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? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration.

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Presentation on theme: "? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration."— Presentation transcript:

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2 ? Automated monitoring vs. single point testing ? Around the clock on-line monitoring ? Real-time blood analysis ? Superior sampling process ? Self-Calibration ? Improved safety and patient care Blutmonitor Multi-Sensor-Cartridge-System Click&Test Idee und Vorentwicklung im Rahmen eines Projektes des Ministerium für Wirtschaft und Mittelstand, Energie und Verkehr des Landes Nordrhein-Westfalen Produktentwicklung in Industriekooperation

3 ? Click&Test: T - Connector with adapter ? Click&Test:Single use disposable Multi-Sensor-Cartridge ? Click&Test: Reusable Console ? Click&Test: Monitor Display and Store Data Management Blutmonitor Multi-Sensor-Cartridge-System Click&Test The Click&Test System consists: Fast, safe, simple Superior patient management Cost effectiveness

4 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Schematic view of Click&Test

5 Blutmonitor Multi-Sensor-Cartridge-System Click&Test ? Operations with cardiopulmonary bypass ? Dialysis ? Hemofiltration ? High volume transfusions ? Organ transplantations ? postoperative care ? Quality control of culture medium ? Tissue engineering Clinical Applications

6 Blutmonitor Multi-Sensor-Cartridge-System Click&Test ? Heart surgery centers ? Transplantation centers ? Intensiv care units (ICU) ? Emergency departments ? Center of treatment of burnings ? Modern tissue culture laboratories Potential Customers

7 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Operationen mit der Herz-Lungen-Maschine (HLM) in den deutschen Herzzentren 2000

8 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Operationen mit der Herz-Lungen- Maschine (HLM) in Europa 1999 ? Deutschland ? Frankreich ? Großbritanien ? Italien ? Spanien ? Niederland ? Belgien ? Polen

9 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Containment Technology ? Silicon technology ? Membrane technology ? Microsystem technology

10 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Containment Technology Features ? Suitable for mass production ? Suitable for miniaturisation ? Substance-detecting sensor components securely anchored ? Simple housing and connection methods using through-contacted sensors ? Potential for development as multianalyte sensor and as sensor array

11 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Containment Technology Cross-sectional view of a containment sensor Cross-sectional view of a flow through chip flow channel containment glass silicon chip Encapsulation silicon chipactive membrane active surface of the sensor gold electrode Potentiometric ion sensors Amperometric enzyme sensors Amperometric microbial sensors

12 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Potentiometric ion - selective sensors

13 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Potentiometric ion - selective sensor (a) SEM micrograph showing a containment element with patterned silver electrode for use in potentiometric sensors (b) SEM micrograph showing the membrane surface of the potassium sensor

14 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Containment sensors for medical diagnostics Analysis of blood electrolytes ? Potassium K + ? Calcium iCa 2+ ? pH ? Sodium Na + ? Hematocrit ? SaO 2 ? Hemoglobin

15 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Containment sensors for medical diagnostics

16 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Containment sensors for medical diagnostics

17 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Containment sensors for medical diagnostics

18 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Containment sensors for medical diagnostics

19 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Containment sensors for medical diagnostics

20 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Containment sensors for medical diagnostics

21 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Containment sensors for medical diagnostics

22 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Segment of the potential-time plot of a three point calibration of a long-term experiment for potassium, sodium, calcium, and pH taken simultaneously in two flow-through cells coupled in series Measurements and results

23 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Measurements and results Reproducibility and stability of the potential difference between two standard calibration solutions ( U = U [cal.3] - U[cal.1]) during 125h

24 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Preclinical measurements and results Potential-time plot of potassium concentration as measured during an extracorporal animal blood circulation run

25 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Preclinical measurements and results Potential-time plot of simultaneous on-line monitoring by a sensor chip integrated with three different sensor elements used in whole blood measurement

26 Blutmonitor Multi-Sensor-Cartridge-System Click&Test Preclinical measurements and results Correlation of K + measurements of 18 human whole blood samples as obtained by our on-line monitoring system and by the clinical laboratory blood gas/electrolyte analyzer RADIOMETER ABL 625


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