1. Table 1.1.1: Stock and Flow of Blood and Marrow Transplantation, 1987-2006 Year87888990919293949596 New transplant patients 86225122119253028 Deaths 116612951711 Lost to follow-up 0000000000 Alive at 31 st December 712282738576787100117 *1 patient in year transplant 2001 with no death date *Out of 1174 patients who were transplanted, there were 49 patients with early death before day 30 of transplant Year9798990001*0203040506 New transplant patients 33496294108114128139147124 Deaths15161531473051454025 Lost to follow-up0000000000 Alive at 31 st December 135168215278338422499592698797

2. Figure 1.1.1: Stock and Flow of Blood and Marrow Transplantation, 1987-2006 Number of patients (n) Year 0 100 200 300 400 500 600 700 800 New patients Alive at 31st Dec 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

3. Table 1.1.2: New Transplant Rate per million population (pmp), 1987-2006 Year1987198819891990199119921993199419951996 New transplant patients 86225122119253028 New transplant rate pmp 0010111111 Year1997199819992000200120022003200420052006 New transplant patients 33496294108114128139147124 New transplant rate pmp 2234455565

4. Figure 1.1.2: New Transplant Rate per million population (pmp), 1987-2006 New transplant rate pmp Year 0 1 2 3 4 5 6 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

5. Table 1.1.3: Distribution of Patients by Centre, 1987-2006 Year1987198819891990199119921993 No.% % % % % % % KLA00000000000000 KLP00000000000000 UKM00000000000000 SJA00001500000000 UMA00000000000015 UMP81006 2195510012100211001895 GMC00000000000000 LWE00000000000000 SJP00000000000000 ASH00000000000000 Hospital Ampang00000000000000 Others*00000000000000 TOTAL81006 221005 121002110019100 Year1994199519961997199819992000 No.% % % % % % % KLA00000000006101516 KLP41610331036927163319311617 UKM000000000023910 SJA0000000000581920 UMA416723621927153111181314 UMP1768134311391545183719312223 GMC00000000000000 LWE00000000000000 SJP00001400000000 ASH00000000000000 Hospital Ampang00000000000000 Others * 00000000000000 TOTAL25100301002810033100491006210094100

6. Year200120022003200420052006TOTAL No.% % % % % % % KLA20192825352741294430191520818 KLP18172018191522162114282321218 UKM121198 91410171297837 SJA17162018231821152316221815113 UMA2019161411910714109714612 UMP211920182016 12139181531427 GMC00000021213271 LWE00000064112291 SJP0011976412865353 ASH00000000001110 Hospital Ampang00000000007671 Others * 00000011000010 TOTAL1081001141001281001391001471001241001174100 Note: Distribution is according to transplant centre *Others include Royal Perth Hospital KLAHospital Kuala Lumpur, (Adult) KLPHospital Kuala Lumpur, Institute Paediatrics (Paed) UKMHospital Universiti Kebangsaan Malaysia SJASubang Jaya Medical Centre (Adult) UMAUniversity of Malaya Medical Centre (Adult) UMPUniversity of Malaya Medical Centre (Paed) GMCGleneagles Medical Centre, Penang LWELam Wah Ee Hospital, Penang SJPSubang Jaya Medical Centre (Paed) ASHAmpang Puteri Specialist Hospital Table 1.1.3: Distribution of Patients by Centre, 1987-2006

7. Figure 1.1.3: Distribution of Patients by Centre, 1987-2006

8. Number of patients (n) Year 0 10 20 30 40 50 60 70 80 90 100 110 120 130 140 150 GMC LWE SJP ASH Hospital Ampang others 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006

9. Table 1.2.1: Distribution of Patients by Gender, 1987-2006 Year19871988198919901991199219931994 GenderNo.% % % % % % % % Male 7884671255360758136213681664 Female 1132331045240542838632936 TOTAL 81006 221005 12100211001910025100 Year19951996199719981999200020012002 GenderNo.% % % % % % % % Male11371554185533673658545766616254 Female19631346154516332642404342395246 TOTAL301002810033100491006210094100108100114100 Year2003200420052006TOTAL GenderNo.% % % % % Male715583606947735966657 Female574556407853514150843 TOTAL1281001391001471001241001174100

