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TNIN Tecnologie Non Invasive per le Neuroscienze: Risonanza Magnetica Federico Giove

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Presentation on theme: "TNIN Tecnologie Non Invasive per le Neuroscienze: Risonanza Magnetica Federico Giove"— Presentation transcript:

1 TNIN Tecnologie Non Invasive per le Neuroscienze: Risonanza Magnetica Federico Giove federico.giove@roma1.infn.it

2 Mission To develop and exploit NMR approaches for the neurosciences Visual system, Neuroenergetics BOLD, MRS, multimodal approaches, neurocurrents Structural (pathologies)

3 BOLD

4 … OR NEURONAL CURRENTS?

5

6 FUNCTIONAL CONNECTIVITY MD Fox et al., PNAS 102:9673 (2005)

7 FUNCTIONAL CONNECTIVITY

8 GM atrophy HS MCIAD PCC AD HS MCI Hippocampus Functional connectivity HS MCIAD L -Hippocampus From PPC seed-region

9

10 NK Logothetis, Nature 453:869 (2008)

11 To complement BOLD findings 1H MRS drawbacks – Limited temporal resolution – Low spatial resolution CREATE STATIONARY DISENTAGLED CONDITIONS Add other modalities ASSESSING THE NEUROMETABOLIC COUPLING

12

13

14 VISUAL PERCEPTION V1 responds to invisible stimuli Activation of V1 per se is insufficient for awareness Viswanathan and Freeman, Nat Neurosci 10:1308 (2007)

15 fMRI RESULTS

16 MRS RESULTS

17

18 Marco Carnì Antonino M. Cassarà Mauro Di Nuzzo Michela Fratini Girolamo Garreffa, Marta Moraschi and Bruno Maraviglia (Fermi Center) Silvia Mangia (U Minnesota) Tommaso Gili (U Cardiff) Silvia Capuani, Giulia Di Pietro, Marco Palombo (U Sapienza)

19 EXTERNAL COLLABORATORS NEUROPHYSIOLOGY, NEUROSCIENCES: NK Logothetis, GE Hagberg, Y Murayama (MPI Tuebingen), Emiliano Macaluso (Santa Lucia IRCCS), Richard G Wise, Silvia De Santis (U Cardiff) CLINICAL RESEARCH M Bozzali, G Spalletta (Santa Lucia IRCCS) MODELLING: S Vannucci (Columbia), I Simpson (U Penn), A Carruthers (U Massachusetts), A De Martino, E Marinari (U Sapienza) PAST COLLABORATORS M Bianciardi, S Peca, G Giulietti, M Rebuzzi, P Porcari, F Di Salle


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