1. Module 5: Future 1 Canadian Bioinformatics Workshops www.bioinformatics.ca

2. Module 5: Future 2

3. 3 Summary Module 1: Introduction to Gene Lists Module 2: Gene Set Analysis Module 3: Inferring Regulatory Mechanisms Governing Sets of Genes Module 4: Pathway and Network Analysis

4. Module 5: Future 4 Round Table Discussion What does the future hold for Omics data analysis? What questions would you like to explore? What functions would you like to see in software? Discussion

5. Module 5: Future 5 Gene list analysis future Incorporating high-throughput functional data –New tools are being developed to compare gene lists against automatically updated databases of functional data to answer the questions like: “in which datasets are my genes best clustered” or “can I find more genes like these”? –In development: GeneMANIA: http://www.genemania.orghttp://www.genemania.org –Published: SPELL: http://imperio.princeton.edu:3000/yeast (yeast)http://imperio.princeton.edu:3000/yeast

6. Module 5: Future 6 Gene Regulation Future TF catalogs with functional annotations Allows users to explore candidate TFs to find relevance to their biological situation Coming Gene regulation annotations Greater community annotation efforts TF binding profiles Emerging PBM data and ChIP-Seq data will greatly expand CRM discovery Motif discovery for TF combinations Over-representation for ChIP “peaks”

7. Module 5: Future 7 Networks and Pathways Community curation Increasing network detail – more biologically relevant networks Network biomarkers Chemical genomics Requires: sophisticated software for curation and data integration

8. Module 5: Future 8 Visualizing Sub-gene Entities

9. Module 5: Future 9 Participant Ideas What do you want to be able to do? Given a gene list, what characteristics would you want to explore?