1. Familial Hypercholesterolaemia - My Family History By John Moore as told to Devi Nair

2. Family History - JM JM TC 12.0 (mmol/L) Index Case 1929

3. Family History - JM JM TC 12.0 (mmol/L) Index Case 1929 First degree relatives 1 in 2 chance Second degree relatives 1 in 4 chance

4. Family History - parents II I JM TC 12.0 (mmol/L) Index Case F M 1929 First degree relatives 1 in 2 chance Second degree relatives 1 in 4 chance †57y†42y

5. Family History - siblings II I JM TC 12.0 (mmol/L) MI age Index Case f m 55 y First degree relatives 1 in 2 chance Second degree relatives 1 in 4 chance †57y†42y MI age 50 MI High cholesterol pat Old age MI age 50 angina

6. Family History - children II I JM TC 12.0 (mmol/L) MI age Index Case f 55 y †57y†42y MI age 50 MI High cholesterol pat Old age anna MI age 50 angina III 1959 4.3/2.4 1954 On RX 1953 on RX 1951 On Rx NT

7. Family History – grand children II I JM TC 12.0 (mmol/L) MI age Index Case f m 55 y †57y†42y MI age 50 MI High cholesterol pat Old age anna MI age 50 angina ?tested iv Rx 1992 1990 TC 6 LDL 3.8 6.3 /4.3 1987 1985 1983 2,6/0.43 3.1/1.5 5.1/2.9 1989 3.8/2.NT

8. Family History – grand children II I JM TC 12.0 (mmol/L) MI age Index Case f m 55 y †57y†42y MI age 50 MI High cholesterol pat Old age anna MI age 50 angina ?tested iv Rx 1992 1990 TC 6 LDL 3.8 6.3 /4.3 1987 1985 1983 2,6/0.43 3.1/1.5 5.1/2.9 1989 3.8/2.NT