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Top Five Papers in Transplant ID 2014-2015 Selected using a Completely Unscientific Polling Method Heavily Influenced by Personal Opinion* Not that of.

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Presentation on theme: "Top Five Papers in Transplant ID 2014-2015 Selected using a Completely Unscientific Polling Method Heavily Influenced by Personal Opinion* Not that of."— Presentation transcript:

1 Top Five Papers in Transplant ID 2014-2015 Selected using a Completely Unscientific Polling Method Heavily Influenced by Personal Opinion* Not that of the presenter, Joanna Schaenman. Shelley Morris just gave me these slides.

2 Method Requested input from TID 2015 speakers Reviewed “Editor’s Picks” & “Most Cited” papers from – American Journal of Transplantation – Transplantation – Clinical Infectious Diseases – New England Journal of Medicine Personal Opinion

3 Newsworthy Items for the Past Year in Transplant ID Application of Hepatitis C Virus Treatment to Transplant Candidates/Recipients Management of Transplant Candidates with Multidrug Resistant Organisms New Diagnostic & Treatment Options for Fungal Infections New Living Donor Screening Recommendations New CMV Outcome Information

4 Exciting News that will Impact the Future of Transplant ID Passage of the HOPE Act in the US and HIV+ transplantation worldwide More new pathogens to worry about – Ebola – Ureaplasma urealyticum

5 Hepatitis C in Transplant

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10 New Living Donor Screening Guidelines

11 Desai R. Transplantation 2015;99:1989-1994. UK Transplant Registry data 1987-2007 for kidney, liver, heart, lung transplants 10 year post-transplant survival – CMV D-/R- recipients 73.6% significantly higher vs – All other recipients 66.1% (P < 0.0001) CMV status was NOT associated with increased risk of cancer Cardiovascular cause of death higher in CMV exposed recipients (18%) vs D-/R- (16%), P = 0.03

12 Stern, M. Transplantation 2014;98:1013-1018. HR 2.6 HR 1.6 HR 2.2 HR 5.8 A significant risk for graft rejection within 4 weeks after detection of CMV viremia was seen for all organ types Lung>Heart>Liver>Kidney CMV replication and seropositivity continue to play a role in graft rejection even in the modern era of transplantation Swiss Transplant Cohort Study 2008-2012 for kidney, liver, heart, lung transplants

13 Transplantation in the News

14 HOPE Act signed: November 21, 2013

15 HIV+ to HIV+ SOT: Preparing for HOPE

16 Reviewing the HIV+ Recipient Experience

17 Ebola Outbreak & SOT Kaul D. Amer J Transpl 2015;15:5-6.

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