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Purinsynthese. O OH HO C O OO P P OOOO PO 5-Phosphoribosyl-1-pyrophosphat (PRPP) H2NH2N COO - O CCH 2 C H + NH 3 GlutamatGlutamin COO -- OOCCH 2 C H +

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Presentation on theme: "Purinsynthese. O OH HO C O OO P P OOOO PO 5-Phosphoribosyl-1-pyrophosphat (PRPP) H2NH2N COO - O CCH 2 C H + NH 3 GlutamatGlutamin COO -- OOCCH 2 C H +"— Presentation transcript:

1 Purinsynthese

2 O OH HO C O OO P P OOOO PO 5-Phosphoribosyl-1-pyrophosphat (PRPP) H2NH2N COO - O CCH 2 C H + NH 3 GlutamatGlutamin COO -- OOCCH 2 C H + NH 3 O OH HO C PO NH 2 O O P OO O P OO O 5-Phosphoribosyl-1-amin W. Storch D. Doenecke

3 Glutamat O OH HO C PO NH 2 COO - H C H + NH 3 Phosphoribosylamin Glycin ATP N H + NH 3 C O CH 2 OOH P OO ADP C O H THF C O H NH H2NH2N COO - O CCH 2 C H + NH 3 Glutamin C O CH 2 N H COO -- OOCCH 2 C H + NH 3

4 N NH 2 N C CH HC N NH 2 N C C HC C O O OOH P OO N H N NH C CH 2 C O H C CH H ADP ATP C O O HO N HN N C CH HC C O O O OH HO C PO ATP OOH P OO ADP Bicarbonat C H3NH3N C CH 2 C H O HO O O + Aspartat N NH 2 N C C HC C O C HN C CH 2 C H O HO O O C C CH C H O HO O O N NH 2 N C C HC C O NH 2 Fumarat ATP OOH P OO ADP THF N N N C C HC C O NH C H H2OH2O Inosinat (IMP) C O THF H N N N C C HC C O NH 2 H C O H

5 Adenylat (AMP) C C CH C H O HO O O N N N C C HC C N C H N N N C C C O NH C H GDP O OH HO C PO GTP C H3NH3N C CH 2 C H O HO O O + Aspartat Fumarat Inosinat (IMP) C HN C CH 2 C H O HO O O H NH 2 O P OO O

6 NADH+H + NAD N N N C C HC C O NH C H AMP O OH HO C PO ATP Inosinat (IMP) H2OH2O N HN N C C HC C O NH C O H2NH2N COO - O CCH 2 C H + NH 3 Glutamin COO -- OOCCH 2 C H + NH 3 Glutamat N N C C HC C O HN N C H Guanylat (GMP)


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