10. Figure 1.2.1: Distribution of Patients by Gender, 1987-2006 Percentage of patients (%) Year 0 20 40 60 80 100 Male Female 1987198919911993199519971999200120032005

11. Table 1.2.2: Distribution of Patients by Ethnic Group, 1987-2006 Year1987198819891990199119921993 RaceNo.% % % % % % % Malay2254671359240433419316 Chinese56323383636075810481053 Indian1130000001841915 Bumiputra Sabah0000150000210316 Bumiputra Sarawak000000000000211 Others00000000001500 TOTAL81006 221005 121002110019100 Year1994199519961997199819992000 Race No. % % % % % % % Malay936723829927204131503335 Chinese1248144711392061244926424851 Indian0031062100484677 Bumiputra Sabah416130013000033 Bumiputra Sarawak000031100000000 Others005170039121233 TOTAL25100301002810033100491006210094100 Year200120022003200420052006TOTAL Race No. % % % % % % % Malay47443732463651375437544443837 Chinese48446557655163456746473855547 Indian87876596141097857 Bumiputra Sabah111143865376413 Bumiputra Sarawak111143755322252 Others332232112154303 TOTAL1081001141001281001391001471001241001174100

12. Figure 1.2.2: Distribution of Patients by Ethnic Group, 1987-2006 Percentage of patients (%) Year 0 10 20 30 40 50 60 70 80 90 100 Malay Chinese Indian Bumiputra Sabah Bumiputra Sarawak Others 1987198919911993199519971999200120032005

13. Table 1.2.3: Distribution of Patients by Age Group, 1987-2006 Year1987198819891990199119921993 Age groupNo.% % % % % % % 0-94504671777510010831571947 10-19450233523002176291053 20-3900000000000000 40-5900000000000000 ≥60 00000000000000 TOTAL81006 221005 121002110019100 Mean9786679 SD4333445 Median98866610 Minimum2212111 Maximum1510139 1417 Year1994199519961997199819992000 Age group No. % %. No. % % % % % 0-91144124013461958214328452729 10-19114413431243824163315242729 20-3931241331151512241219 20 40-5900130013007112021 ≥60 00000000000011 TOTAL25100301002810033100491006210094100 Mean11131112131723 SD79912101517 Median11 6101118 Minimum13115 months11 Maximum29413745395761

14. Year200120022003200420052006Total Age group No. % % % % % % % 0-923213026423326192920413338633 10-1928262522181441293121241929825 20-3940373632473752375135312531527 40-5916152320211618133524 1916614 ≥60 11000021114391 TOTAL1081001141001281001391001471001241001174100 Mean23 2223262420 SD16 15 161916 Median22 2320251816 Minimum1 month15 months112 months1 month Maximum64555270666970 *Age=date of transplant – date of birth Table 1.2.3: Distribution of Patients by Age Group, 1987-2006

15. Figure 1.2.3: Distribution of Patients by Age Group, 1987-2006

16. Table 1.2.4: Distribution of Patients by Primary Diagnosis, 1987-2006 Year1987198819891990199119921993 DiagnosisNo.% % % % % % % Acute leukaemia5634678362404018419632 Chronic leukaemia00001512018419211 Hypoplastic anaemia2250041800433524421 Erythrocytic disorders000015120181500 Lymphoma00000000000000 Solid tumors000000000031415 Myelodysplasia00000000000015 Haemoglobinopathy113233732120433419211 Multiple myeloma00000000000000 Others000015001800316 TOTAL81006 221005 121002110019100 Year1994199519961997199819992000 Diagnosis No. % % % % % % % Acute leukaemia832103313461133234728453739 Chronic leukaemia4165175186 7147111314 Hypoplastic anaemia52082741451548581112 Erythrocytic disorders00001400000000 Lymphoma000000265106 1920 Solid tumors14130013245822 Myelodysplasia28000000120011 Haemoglobinopathy5205175186 244677 Multiple myeloma00000000003511 Others001300265104633 TOTAL25100301002810033100491006210094100

17. Year200120022003200420052006TOTAL DiagnosisNo.% % % % % % % Acute leukaemia 48444842 3346335437383143637 Chronic leukaemia 181719171915221613911915813 Hypoplastic anaemia 7644541295314111089 Erythrocytic disorders 00112200000081 Lymphoma 23212018282235253423 1919517 Solid tumors 003322002132262 Myelodysplasia 444432644343303 Haemoglobinopathy 44871713961611 912010 Multiple myeloma 1144433285108343 Others 33336564117108595 TOTAL 1081001141001281001391001471001241001174100 Table 1.2.4: Distribution of Patients by Primary Diagnosis, 1987-2006

