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CD11b is a therapy resistance– and minimal residual disease–specific marker in precursor B-cell acute lymphoblastic leukemia by Peter Rhein, Rita Mitlohner,

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Presentation on theme: "CD11b is a therapy resistance– and minimal residual disease–specific marker in precursor B-cell acute lymphoblastic leukemia by Peter Rhein, Rita Mitlohner,"— Presentation transcript:

1 CD11b is a therapy resistance– and minimal residual disease–specific marker in precursor B-cell acute lymphoblastic leukemia by Peter Rhein, Rita Mitlohner, Giuseppe Basso, Giuseppe Gaipa, Michael N. Dworzak, Renate Kirschner-Schwabe, Christian Hagemeier, Martin Stanulla, Martin Schrappe, Wolf-Dieter Ludwig, Leonid Karawajew, and Richard Ratei Blood Volume 115(18):3763-3771 May 6, 2010 ©2010 by American Society of Hematology

2 Correlation of CD11b mRNA at diagnosis with percentage of blasts at day 8. Peter Rhein et al. Blood 2010;115:3763-3771 ©2010 by American Society of Hematology

3 ROC curve analysis of discrimination of FCM-MRD remission status (FCM positive vs negative) and BFM risk stratification (high vs standard) according to CD11b expression levels at diagnosis. Peter Rhein et al. Blood 2010;115:3763-3771 ©2010 by American Society of Hematology

4 CD11b protein expression is consistently increased in MRD cells. Peter Rhein et al. Blood 2010;115:3763-3771 ©2010 by American Society of Hematology

5 CD11b expression in ALL blasts under therapy: modulation vs selection. Peter Rhein et al. Blood 2010;115:3763-3771 ©2010 by American Society of Hematology

6 CD11b positivity improves discrimination between ALL and normal mature and precursor B cells. Peter Rhein et al. Blood 2010;115:3763-3771 ©2010 by American Society of Hematology

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