2. © 2007 Peter B.L. Meijer The vOICe in Neuroscience 2007: Cross-modal plasticity & visual sounds Amedi et al., Nature Neuroscience, June 2007: Shape conveyed by visual-to-auditory sensory substitution activates the lateral occipital complex C LOtvV1 dx.doi.org/10.1038/nn1912 Late-blind expert user of The vOICe (Talairach normalized inflated cortex reconstruction) Percent signal change analysis of LOtv LOtv acts as a metamodal operator for shape

3. © 2007 Peter B.L. Meijer The vOICe in Neuroscience 2007: Cross-modal plasticity & visual sounds C Example spectrogram of a one-second sound generated by The vOICe. Amedi et al. show that in trained subjects such shape- preserving sounds ("soundscapes") activate part of LOtv, a brain region normally associated with shape processing by vision or touch. Since other types of sounds do not activate LOtv, this indicates that LOtv is mostly driven by shape information regardless of sensory input modality.The vOICe One-second soundscape of horse image