1. Update to IPC 10 December 2015 UNITAID's transformation

2. 1 2015-06-03 - Board presentation - v32.pptx Why are we changing our operating model? Goals and metrics for end of 2016 Speed Global alignment Sustainability Transparency A fast & agile process that aims to achieve grant development in 3 months Major partners engaged in dialogue on identifying new areas for intervention Successful projects scaled-up and/or transitioned Clear process and criteria for decision-making including VfM and risk

3. 2 2015-06-03 - Board presentation - v32.pptx Disease Global GoalsChallenges Opportunities for intervention Areas for interventions Potential interventions UNITAID projects HIV/AIDS TB Malaria What shortcomings require targeted competitive calls and / or direct request? What are targets the world agrees on? What are the needs, gaps, limitations? What are the opportunities for potential interventions? How does each project fit? What are the objectives, impact and value for money? Where can UNITAID make the greatest difference? UNITAID strategic investment framework

4. 3 2015-06-03 - Board presentation - v32.pptx Overview of the new operating model: 5 topics for focus Develop proposals Develop grant Implement & transition / close Signature & Disbursement Identify opportunities for intervention Call for proposals Selection of areas for intervention ii iii i Go-ahead of proposalsFinal approval Decision gate A BC D E Board involvement

5. 4 2015-06-03 - Board presentation - v32.pptx Identification of opportunities for intervention Develop proposals Develop grant Implement & transition / close Signature & Disbursement Identify opportunities for intervention Call for proposals Selection of areas for intervention ii iii i Go-ahead of proposalsFinal approval Decision gate A BC D A E Board involvement

6. 5 2015-06-03 - Board presentation - v32.pptx Identification of opportunities for intervention Range of 1:1 to formal meetings Partner dialogueUNITAID analyses Landscapes by disease & product type (Tx, Dx, Px) Market dynamics dashboard A

7. 6 2015-06-03 - Board presentation - v32.pptx Broad range of partners to engage with A Governments / MoHs Funding partners Technical partners Civil society: NGOs & communities Implementing partners Private sector

8. 7 2015-06-03 - Board presentation - v32.pptx Selection of areas for intervention Develop proposals Develop grant Implement & transition / close Signature & Disbursement Identify opportunities for intervention Call for proposals Selection of areas for intervention ii iii i Go-ahead of proposalsFinal approval Decision gate A BC D B E Board involvement

9. 8 2015-06-03 - Board presentation - v32.pptx What is an area for intervention? B Strategic area of investment to respond to specific challenges in achieving the Global goals for the three diseases Several projects can fit in a given area for intervention

10. 9 2015-06-03 - Board presentation - v32.pptx R&D IP issues Market entry Quality Availa- bility Price Op Research Delivery What is an area for intervention? Downstream HIV / AIDSTuberculosisMalaria Upstream PDPsBMGFIndustryAcademia...others...Grand Challenges Potential intervention for UNITAID Potential intervention for UNITAID Potential intervention for UNITAID B

11. 10 2015-06-03 - Board presentation - v32.pptx A 2-step process to select the areas Secretariat identifies opportunities for intervention Board approves areas for intervention Secretariat launches calls for proposals B

12. 11 2015-06-03 - Board presentation - v32.pptx Qualitative assessment B Global alignment Equity Fit with Global investments Timeline Fit with UNITAID mandate Fit with UNITAID portfolio Added value of UNITAID Public health rationale / expected change Public Health need

13. 12 2015-06-03 - Board presentation - v32.pptx Go-ahead decision Develop proposals Develop grant Implement & transition / close Signature & Disbursement Identify opportunities for intervention Call for proposals Selection of areas for intervention ii iiii Go-ahead of proposals Final approval Decision gate A BC D C E Board involvement

14. 13 2015-06-03 - Board presentation - v32.pptx Proposal selection process should be simple and efficient "Go-ahead" will be given by the Review Committee and sent to the Board for no objection Decision should be consensus-based Principles for the "Go-ahead" C

15. 14 2015-06-03 - Board presentation - v32.pptx Review Committee: How does it work? Secretariat PRC Partners input Strategic alignment Global alignment and sustainability Impact & value for money Technical approach & feasibility of the plan Organization experience & competitive advantage Risk assessment Budget quality C Criteria for review Collegial review

16. 15 2015-06-03 - Board presentation - v32.pptx Grant development and approval Develop proposals Develop grant Implement & transition / close Signature & Disbursement Identify opportunities for intervention Call for proposals Selection of areas for intervention iiiiii Go-ahead of proposalsFinal approval Decision gate A BC D D E Board involvement

17. 16 2015-06-03 - Board presentation - v32.pptx Final approval D Develop grant Implement & transition / close Signature & Disbursement iii Develop proposals Identify opportunities for intervention Call for proposals Selection of areas for intervention iii Go-ahead of proposals Decision gate iii Board gives final approval Secretariat submits grant for approval Develop grant PRC "light" review of technical soundness

18. 17 2015-06-03 - Board presentation - v32.pptx Recap: How we want to do things now Disease Global GoalsAnalyses Areas for interventions Potential interventions UNITAID projects HIV/AIDS TB Malaria Approved through the mechanism agreed Global goals set by the response and agreed upon by main stakeholders etc. Partner dialogue UNITAID analyses Calls for proposals Selection criteria: Public Health need Added value of UNITAID We are being more systematic, structured and transparent on our strategy

19. 18 2015-06-03 - Board presentation - v32.pptx Current interventions result from analyses UNITAID current interventions in these areas

20. 19 2015-06-03 - Board presentation - v32.pptx 3 areas that were recently approved to enhance our portfolio Recently identified as a top opportunity for intervention in short and long term Analysis shared with partners and countries

21. 20 2015-06-03 - Board presentation - v32.pptx Areas for intervention submitted to the Board – for decision Improve adult antiretroviral therapy in LMICs Enable of scale-up of PrEP & linkage to test Improve HCV diagnosis, especially for HIV/HCV co- infection 1 2 3

22. 21 2015-06-03 - Board presentation - v32.pptx Questions?