1. Classification of Tissues Relationship of Cell Specialization to Tissue Function Characteristics Distinguishing Tissue Types Functions of Major Tissue Types Epithelial Tissues: Introduction

2. Relationship of Cells to Tissues Cells are specialized to perform specific functions (secretion, support, contraction, neurotransmission, energy storage, etc.) Groups of cells form tissues with specific functions. Question: how many types of tissues are there? Answer: four -epithelial tissue -connective tissue -muscle tissue -nervous tissue (epithelial and connective tissues are the most diverse) Groups of tissues form organs with specific functions

3. Features which differ between tissue types The proportion of cells in the tissue The types of cells that make up the tissue The proportion of extracellular matrix in the tissue The amount of cell to cell contact The rate of cell division (mitosis)

4. Rate of cell division In general, the mitotic rate is inversely related to the life span of the cell. epithelial tissue: high mitotic rate connective tissue: intermediate muscle tissue: lower nervous tissue:lowest mitotic rate Life Span Mitotic Rate

5. MINUTE QUIZ n Which tissue has the lowest mitotic rate? A. Muscle B. Epithelial C. Nervous D. Connective

6. Functions of Major Tissue Types Epithelial: permeability (absorption, filtration), secretion, protection

7. Functions of Major Tissue Types Connective: structural support, energy storage, blood cell formation

8. Functions of Major Tissue Types Muscle: movement, support of body, protection, heat generation

9. Functions of Major Tissue Types Nervous: sensation and response to environment, regulation of body systems (cardiac, respiratory, endocrine, etc.)

10. The function of an organ is determined by the types of tissues which form it.

11. Epithelial Tissues Recall that epithelial tissues play important functional roles in: )protection (skin, lining of organs) selective permeability (absorption, filtration) secretion (glands)

12. Characteristics of Epithelial Tissue Consists almost entirely of cells Covers body and organ surfaces, and forms glands Has one free surface (luminal) and basement membrane Has specialized cell contacts Is avascular (no direct blood supply) Cells retain the ability to undergo mitosis

13. Classification of Epithelial Cells Simple vs stratified

14. stratified

15. Lateral and basilar surfaces of epithelia cells have connections which do three things: Types of Epithelial Cell Connections 1) bind the cells together, 2) form a permeability barrier, and 3) provide a mechanism of cell-to-cell communication

16. Types of Epithelial Cell Connections Desmosomes: Disk-shaped structure containing glycoproteins and intermediate filaments that bind cells together strongly. Tight junctions: Form a permeability barrier through fusion of cell membranes (zonula occludens)and adhesive glycoprotein (zonula adherens). Permeability barrier to water. Gap Junctions: Composed of protein channels connecting the lateral surfaces of two neighboring cells. Allow cell-to-cell communication.

17. Next Lecture... Water, Solutions, and Membranes