1. BY KINE LILLEVIK & HENRIK HAGEN Borreliosis in Norway

2. Content 1. Definition 2. Ethiology 3. Epidemiology 4. Symptoms 5. Treatment 6. Discussion & Prediction

3. Definition Vector-borne disease Lyme Disease Old Lyme, Connecticut, US in 1975 Northern Hemisphere

4. Epidemiology

6. 155 cases per 100.000 individuals = 0,155 % 300.000 in the US and 65.000 in Europe (2012) In Norway:

7. Ethology Spirochete Borrelia Burgodorferi 36 known types, 12 infectious Very motile ¼ Ticks

8. Symptoms Early localized infection  Circular oriented rash (70-80%)  Flu-like symptoms Early disseminated infection  Borrelia lymphactoma  Rash  Arytmia  Neuroborreliosis (10-15%)  Facial Palsy, Meningitis, SC inflammation, Mild Encephalitis

9. Symptoms Late disseminated infection (5%)  Chronic Fatigue Syndrome (CFS)  Paraplegia  Polyneuropathy  Encephalomyelitis  Chronic skin diseases  Arthritis

10. Testing & Treatment Testing:  Enzyme linked immunosorbent assay (ELISA)  Western blot test Treatment  Oral antibiotics  Intravenous antibiotics  Vaccine? Preventive precautions

11. Prediction & Discussion Often misdiagnosed Long antibiotic treatments Norwegian Borelliosis center closed Connection to CFS? Vaccine in the making

12. Sources http://www.ncbi.nlm.nih.gov/pubmed/16338759 http://www.fhi.no/dokumenter/759dad3d2c.pdf http://emedicine.medscape.com/article/330178- overview#a4 http://emedicine.medscape.com/article/330178- overview#a4 http://www.mayoclinic.org/diseases- conditions/lyme-disease/basics/treatment/con- 20019701 http://www.mayoclinic.org/diseases- conditions/lyme-disease/basics/treatment/con- 20019701 http://www.mayoclinic.org/diseases- conditions/lyme-disease/basics/tests-diagnosis/con- 20019701 http://www.mayoclinic.org/diseases- conditions/lyme-disease/basics/tests-diagnosis/con- 20019701