1. Integrating a Molecular Signature of Intrinsic Radiosensitivity into the Classification of Breast Cancer J. F. Torres-Roca, W. J. Fulp, A. O. Naghavi, N. Servant, M. Bollet, M. J. van de Vijver, E. E. Harris, S. A. Eschrich Moffitt Cancer Center and Research Institute, Tampa FL Institut Curie, Paris, France Netherlands Cancer Institute, Amsterdam, Netherlands East Carolina University, Greenville, NC

2. Regulatory Networks Scale Torres-Roca J, et al. (2005) Cancer Res 65:7169- 76 Eschrich SA et-al (2009) IJROBP 75:489-96 Eschrich S et al (2009) IJROBP;75:497-505 Eschrich SA eta al (2012) Clin Can Res 18:5134- 43 Torres-Roca JF (2012) Per Med 9:547-55 Identification of Ten Genes in the Molecular Signature Confidential

3. RSI Predicts Local Recurrence in ER- and Triple Negative Patients

4. MVA: RSI Predicts Local Recurrence in ER- Patients

5. MVA: Combined RSI/Molecular Subtype Predicts Local Recurrence

6. Intrinsic Radiosensitivity into the Classification of Breast Cancer Conclusions – RSI in combination with molecular phenotype identifies novel sub-populations with a high risk of local recurrence after BCT