Presentation is loading. Please wait.

Presentation is loading. Please wait.

CD4 T cells: fates, functions, and faults by Jinfang Zhu, and William E. Paul Blood Volume 112(5):1557-1569 September 1, 2008 ©2008 by American Society.

Similar presentations


Presentation on theme: "CD4 T cells: fates, functions, and faults by Jinfang Zhu, and William E. Paul Blood Volume 112(5):1557-1569 September 1, 2008 ©2008 by American Society."— Presentation transcript:

1 CD4 T cells: fates, functions, and faults by Jinfang Zhu, and William E. Paul Blood Volume 112(5):1557-1569 September 1, 2008 ©2008 by American Society of Hematology

2 Jinfang Zhu. Jinfang Zhu, and William E. Paul Blood 2008;112:1557-1569 ©2008 by American Society of Hematology

3 William E. Paul. Jinfang Zhu, and William E. Paul Blood 2008;112:1557-1569 ©2008 by American Society of Hematology

4 Summary of the 4 CD4 T helper cell fates: their functions, their unique products, their characteristic transcription factors, and cytokines critical for their fate determination. Jinfang Zhu, and William E. Paul Blood 2008;112:1557-1569 ©2008 by American Society of Hematology

5 T-cell differentiation involves instructive differentiation as well as selective expansion of differentiated cells. Jinfang Zhu, and William E. Paul Blood 2008;112:1557-1569 ©2008 by American Society of Hematology

6 Th2 differentiation driven by low concentration of peptide stimulation in vitro consists of an IL- 4–independent initiation phase and an IL-4–dependent amplification phase. Jinfang Zhu, and William E. Paul Blood 2008;112:1557-1569 ©2008 by American Society of Hematology

7 Cross regulation among the factors that are involved in Th1 and Th2 differentiation. Jinfang Zhu, and William E. Paul Blood 2008;112:1557-1569 ©2008 by American Society of Hematology

8 Positive and negative regulatory elements within Il4/Il13 loci and their binding to transcription factors. Jinfang Zhu, and William E. Paul Blood 2008;112:1557-1569 ©2008 by American Society of Hematology


Download ppt "CD4 T cells: fates, functions, and faults by Jinfang Zhu, and William E. Paul Blood Volume 112(5):1557-1569 September 1, 2008 ©2008 by American Society."

Similar presentations


Ads by Google