1. Rasvkoest pärinevate tüvirakkude ja trombotsüütide rikka plasma ja fibriini kasutamine regeneratiivses meditsiinis Üliõpilane: Roman Kornilov Juhendja: Tiia Tamme

2. Töö eesmärk Demonstreerida personaalse meditsiini ühte võimaliku meie tegevus valdkonda Trombotsüütide rikas plasma (platelet-rich plasma) s.t. kõrge kontsentratsiooniga trombotsüütide mass väheses plasmas, mille kasutamist alveolaarluu transplantaadile kirjeldas Marx 1998 aastal (Marx jt 1998). Sellel meetodil puuduvad äratõuke reaktsioonid. Seega on patsiendile hästi talutavad.

3. PRP ja PRF Trombotsüütide rikas plasma (PRP) ja trombotsüütide rikas fibriin (PRF). PRP – on tavaline trombotsüütarne mass ning ta koosneb vähekontsentratsioonilisest fibriini koest. PRF – on trombotsüütidest tehtud teise generatsiooni toode, millises ühinevad kõrge trombotsüütide ja fibriini kontsentratsioonid ühes lahuses.

4. Rasvkoest pärinevate mesenhümaalsete tüvirakkude isolatsioon.

5. Katsed

6. Tulemused

7. PRP kasutamine näo piirkonna noorendamises ja augmentatsioonis Frédéric Braccini, Jérome Paris and David M Dohan “Platelet-rich fibrin during facial lipostructure” The UK Journal of Medical Aesthetics and Anti-Ageing http://www.braccini.net/document/PDF/lipostructure_and_growths_factors.pdf

8. PRP kasutamine näo piirkonna noorendamises ja augmentatsioonis Frédéric Braccini, Jérome Paris and David M Dohan “Platelet-rich fibrin during facial lipostructure” The UK Journal of Medical Aesthetics and Anti-Ageing http://www.braccini.net/document/PDF/lipostructure_and_growths_factors.pdf

9. PRP kasutamine näo piirkonna noorendamises ja augmentatsioonis Frédéric Braccini, Jérome Paris and David M Dohan “Platelet-rich fibrin during facial lipostructure” The UK Journal of Medical Aesthetics and Anti-Ageing http://www.braccini.net/document/PDF/lipostructure_and_growths_factors.pdf

10. Kasvufaktorid (Grow Factors) B.I. Simon1,*, A.L. Zatcoff1, J.J.W. Kong1 and S.M. O’Connell Clinical and Histological Comparison of Extraction Socket Healing Following the Use of Autologous Platelet-Rich Fibrin Matrix (PRFM) to Ridge Preservation Procedures Employing Demineralized Freeze Dried Bone Allograft Material and Membrane The Open Dentistry Journal, 2009, 3, 92-99

11. Postoperatiivne parenemine hamba ekstraktsiooni järgselt. B.I. Simon1,*, A.L. Zatcoff1, J.J.W. Kong1 and S.M. O’Connell Clinical and Histological Comparison of Extraction Socket Healing Following the Use of Autologous Platelet-Rich Fibrin Matrix (PRFM) to Ridge Preservation Procedures Employing Demineralized Freeze Dried Bone Allograft Material and Membrane The Open Dentistry Journal, 2009, 3, 92-99

12. Postoperatiivne parenemine hamba ekstraktsiooni järgselt. B.I. Simon1,*, A.L. Zatcoff1, J.J.W. Kong1 and S.M. O’Connell Clinical and Histological Comparison of Extraction Socket Healing Following the Use of Autologous Platelet-Rich Fibrin Matrix (PRFM) to Ridge Preservation Procedures Employing Demineralized Freeze Dried Bone Allograft Material and Membrane The Open Dentistry Journal, 2009, 3, 92-99

13. Igeme retsessiooni ravi (Parodontoloogia) Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, Camargo P. Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial. Int J Periodontics Restorative Dent. 2012 Apr;32(2):e41-50.

14. Igeme retsessiooni ravi Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, Camargo P. Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial. Int J Periodontics Restorative Dent. 2012 Apr;32(2):e41-50.

15. Igeme retsessiooni ravi Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, Camargo P. Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial. Int J Periodontics Restorative Dent. 2012 Apr;32(2):e41-50.

16. Igeme retsessiooni ravi Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, Camargo P. Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial. Int J Periodontics Restorative Dent. 2012 Apr;32(2):e41-50.

17. Igeme retsessiooni ravi Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, Camargo P. Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial. Int J Periodontics Restorative Dent. 2012 Apr;32(2):e41-50.

