1. Flow diagram of the systematic literature search indicating the inclusion and exclusion process of studies Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

2. Characteristics of included studies (n = 19) – Part I Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

3. Characteristics of included studies (n = 19) – Part II Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

4. Forest plot of retrieved studies evaluating preoperative statin use and the incidence of early all-cause mortality after cardiac surgery. OR, odds ratio; CI, 95% confidence interval Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

5. Incidence of clinical outcomes Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

6. Forest plot of retrieved studies evaluating preoperative statin use and the incidence of myocardial infarction after cardiac surgery. OR, odds ratio; CI, 95% confidence interval Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

7. Forest plot of retrieved studies evaluating preoperative statin use and the incidence of atrial fibrillation after cardiac surgery. OR, odds ratio; CI, 95% confidence interval Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

8. Forest plot of retrieved studies evaluating preoperative statin use and the incidence of stroke after cardiac surgery OR, odds ratio; CI, 95% confidence interval Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

9. Forest plot of retrieved studies evaluating preoperative statin use on the incidence of renal failure after cardiac surgery OR, odds ratio; CI, 95% confidence interval Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

10. Preoperative characteristics of patients Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59

11. Funnel plot with solid circles representing actual included studies with their respective study weight (%). The Trim-and-Fill method suggested that only one missing study was needed to achieve a symmetrical funnel plot, as indicated by the open circle. The solid vertical line represents the unadjusted odds ratio (OR) for short-term mortality, and the dotted line indicates the recalculated adjusted OR after allowing for publication bias. SE, standard error. Liakopoulos OJ, et al. Eur Heart J 2008;29:1548-59