18. Table 1.3.1: Distribution of Patients by Graft Number, 1987-2006 Year1987198819891990199119921993 Graft numberNo.% % % % % % % 1 81006 198648097519901895 2 00002912032521015 3 00001500000000 TOTAL 81006 221005 121002110019100 Year1994199519961997199819992000 Graft numberNo.% % % % % % % 1 24962997281003194479661989197 2 14130013121233 3 00000013120000 TOTAL 25100301002810033100491006210094100 Year200120022003200420052006TOTAL Graft numberNo.% % % % % % % 1 103951139912598134981219811197110197 2 551132322222333 3 00000000001140 TOTAL 1081001141001281001371001231001141001138100

19. Figure 1.3.1: Distribution of Patients by Graft Number, 1987-2006 Percentage of patients (%) Year 0 20 40 60 80 100 Graft number 1 Graft number 2 Graft number 3 1987198919911993199519971999200120032005

20. Table 1.3.2: Distribution of Patients by Transplantation Type, 1987-2006 Year1987198819891990199119921993 Type of transplantNo.% % % % % % % Allogeneic + Syngeneic 81006 219551001210020951895 Autologous 00001500001515 TOTAL 81006 221005 121002110019100 Year1994199519961997199819992000 Type of transplantNo.% % % % % % % Allogeneic + Syngeneic 2496299726932782326544715660 Autologous 141327618173518293840 TOTAL 25100301002810033100491006210094100 Year200120022003200420052006TOTAL Type of transplantNo.% % % % % % % Allogeneic + Syngeneic 75697566846690659061836782570 Autologous 33313934443449355739413334930 TOTAL 1081001141001281001391001471001241001174100 Note: 6 patients with syngeneic type of transplant

21. Figure 1.3.2: Distribution of Patients by Transplantation Type, 1987-2006 Number of patients (n) Year 0 20 40 60 80 100 120 140 Allogeneic + Syngeneic Autologous 1987198919911993199519971999200120032005

22. Table 1.3.3: Type of transplant by Centre, 1987-2006 Type of transplantAllogeneic + SyngeneicAutologousTOTAL Centre No.% % % KLA106131022920818 KLP1842228821218 UKM506339837 SJA577942715113 UMA10212441314612 UMP2813433931427 GMC304171 LWE811091 SJP31441353 ASH100010 Hospital Ampang106271 Others*100010 TOTAL8251003491001174100 * Others include Royal Perth Hospital

23. Figure 1.3.3: Type of transplant by Centre, 1987-2006 Number of patients (n) Centre 0 20 40 60 80 100 120 140 160 180 200 220 240 260 280 Allogeneic + Syngeneic Autologous KLA KLP UKM SJA UMA UMP GMC LWE SJP ASH Ampang Others

24. Table 1.3.4: Source of Transplant, 1987-2006 Year19871988198919901991 Transplant sourceNo.% % % % % Marrow81006 221005 12100 PBSC / Marrow + PBSC0000000000 Cord blood / Marrow + cord0000000000 TOTAL81006 221005 12100 Year19921993199419951996 Transplant source No. % % % % % Marrow2110019100251003010028100 PBSC / Marrow + PBSC0000000000 Cord blood / Marrow + cord0000000000 TOTAL2110019100251003010028100 Year19971998199920002001 Transplant source No. % % % % % Marrow24732551376031333028 PBSC / Marrow + PBSC7212347233757617469 Cord blood / Marrow + cord2612236644 TOTAL33100491006210094100108100 Year20022003200420052006TOTAL Transplant source No. % % % % % % Marrow3127443430222416171446940 PBSC / Marrow + PBSC796979621007211679977865556 Cord blood / Marrow + cord44549675108504 TOTAL 1141001281001391001471001241001174100 PBSC = Peripheral Blood Stem Cells

25. Figure 1.3.4: Source of Transplant, 1987-2006 0 20 40 60 80 100 120 140 Marrow PBSC / Marrow+ PBSC Cord blood/ Marrow + cord 1987198919911993199519971999200120032005 Year Number of patients (n)

