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Oesophagus. Oesophagus - squamous cell carcinoma Multiple LOH Amplification of CMYC, EGFR, CYCLIN D1, HST1… Overexpression of Cyclin D1 LOH at 3p2; LOH.

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Presentation on theme: "Oesophagus. Oesophagus - squamous cell carcinoma Multiple LOH Amplification of CMYC, EGFR, CYCLIN D1, HST1… Overexpression of Cyclin D1 LOH at 3p2; LOH."— Presentation transcript:

1 Oesophagus

2 Oesophagus - squamous cell carcinoma Multiple LOH Amplification of CMYC, EGFR, CYCLIN D1, HST1… Overexpression of Cyclin D1 LOH at 3p2; LOH at 9p31 LOH 3p14 (FHIT); LOH 17q25 (TOC) TP53 mutations Normal oesophagusOesophagitis Low-grade High-grade InvasiveSCC intraephitelial neoplasia

3 Oesophagus -adenocarcinoma, Barret‘s oesophagus

4

5 Stomach

6 Helicobacter pylori

7

8 Stomach - tumors

9 Carcinoma of stomach

10 Signet ring adenocarcinoma

11 Well differentiated adenocarcinoma

12 Intestine

13 Hirschprung‘s disease, ileum

14 Diverticulosis of large intestine

15 Ulceration during DIC

16 Abdominal typhus

17 Pseudomembranous colitis

18 Crohn‘s disease and ulcerous colitis

19

20 Crohn‘s disease

21

22 Crohn‘s disease, granuloma

23

24 Ulcerous colitis, dysplasia of glands

25 Intestine - tumors

26 Polyp of intestine

27

28

29 Adenocarcinoma of large intestine

30

31

32 Adenocarcinoma of large intestine PAS staining

33 Malignant lymphoma, CD20+


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