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VFC Pediatric Vaccine Stockpile National Vaccine Advisory Committee October 23, 2007 Gregory S. Wallace, M.D., M.S., M.P.H. Chief, Vaccine Supply and Assurance.

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Presentation on theme: "VFC Pediatric Vaccine Stockpile National Vaccine Advisory Committee October 23, 2007 Gregory S. Wallace, M.D., M.S., M.P.H. Chief, Vaccine Supply and Assurance."— Presentation transcript:

1 VFC Pediatric Vaccine Stockpile National Vaccine Advisory Committee October 23, 2007 Gregory S. Wallace, M.D., M.S., M.P.H. Chief, Vaccine Supply and Assurance Branch Immunization Services Division National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention

2 History of Vaccine Stockpile 1983 – 317 Grant-funded Stockpile (MMR, DT, DTwP, OPV, IPV) 1993 – VFC Legislation requirement for “6-month stockpile” 2007 - > 20 million doses delivered

3 Current Stockpile Status (09/30/07)

4 VFC Stockpile Legislation Adequate Supply of Pediatric Vaccines to Meet Unanticipated Needs Negotiate for a 6-Month Supply Consider Potential for Outbreaks VFC Funded

5 Meet Unanticipated Needs VaccineDurationReasonResponse Td/TT11/00 – 6/02 (19 mos) GMP, leaving marketPriority for wound care DTaP3/01 – 7/02 (17 mos) GMP, preservative, leaving market Priorities based on provider supply MMR10/01 – 7/02 (10 mos) Manufacturing process updates Defer 2 nd doses if inadequate supply Varicella10/01 – 8/02 (11 mos) Manufacturing process updates Delay timing; prioritize if necessary PCV I8/01 – 5/03 (22 mos) Fill line problemsPriorities based on provider supply PCV II12/03 – 9/04 (10 mos) Fill line problems3-dose to 2-dose recommendation MCV4Summer ’05 & Summer ‘06 High DemandReinforce Recs to Defer 11-12 y.o.

6 Negotiate a 6-Month Supply Changing Market and Recommendations Storage and Rotation Public Health Need May Vary by Vaccine − # of manufacturers − adequacy of temporary schedules − delays vs. shortage/failure

7 Consider Potential for Outbreaks Goal Different from Production Interruptions Combination Vaccines May Complicate Outbreak Response Should Specific Outbreak Response Stockpile be Included for Some Vaccines Should Vaccines with Low Outbreak Potential be Excluded

8 VFC Funded May Limit Flexibility of Vaccine − Borrowing Back for Non-VFC Eligible Populations − Previous Uses were with 317 Funded Vaccine Fully Funded ~ Annual CDC Vaccine Purchase (> $2 billion) Minimize Risk of Loss vs. Maximize Utility

9 CDC Work Group Staffed by CDC Disease Experts, Program Experts, and Economists Charge to the Work Group: 1) Evaluate/Re-scope Stockpile Vaccine Target Quantities 2) Identify Criteria for Establishing Targets 3) Identify Criteria for Vaccine Draw Downs (emergency and non-emergency) 4) Identify Criteria for Updates (periodic and otherwise)

10 Proposed NVAC Role Sounding Board for Difficult Options Discuss Options and Approaches Present Recommendations for External Review Provide Updates When Major Changes are Considered

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