurosci. 2008

6 Parasagittal organization Mossy fiber branching
Wu et al. J. Comparative Neurology 1999

7 Lattice arrangement Purkinje cell dendritic fields Stellate cell
axonal field Golgi cell axonal field Parallel fibers Golgi cell dendritic field Pellionisz & Szentágothai Brain Research 1973

8 Network picture from otto

9 Input of the cerebellar cortex
Convey channel: Cerebral cortex Sensory nuclei

10 Center/ surround effect
Spot scale 200 µm

11 Parallelf fiber scale 2 mm: Lateral inhibition

12 Collaborative development
Sheffield: tests and analysis procedures Amrita: LFP reconstruction & Multicompartmenteal GRC model

13 Field Programmable Gate Array (FPGA) PhD Thesis Alessandra Majani
Hart beat discrimination F1 engine monitor NEURON simulator

14 FPGA simulator Single compartment model of Cerebellar granule cell (D’Angelo et al. 2001, Solinas et al .2010)

15 FPGA simulator Architecture N° CELLs FPGA complexity Expandable SOFTWARE 100 LOW YES HARDWARE 1 300 NO HARDWARE 2 150 HIGH LIMITS HARDWARE 3 MEAN HARDWARE 4

16 Neurophysiology Lab in Pavia
Brain Connectivity Center IRCCS C. Mondino Egidio D’Angelo Francesca Prestori Lisa Mapelli Daniela Gandolfi (Modena) Jonathan Mapelli (Modena) Francesca Locatelli Luigi Congi Ramakrishnan K. B. Licia de Propris Martina Sgritta Martina Pagani Paolo Pozzi Jesus Garrido Stefano Masoli Sathyaa Subramaniyam Timoteo Colnaghi Fulvia Palesi Gloria Castellazzi Jessica Monaco Stefano Casali Alessandra Majani Irene Solinas Leda Ruggeri


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