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Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas.

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Presentation on theme: "Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas."— Presentation transcript:

1 Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas Proisy, Swee Y. Sharp, Kathy Boxall, Stephen Connelly, S. Mark Roe, Chrisostomos Prodromou, Alexandra M.Z. Slawin, Laurence H. Pearl, Paul Workman, Christopher J. Moody Chemistry & Biology Volume 13, Issue 11, Pages 1203-1215 (November 2006) DOI: 10.1016/j.chembiol.2006.09.015 Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

2 Figure 1 Chemistry & Biology 2006 13, 1203-1215DOI: (10.1016/j.chembiol.2006.09.015) Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

3 Figure 2 Chemistry & Biology 2006 13, 1203-1215DOI: (10.1016/j.chembiol.2006.09.015) Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

4 Figure 3 Chemistry & Biology 2006 13, 1203-1215DOI: (10.1016/j.chembiol.2006.09.015) Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

5 Figure 4 Chemistry & Biology 2006 13, 1203-1215DOI: (10.1016/j.chembiol.2006.09.015) Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

6 Figure 5 Chemistry & Biology 2006 13, 1203-1215DOI: (10.1016/j.chembiol.2006.09.015) Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

7 Figure 6 Chemistry & Biology 2006 13, 1203-1215DOI: (10.1016/j.chembiol.2006.09.015) Copyright © 2006 Elsevier Ltd Terms and Conditions Terms and Conditions

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