1. KF Disease strikes Kerala state in India for the first time – Ethical Challenges
Dr. Jayakrishnan Thavody
Associate Professor
Department of Community Medicine
Government Medical College Kozhikode

2. Kayasanur Forest Disease (KFD)
A tick-borne viral disease
First reported in the Kyasanur forest of Karnataka state in India in 1957.
Transmission from monkeys to humans through tick bite.

3. KFD……
Symptoms - high grade fever, joint pain, bleeding from nose and gums.
Since 1957 KFD has claimed more than 500 lives in its state of origin – Karnataka.
But till 2015 KFD hadn’t entered the neighboring states

4. Tick bite scar on a the thigh of a forest guard

5. Kerala state
Kerala state in India has the maximum number of health care institutions and the best health quality indicators in India
highest Human Development Index (HDI)
the highest literacy rate (93.91%)
the highest life expectancy (77 years) and
the highest sex ratio (1,084 women per 1000 men)
This is often described as the “Kerala Model” of development

6. The tribal population within Kerala state is socioeconomically backward, with higher morbidity and mortality than general population.

7. KFD first appeared in Wayanad district of Kerala state in January 2015 as a focal outbreak following a monkey death.
Wayanad - A hilly district with a high population of forest dwelling tribals.
The KFD outbreak was restricted to tribals and forest department staff .
Ten deaths.
KFD first appeared in Wayanad district of Kerala state in January 2015 as a focal outbreak following a monkey death.

8. Ethical challenges

9. Access to Vaccine and effectiveness
No specific treatment for KFD and it is difficult to control the vector ticks
Hence vaccination of population at risk forms a significant KFD prevention strategy.
The vaccine is available
Though found effective in previous studies, a recent study had raised doubts about its effectiveness. Hence the Public health experts were now divided over its use in the current outbreak.
Is it ethical to administer the vaccine tribals in the wake of its doubtful efficacy to the vulnerable population – the forest dwelling.
Who should receive the limited supply of vaccine at first – the tribals or the forest staff who works in the area?
The vaccine is available already being used in the previously KFD affected areas

10. Treatment at public or private hospital?
The district where the outbreak happened does not have any government tertiary care hospital
The nearest government tertiary care hospital is 3.5 hours away.
There is a private medical school with good facilities in the area, but none of the patients would be able to afford the treatment costs.
So the challenge now was, from where could the seriously ill patients should get treatment – the distant public hospital which provides free care, or the nearby private hospital?

11. How these challenges were handled

12. Should the vaccine be used, and how?
Experts consensus to administer the available vaccine for now, and to recommend developing a more effective vaccine.
The vaccine was provided to all forest officials in the first stage. They were monitored for side effects. As no side effects were reported, it was decided to vaccinate all tribals in the area. The guidelines by government and international agencies in this regard helped in arriving at the decision.
Experts came to a consensus to administer the available vaccine for now, and to recommend making it more efficacious in the future.

14. Treatment at public or private hospital?
All the mild and moderate cases would continue to receive treatment from government facility.
After discussions, the private hospital agreed to treat the all the seriously ill KFD patients at their centre free of cost.

15. Key questions unanswered
In the face of the disease outbreak, was there enough evidence to justify providing the vaccine to this population?
Were the public health officials right to vaccinate the forest officials before the tribal people at risk?
What data should be collected on the vaccine’s effects as part of the vaccination program?
Would relying on private health institutions prevent the development of better facilities in the public sector in the long term?

16. Thank you