26. Table 1.3.5: Distribution of Patients by HLA Match, 1987-2006 Year19871988198919901991 HLA MatchNo.% % % % % Identical81006 211005 12100 1 AG0000000000 2 AG0000000000 ≥3 AG Disparate 0000000000 TOTAL81006 211005 12100 Year19921993199419951996 HLA MatchNo. % % % % % Identical201001810023962910026100 1 AG0000140000 2 AG0000000000 ≥3 AG Disparate 0000000000 TOTAL2010018100241002910026100 Year 19971998199920002001 HLA MatchNo. % % % % % Identical25933197409152936992 1 AG2700370045 2 AG0013124711 ≥3 AG Disparate 0000000011 TOTAL2710032100441005610075100 Year20022003200420052006TOTAL HLA Match No. % % % % % % Identical 7093799483928594779377994 1 AG 3434334445273 2 AG 2322441122182 ≥3 AG Disparate 000000000010 TOTAL 7510084100901009010083100825100 *excluding autologous

27. Table 1.3.6: Distribution of Patients by Allogeneic Donor Relationship, 1987-2006 Year19871988198919901991 Allogeneic Donor RelationshipNo.% % % % % Sibling81006 211005 1192 Unrelated 0000000000  Marrow 0000000000  PBSC / Marrow + PBSC 0000000000  Cord blood / Marrow + cord 0000000000 Others0000000018 TOTAL81006 211005 12100 Year19921993199419951996 Allogeneic Donor Relationship No. % % % % % Sibling201001810022922910026100 Unrelated0000000000  Marrow 0000000000  PBSC / Marrow + PBSC 0000000000  Cord blood / Marrow + cord 0000000000 Others0000280000 TOTAL2010018100241002910026100

28. Table 1.3.6: Distribution of Patients by Allogeneic Donor Relationship, 1987-2006 Year19971998199920002001 Allogeneic Donor Relationship No. % % % % % Sibling2696321004410055987296 Unrelated1400001234  Marrow 0000000000  PBSC / Marrow + PBSC 0000000000  Cord blood / Marrow + cord 110000001 3 Others0000000000 TOTAL2710032100441005610075100 Year20022003200420052006TOTAL Allogeneic Donor Relationship No. % % % % % % Sibling7195819681908291728778295 Unrelated4534910891113405  Marrow 0000111225218513  PBSC / Marrow + PBSC 000022211319410  Cord blood / Marrow + cord 41003 6675638733178 Others000000000030 TOTAL7510084100901009010083100825100 *excluding autologous, including syngeneic

29. Table 1.4.1: Distribution of Patients by Cause of Death, 1987-2006 Year19871988198919901991 Cause of deathNo.% % % % % Sepsis11000000001 GVHD00000011700 Underlying disease0000610058300 Haemorrhage001100000000 VOD0000000000 Organ Failure0000000000 Interstitial pneumonitis0000000000 Secondary malignancy0000000000 Others0000000000 Unknown0000000000 TOTAL11001 6 6 1 Year19921993199419951996 Cause of deathNo.% % % % % Sepsis150222120424655 GVHD00000042400 Underlying disease00667360318327 Haemorrhage001110021219 VOD0000001619 Organ Failure1500012021200 Interstitial pneumonitis0000000000 Secondary malignancy0000001600 Others0000000000 Unknown0000000000 TOTAL21009 5 1710011100

30. Table 1.4.1: Distribution of Patients by Cause of Death, 1987-2006 Year20022003200420052006TOTAL Cause of deathNo.% % % % % % Sepsis413142710229238327921 GVHD3105 920615283910 Underlying disease1963285523511641114420555 Haemorrhage0000242514164 VOD0000000031282 Organ Failure31024001300123 Interstitial pneumonitis001200250072 Secondary malignancy000000000010 Others000000250021 Unknown131212130041 TOTAL3010051100451003910025100373100 Note: 1 patient with missing cause of death reported Year19971998199920002001 Cause of deathNo.% % % % % Sepsis533166402649 GVHD00213172649 Underlying disease960116974722713370 Haemorrhage00160031024 VOD0000001324 Organ Failure1700170000 Interstitial pneumonitis0016001324 Secondary malignancy0000000000 Others0000000000 Unknown0000000000 TOTAL1510016100151003110047100

