1. A gift from Manitou in addition to potatoes and maize
Christopher Columbus, 1492
His sailors brougt it home, they were arrested
Persectuted by the Holy Inquisition, too

2. Nicotinia genus, Solanaceae family
Relative of potato, tomato, paprika, belladonna...
Nicotin – alkaloid (toxins, drugs)
Isolated by Vaquelin
Jean Nicot was the ambassador of France Lisbon, XVIth century

3. King James, 1604 and many others
A custom loathsome to the eye, hateful to the nose, harmful to the brain, dangerous to the lung, and the black stinking fume thereof, nearest resembling the horribly Stygian smoke of the pit that is bottomless.
BUT
taxes, profit, economy
and also positive health effects

4. Nicotine In the brain nicotine binds to the acetylcholine receptors,
stimulates the secretion of the dopamine and affects the function of the mesolimbic system.
Activates both the sympathetic and parasympathetic nervous system.
Relaxation in stressful situations and stimulating effect in tranquil state.

5. N
CH3 N

6. Smoking of nicotine
Very effective delivery system (in 10 seconds reaches the brain)
0,2 mg is already effective (1 cigarette contains 8 – 9 mg; 0,3 – 3 mg gets in the body)
Half life about 40 minutes
NICOTINE IS ADDICTIVE !!!

7. Nicotine is addictive but not very dangerous
70 – 90 % of smokers are unable to quit (not a moral weakness)
Development of tolerance (more and more)
Withdrawal symptoms

8. Nicotine is addictive but not very dangerous
Comparison with other addicitons:
Alcohol: moderate consumption is not harmful and does not lead to addiction. Alcoholism is extremely harmful to both the mental and physical health.
Drugs: Consumption is dangerous to mental health, high probablility od addiction.
Nicotine: Addictive but not harmful to personality, the health damage is NOT from nicotine

9. Smoke and tar are dangerous
The burning of cigarette is a complex physico-chemical process.
Average temperature of the tip is 900 oC
The main product is smoke containing the nicotine and a high number of organic and inorganic substances.
After condensation of the smoke the remaining substance is a dark stinking tar.
One cigarette produces about 2 litres of smoke which contains about 30 mg of tar

10. Examples of harmful substances in smoke and tar
Condensed aromatic compounds (powerful carcinogens - benzpyrene, benzanthracene, aniline)
Nitrocomponds (mutagens, carcinogens)
Small organic molecules (formaldehyde, ammonia, cyanides)
Toxic metals (Cd, Ni, Co)
Reactive oxygen compounds (1014 in one puff)
Carbon monoxide (inactivated Hb)

11. Reactive oxygen compounds
High concentration is smoke, effect amplified by metal catalysts
Conserved in tar
Added by activated phagocytes of respiratory organs (inflammation)
Inactivation of antioxidants

12. CARDIOVASCULAR DISEASE
Ischemic heart disease, myocardial infarction
Peripheral vascular disease
Stroke
LUNG DISEASE
Lung cancer
Chronic obstructive bronchitis
Emphysema

13. GASTROINTESTINAL DISEASE
Cancer of oral cavity, larynx, esophagus
Peptic ulcer
Esophageal reflux disease
Cancer of pancreas
UROGENITAL DISEASE
Cancer of bladder

14. SENSES
Age related macular degeneration
COMPLICATIONS OF PREGNANCY
Infants small for gestational age
Stillbirth
High perinatal mortality
Abnormalities of placenta

15. What can we do ? QUIT DO NOT BEGIN USE FILTERS SMOKE “LIGHTS”
Elctronicc cigarette?
RIGHT
RIGHT, BUT
WRONG