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Sensitization index Keratinocytes NCTC2544 Irritation index Haptenation Resorption.

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Presentation on theme: "Sensitization index Keratinocytes NCTC2544 Irritation index Haptenation Resorption."— Presentation transcript:

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2 Sensitization index Keratinocytes NCTC2544 Irritation index Haptenation Resorption

3 Haptenation Sensitization index Irritation index Xenobiotic Endogenous protein Keratinocyte Dendritic cell (Langerhans cell) T Lymphocyte Interleukin 18

4 Xenobiotic Endogenous protein Keratinocyte Dendritic cell (Langerhans cell) T Lymphocyte Interleukin 18 Resorption Haptenation Sensitization index Irritation index

5 Xenobiotic Endogenous protein Keratinocyte Dendritic cell (Langerhans cell) T Lymphocyte Interleukin 18 Resorption Haptenation Sensitization index Irritation index

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7 Sensitization index Keratinocytes NCTC2544 Irritation index Haptenation Resorption

8 Test molecule

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10 Resorption Sensitization index Keratinocytes NCTC2544 Irritation index Haptenation

11 Test molecule Endogenous protein

12 Irritation index Haptenation Resorption

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18 Sensitization index Keratinocytes NCTC2544 Haptenation Resorption Irritation index

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20 Sensitization index Keratinocytes NCTC2544 Haptenation Resorption Irritation index


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