31. Figure 1.4.1: Patient Survival by Year of Transplant, 1987-2006 0.00 0.25 0.50 0.75 1.00 Cumulative survival 01234567891011121314151617181920 Duration in years Year 1987-1992Year 1993-1998 Year 1999-2006

32. Figure 1.4.2: Patient Survival by Gender, 1987-2006 0.00 0.25 0.50 0.75 1.00 Cumulative survival 0123456789 10 11121314151617181920 Duration in years MaleFemale

33. Figure 1.4.3: Patient Survival by Age Group, 1987-2006 0.00 0.25 0.50 0.75 1.00 Cumulative survival 01234567891011121314151617181920 Duration in years 0-9 years10-19 years 20-39 years≥40 years

34. Figure 1.4.4: Patient Survival by Type of Transplant, 1987-2006 0.00 0.25 0.50 0.75 1.00 Cumulative survival 01234567891011121314151617181920 Duration in years Allogeneic + SyngeneicAutologous

35. Figure 1.5.1: Disease-free Survival for Acute Myeloid Leukaemia, 1987-2006 (Allogeneic vs. Autologous) 0.00 0.25 0.50 0.75 1.00 Cumulative survival 01234567891011121314151617181920 Duration in years AllogeneicAutologous

36. Figure 1.5.2: Disease-free Survival for Acute Lymphoblastic Leukaemia, 1987-2006 (Allogeneic)

37. Figure 1.5.3: Disease-free Survival for Thalassaemia, 1987-2006 (Allogeneic)

38. Figure 1.5.4: Disease-free Survival for Non-Hodgkin’s Lymphoma, 1987-2006 (Allogeneic vs. Autologous) 0.00 0.25 0.50 0.75 1.00 Cumulative survival 01234 5 67891011121314151617181920 Duration in years AllogeneicAutologous

39. Figure 1.5.5: Disease-free Survival for Hodgkin’s Disease, 1987-2006 (Autologous)

40. Figure 1.5.6: Disease-free Survival for Chronic Myeloid Leukaemia, 1987-2006 (Allogeneic)

41. Figure 1.5.7: Disease-free Survival for Aplastic Anaemia, 1987-2006 (Allogeneic)

42. Figure 1.5.8: Disease-free Survival by Age Group for Acute Myeloid Leukaemia, 1987-2006 0.00 0.25 0.50 0.75 1.00 Cumulative survival 01234567891011121314151617181920 Duration in years PaediatricAdult Paediatric is defined as age  18 years and adult age >18 years

43. Figure 1.5.9: Disease-free Survival by Age Group for Acute Lymphoblastic Leukaemia, 1987-2006 0.00 0.25 0.50 0.75 1.00 Cumulative survival 01234567891011121314151617181920 Duration in years PaediatricAdult Paediatric is defined as age  18 years and adult age >18 years

44. Figure 1.5.10: Disease-free Survival by Age Group for Thalassaemia, 1987-2006 * No adult cases reported for Thalassaemia Paediatric is defined as age  18 years and adult age >18 years

45. Figure 1.5.11: Disease-free Survival by Age Group for Non-Hodgkin’s Lymphoma, 1987-2006 0.00 0.25 0.50 0.75 1.00 Cumulative survival 01234567891011121314151617181920 Duration in years PaediatricAdult Paediatric is defined as age  18 years and adult age >18 years

46. Figure 1.5.12: Disease-free Survival by Age Group for Hodgkin’s Disease, 1987-2006 0.00 0.25 0.50 0.75 1.00 Cumulative survival 01 2 34567891011121314151617181920 Duration in years PaediatricAdult Paediatric is defined as age  18 years and adult age >18 years

47. Figure 1.5.13: Disease-free Survival by Age Group for Chronic Myeloid Leukaemia, 1987-2006 0.00 0.25 0.50 0.75 1.00 Cumulative survival 01234567891011121314151617181920 Duration in years PaediatricAdult Paediatric is defined as age  18 years and adult age >18 years

48. Figure 1.5.14: Disease-free Survival by Age Group for Aplastic Anaemia, 1987-2006 0.00 0.25 0.50 0.75 1.00 Cumulative survival 01234567891011121314151617181920 Duration in years PaediatricAdult Paediatric is defined as age  18 years and adult age >18 years