1. Transient Soft-Tissue Edema Associated with Implantation of Increasing Doses of rhBMP-2 on an Absorbable Collagen Sponge in an Ectopic Rat Model by Hyun W. Bae, K. Brandon Strenge, Nomaan Ashraf, Jeffrey M. Badura, Steven M. Peckham, and William F. McKay J Bone Joint Surg Am Volume 94(20):1845-1852 October 17, 2012 ©2012 by The Journal of Bone and Joint Surgery, Inc.

2. Treatment rotation scheme. Hyun W. Bae et al. J Bone Joint Surg Am 2012;94:1845- 1852 ©2012 by The Journal of Bone and Joint Surgery, Inc.

3. Average edema volumes as determined with quantitative MRI in Part I. Hyun W. Bae et al. J Bone Joint Surg Am 2012;94:1845-1852 ©2012 by The Journal of Bone and Joint Surgery, Inc.

4. Sample MRIs from Part I demonstrating the increased signal intensity observed at the sites of the implants at two days. Hyun W. Bae et al. J Bone Joint Surg Am 2012;94:1845-1852 ©2012 by The Journal of Bone and Joint Surgery, Inc.

5. Sample T2-weighted MRIs from Part I demonstrating the increased signal intensity observed at the sites of the implants at seven days. Hyun W. Bae et al. J Bone Joint Surg Am 2012;94:1845-1852 ©2012 by The Journal of Bone and Joint Surgery, Inc.

6. Histological images (hematoxylin and eosin, ×40) obtained two days after treatment with the 0- μg (Fig. 5-A), 30-μg (Fig. 5-B), 129-μg (Fig. 5-C), and 450-μg (Fig. 5-D) doses of rhBMP-2 on the ACS. Note the residual ACS carrier (brown arrows) with increased... Hyun W. Bae et al. J Bone Joint Surg Am 2012;94:1845- 1852 ©2012 by The Journal of Bone and Joint Surgery, Inc.

7. Histological images (hematoxylin and eosin, ×200) obtained seven days after treatment with the 0-μg (Fig. 6-A), 30-μg (Fig. 6-B), 129-μg (Fig. 6-C), and 450-μg (Fig. 6-D) doses of rhBMP-2 on the ACS. Note the residual ACS carrier (brown arrow) and the minim... Hyun W. Bae et al. J Bone Joint Surg Am 2012;94:1845- 1852 ©2012 by The Journal of Bone and Joint Surgery, Inc.

8. Average edema volumes as determined with quantitative MRI in Part II. Hyun W. Bae et al. J Bone Joint Surg Am 2012;94:1845- 1852 ©2012 by The Journal of Bone and Joint Surgery, Inc.

9. Sample MRIs from Part II. The image on the left demonstrates the increased signal intensity observed in the groups containing rhBMP-2 on the ACS carrier (rhBMP-2/ACS Implants). Hyun W. Bae et al. J Bone Joint Surg Am 2012;94:1845-1852 ©2012 by The Journal of Bone and Joint Surgery, Inc.