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Published byBarbra Carpenter Modified over 8 years ago
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1 Mechanics of the Unusual Basilar Membrane in Gerbil Santosh Kapuria, IIT Delhi Charles Steele, Stanford Sunil Puria, Stanford
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2 Microstructure of BM Detailed anatomy Guinea pig: S Iurato (1962) Cat: LM Cabazudo (1978) Gerbil: Schweitzer L, Lutz C, Hobbs M, Weaver SP (1996) Point load measurements Human: Békésy (1960) Guinea pig: Gummer WA, Johnstone BM, Armstrong NJ (1981) Miller, C (1985) Gerbil: Olson EE, Mountain DC (1994) Naidu, RC, Mountain DC (1998) Emadi G, Richter CP, Dallos P (2004)
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3 Iurato 1962,gp
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4 I- Beam
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Beam with constraints 5
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6 Gerbil organ of Corti Arc of BM Edge, et al. (1998)
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7 Gerbil OC (Corrales, 2006) 7
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8 Beam model for BM
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9 Arch model
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10 Buckling of arch
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Olson and Mountain 1994 11
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Emadi et al. 2004 12
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13 Emadi, et al. (2004)
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Point load on arch 14
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15 Pressure loading without Pillar stiffness
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16 Frequency map
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18 Fast4 model of OC
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Gerbil 2.75 mm, 1 kHz, wavelength = 10 mm 19
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Gerbil 2.75, with pressure amplitudes 20
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Gerbil at 2.75 mm, add axial flow amplitudes 21
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Gerbil at 2.75 mm, add axial flow amplitudes with viscosity 22
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23 Gerbil at BF, add axial viscosity
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24 Acknowledgement q Fulbright Fellowship to SK q NIH RO1 DC007910
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25 Close up, showing cilia and tip links
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2607/07/2011 Lubrication theory HS TM IHC tip of cilium gapTM gapHS qHS qTM pressL1 pressIS Fluid displacement FD FD gapHS gapTM = – pressL1– pressIS qHS qTM perm * d/dt Edge, et al. (1998)
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