1. Single crystal X-ray diffraction
Dr Georgina Rosair
Lab: G.06/7 Ground floor below crush area

2. Power of crystallography
Crystals <1mm long
Complete 3D structure

3. Crystal growing tips
PURIFY your compound as much as is practically possible.
FILTER the solution you will grow the crystals from
TEST THE CRYSTALS are they the RIGHT compound
Remove a few crystals to see if they lose solvent and examine them by infrared, nmr etc.
Grow the crystals SLOWLY and with the MINIMUM of vibration - a fridge is a good place.
PERSEVERE - you may need to try several methods

4. Crystal growing methods
Solvent diffusion
Dissolve your compound in a solvent in which it is soluble and layer slowly on top a second solvent in which it is almost insoluble.
The two solvents must be miscible. CH2Cl2/hexane is a common combination.
Nmr samples have been used successfully

6. When you have crystals, what do you do?
Completed forms into the pocket on the X-ray notice board outside G.07
Contact number – lab phone no & HW
LABELLED Samples in the analytical services fridge/freezer in the 200mHz NMR room

8. X-ray crystallography and your research
Structure solution and refinement
Access to databases
Pictures and tables for reports and papers
X-seed software you can download and use on your laptop
Advice and training from me

9. Crystallographic results