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Realistic modeling the cerebellar cortex Sergio Solinas, Egidio DAngelo University of Pavia IRCCS C. Mondino Alghero 13-15 May 2013 OPEN SOURCE BRAIN.

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Presentation on theme: "Realistic modeling the cerebellar cortex Sergio Solinas, Egidio DAngelo University of Pavia IRCCS C. Mondino Alghero 13-15 May 2013 OPEN SOURCE BRAIN."— Presentation transcript:

1 Realistic modeling the cerebellar cortex Sergio Solinas, Egidio DAngelo University of Pavia IRCCS C. Mondino Alghero May 2013 OPEN SOURCE BRAIN

2 1958

3

4 OSB website a lattice 55 years later

5 Parasagittal organization Golgi cell axon Barmack & Yakhnitsa J. Neurosci. 2008

6 Parasagittal organization Mossy fiber branching Wu et al. J. Comparative Neurology 1999

7 Lattice arrangement Pellionisz & Szentágothai Brain Research 1973 Purkinje cell dendritic fields Stellate cell axonal field Golgi cell axonal field Parallel fibers Golgi cell dendritic field

8 Network picture from otto

9 Convey channel: Cerebral cortex Sensory nuclei Input of the cerebellar cortex

10 Spot scale 200 µm Center/ surround effect

11 Parallelf fiber scale 2 mm: Lateral inhibition

12 Collaborative development Sheffield: tests and analysis procedures Amrita: LFP reconstruction & Multicompartmenteal GRC model

13 Field Programmable Gate Array (FPGA) PhD Thesis Alessandra Majani NEURON simulator Hart beat discrimination F1 engine monitor

14 FPGA simulator Single compartment model of Cerebellar granule cell (DAngelo et al. 2001, Solinas et al.2010)

15 FPGA simulator ArchitectureN° CELLsFPGA complexityExpandable SOFTWARE100LOWYES HARDWARE 1300LOWNO HARDWARE 2150HIGHLIMITS HARDWARE MEANYES HARDWARE MEANLIMITS

16 Neurophysiology Lab in Pavia Brain Connectivity Center IRCCS C. Mondino Egidio DAngelo Francesca Prestori Lisa Mapelli Daniela Gandolfi (Modena) Jonathan Mapelli (Modena) Francesca Locatelli Luigi Congi Ramakrishnan K. B. Licia de Propris Martina Sgritta Martina Pagani Paolo Pozzi Jesus Garrido Stefano Masoli Sathyaa Subramaniyam Timoteo Colnaghi Fulvia Palesi Gloria Castellazzi Jessica Monaco Stefano Casali Alessandra Majani Irene Solinas Leda Ruggeri


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