18. Igeme retsessiooni ravi Jankovic S, Aleksic Z, Klokkevold P, Lekovic V, Dimitrijevic B, Kenney EB, Camargo P. Use of platelet-rich fibrin membrane following treatment of gingival recession: a randomized clinical trial. Int J Periodontics Restorative Dent. 2012 Apr;32(2):e41-50.

19. Igeme retsessiooni ravi Pavan Bajaj*, Nishanth S Rao*, Esha Agarwal*, A.R.Pradeep* ”Treatment of intrabony defect with platelet rick fibrin: Case report” Archives of Oral Sciences & Research 2011;1(2):90-94. http://www.aosr.co.in/files/7.pdf

20. Igeme retsessiooni ravi Tulemused Pavan Bajaj*, Nishanth S Rao*, Esha Agarwal*, A.R.Pradeep* ”Treatment of intrabony defect with platelet rick fibrin: Case report” Archives of Oral Sciences & Research 2011;1(2):90-94. http://www.aosr.co.in/files/7.pdf

21. Simultaan siinus-lifting ja implantatsioon, kasutades mini-implantaate ning PRF membraani mis olid ainsad autoloogilised transplantaat materialid: kuue-aastane kogemus Alain Simonpieri, DDS, Joseph Choukroun, MD, Marco Del Corso, DDS, Gilberto Sammartino, MD, PhD, and David M. Dohan Ehrenfest, DDS, MS, PhD Simultaneous Sinus-Lift and Implantation Using Microthreaded Implants and Leukocyte- and Platelet-Rich Fibrin as Sole Grafting Material: A Six-Year Experience IMPLANT DENTISTRY / VOLUME 20, NUMBER 1 2011

22. Simultaan siinus-lifting ja implantatsioon, kasutades mini-implantaate ning PRF membraani mis olid ainsad autoloogilised transplantaat materialid: kuue-aastane kogemus Alain Simonpieri, DDS, Joseph Choukroun, MD, Marco Del Corso, DDS, Gilberto Sammartino, MD, PhD, and David M. Dohan Ehrenfest, DDS, MS, PhD Simultaneous Sinus-Lift and Implantation Using Microthreaded Implants and Leukocyte- and Platelet-Rich Fibrin as Sole Grafting Material: A Six-Year Experience IMPLANT DENTISTRY / VOLUME 20, NUMBER 1 2011

23. Simultaan siinus-lifting ja implantatsioon, kasutades mini-implantaate ning PRF membraani mis olid ainsad autoloogilised transplantaat materialid: kuue-aastane kogemus Alain Simonpieri, DDS, Joseph Choukroun, MD, Marco Del Corso, DDS, Gilberto Sammartino, MD, PhD, and David M. Dohan Ehrenfest, DDS, MS, PhD Simultaneous Sinus-Lift and Implantation Using Microthreaded Implants and Leukocyte- and Platelet-Rich Fibrin as Sole Grafting Material: A Six-Year Experience IMPLANT DENTISTRY / VOLUME 20, NUMBER 1 2011

24. Platelet-Rich-Fibriini kasutamine hammaste pulbi revitalisatsioonis, avatud hamba apexi korral Vasundara Yayathi Shivashankar1, Dexton Antony Johns, S Vidyanath, M Ramesh Kumar “Platelet Rich Fibrin in the revitalization of tooth with necrotic pulp and open apex” Department of Conservative Dentistry and Endodontics, Government Dental College, Calicut, Kerala, India Department of Oral and Maxillofacial Pathology, Government Dental College, Calicut, Kerala, India Year : 2012 | Volume : 15 | Issue : 4

25. Platelet-Rich-Fibriini kasutamine hammaste pulbi revitalisatsioonis, avatud hamba apexi korral Vasundara Yayathi Shivashankar1, Dexton Antony Johns, S Vidyanath, M Ramesh Kumar “Platelet Rich Fibrin in the revitalization of tooth with necrotic pulp and open apex” Department of Conservative Dentistry and Endodontics, Government Dental College, Calicut, Kerala, India Department of Oral and Maxillofacial Pathology, Government Dental College, Calicut, Kerala, India Year : 2012 | Volume : 15 | Issue : 4

26. Photo: 9,000-Year-Old Drilled Teeth Are Work of Stone Age Dentists Archaeologists Find A 6,500 Year Old Dental Filling http://news.nationalgeographic.com/news/bigphotos/1948258.htmlhttp://www.forbes.com/sites/alexknapp/2012/09/22/arc haeologists-find-a-6500-year-old-dental-filling/

27. Tänan tähelepanu eest!