1. How is Asian/Chinese Skin different for photodamage?
Overview of Ultraviolet Effects:
Acute Damage
Chronic Damage
How is Asian/Chinese Skin
different for photodamage?

2. Inflammatory Mediators Inflammatory Mediators
UV Pathways to Skin Damage Damaging effects are 80% UVB/20% UVA
Direct DNA damage
UVB
ROS generation
UVA
Inflammatory Mediators
Inflammatory Mediators

3. Inflammatory Mediators Inflammatory Mediators
UV Pathways to Skin Damage Damaging effects are 80% UVB/20% UVA
Inflammatory Mediators
Inflammatory Mediators

4. UV Pathways to Skin Damage Damaging effects are 80% UVB/20% UVA
Enzymes
Matrix-degrading enzymes (MMP, etc)
Matrix-degrading enzymes (MMP, etc)
Enzymes

5. UV Pathways to Skin Damage Damaging effects are 80% UVB/20% UVA
Enzymes
Matrix-degrading enzymes (MMP, etc)
Matrix-degrading enzymes (MMP, etc)
Enzymes

6. Matrix-degrading enzymes (MMP, etc)
UV Pathways to Skin Damage Damaging effects are 80% UVB/20% UVA
Matrix-degrading enzymes (MMP, etc)
Enzymes

7. lead to chronic photodamage
Both UVA and UVB both
lead to chronic photodamage
UVB
UVA
Direct DNA damage
Immune suppression
Mutations and skin cancer
Reactive Oxygen Species
Inflammation
Pigmentation
Metalloproteineases
Collagen and elastin degradation
Sagging, wrinkles

8. Chinese women 14 – 20 years old

9. Chinese women 14 – 20 years old
Indian women 14 – 20 years old

10. Chinese women 65 - 75 years old

11. Indian women 65 - 75 years old

12. How is Asian/Chinese Skin different for photodamage?
Skin aging parameters start later than Caucasian1,2 with different patterns
Within Chinese population, skin aging parameters start earlier for higher UV exposure by approximately 10 years1
Korean wrinkle formation is highly correlated with sun exposure3
Pigment changes are different in Asian skin versus Caucasian with aging and photoaging1
Photoaging differences are not all explained by differences in pigmentation
Zhao, P. Wang C. Solar ultraviolet Radiation and Skin Damage: An epidemiological study among a Chinese popoulation. Archives of Environmental Health, 53:6, 1998.
Chung, J.H. Photoaging in Asians. Photodermatology, Photoimmunology & Photomedicine. 19:
Chung, J.H. Et al. Cutaneous Photodamage in Koreans. Archives of Dermatology 137:

13. Photodamage is not just about pigmentation and wrinkles
Photograph courtesy of Robert & Margaret Weiss, MD

14. Effects of UV on Photoaging: Conclusions
UV exposure induces photodamage and photoaging through several mechanisms
UVA can produce photoaging in the absence of UVB
In order to reduce photodamage, sunscreens must protect against both UVB and UVA
Photograph courtesy of Robert & Margaret Weiss, MD