1. TM Current Political and Social Issues in the Prevention and Treatment of HIV/AIDS in Africa Cissy Kityo Mutuluuza MD, MSc Deputy Director Research & Clinical Joint Clinical Research Center

2. The HIV/AIDS burden The grim picture of Africa The World Sub-Saharan Africa Adults and children living with HIV/AIDS36.1 million 25.3 million Adults and children newly infected 20005.3 million 3.8 million Death so far due to AIDS22 million 15 million Orphans due to AIDS14 million 11 million

5. Main pillars of prevention Abstinence Be Faithful Condom use Voluntary Counselling and Testing STD Treatment PMTCT

6. Trends in the Ugandan HIV epidemic Rates %

7. HIV infection trends among pregnant women: Dakar  ²for trend: HIV1: p=0.6 HIV2: p=0.6 Prevalence in 1998:HIV1 0.5 (95% CI [0 – 3.0]) HIV2 0.2 (95% CI [0 – 0.7]) 0 1 2 3 4 5 1989199019911992199319941995199619971998 Prevalence (%) HIV1 HIV2

8. Lessons Possibility to prevent spread of the epidemic (Senegal) Possibility to contain and reduce (Uganda )

9. What is needed for success? Strong and committed political leadership Visible ownership by National leaders

10. Lag between the first reported AIDS case and initiation of a National AIDS Control Program 0 0.5 1 1.5 2 2.5 3 3.5 4 Uganda (1982) Rwanda (1983) Burundi (1983) Kenya (1984) Sudan (1986) Years

11. Political commitment What is needed for success? Multi-sectoral approach and community mobilization Broad awareness of HIV/AIDS in general population Efforts to reduce AIDS stigma Promote policy/legal changes to prevent discrimination National commitment to sex education of youth Availability of external assistance in financing and implementation

12. Prevention vs. Treatment Prevention - better than cure 25 million Africans already infected and need care Both treatment and prevention are priorities

13. Treatment as a preventive tool Mother to child transmission prevention General transmission Promotion of VCT Creation of better surveillance Stops some children from becoming orphans

14. Examples of treatment advantages for Africa - 1 WITH HAART WITHOUT HAART WITH HAART WITHOUT HAART Health Health Well, strong happy Sickly, weak less/no opportunistic infection Expensive to treat opportunistic infections Social economic Productive Too ill to work effectively Self sufficient Dependent and diminishing assets Family catered for Family suffering e.g no school fees Able to pay taxes etc Dependent on public services and Contribution to country soon to leave orphans

15. Prevention WITH HAARTWITHOUT HAART Incentive for VCT Testing - so what? Less likely to transmit virusMore likely to transmit virus Positive living more likely Positive living less likely and stake in the future future looks bleak Examples of treatment advantages for Africa - 2

16. AIDS patients and availability of ARVs

19. Response to the AIDS epidemic Prevention and Care programs reach fewer than 1 in 5 people who need them Proportion of women covered by PMTCT 5% Proportion who needed VCT and received it 7% Condom use in sex with a non co-habiting partner19% – Over 200 myths, misperceptions and fears that hinder access to use of condoms 60% of primary school students receive basic AIDS education Only 1 million people in low and middle income countries were receiving ART by June 2005

20. The Epidemic in Africa will continue to expand unless HIV Treatment and Prevention are scaled up dramatically

21. Scaling up towards universal access by 2010 Access to HIV prevention, care, treatment and support interventions Access is a function of availability, affordability and acceptability Coverage indicates the optimal availability and utilization – acceptability, equity and sustainability

23. Scaling up prevention and care Reducing HIV incidence will decrease demand for treatment Expanded access to treatment offers an opportunity for prevention efforts – Client initiated VCT – Provider initiated routine offer of HIV testing (STD, TB & MCH clinics, high prevalence settings) Visible treatment success should encourage more open dialogue about HIV Care and compassion messages will help reduce stigma

24. Challenges for achieving universal access - 1 Insufficient political will in many African countries for sustained evidence based programs Multi-sectoral responses are still not a reality in some countries Sustainable financing mechanisms (both national and international) are still not in place to meet costs of programs for those in need

25. Challenges for achieving universal access - 2 Under resourced and over stretched health systems Maintaining a reliable, affordable and adequate supply of quality medicines, condoms and diagnostics Financial, cultural and social barriers to access for populations most at risk, affected and in need

26. Vulnerable groups Girls and women Women are 30% more likely to be infected than men Prevention strategy of ABC not easy – Cultural norms, lack of social and economic power – Female condoms Costs involved in care prevent women and girls from accessing treatment and related diagnostics

28. Sex workers HIV prevalence is generally higher in sex workers than general population Prevention programs for sex workers highly cost-effective

30. Reducing vulnerability Initiatives that enhance economic and social development and empower women and girls contribute to effective AIDS responses e.g. Universal free education (Uganda, Kenya) – VCT for couples – Mining companies in S. Africa changing from single sex hostels to family housing for migrant workers

31. Stigma More willingness to seek VCT and avoid transmission Acceptance of AIDS victims and involvement in their care

32. Social economic status Cost of ART and related care is a major obstacle to accessing treatment – Decrease uptake – Decrease adherence – Treatment failure

33. Way forward Prevention, treatment and care for: – General population – High risk populations – High risk settings – Special groups

34. Recommendations Generate, improve and sustain national and international political commitment Countries in Africa need to scale up HIV prevention and treatment programs based on lessons learnt Build on existing structures and strengthen capacity for scaling up interventions

35. Recommendations Foster integration of HIV prevention and treatment Greater involvement of PLWAs especially those most marginalized Promotion and fulfillment of human rights including gender equality at the highest political level

36. Recommendations Health sector reform is required to ensure that the most efficient and effective models for health delivery are implemented (Primary Health Care) Provide treatment and care free of charge at point of service delivery

37. Conclusion To have an impact on the future course of the epidemic, successful treatment and prevention programmes must rapidly become comprehensive programs that reach all those at risk and obstacles to prevention must be swiftly addressed and overcome