1. Three Key Neurotransmitter Systems of Antidepressants
Norepinephrine
Dopamine
Serotonine

2. NOREPINEPHRINE RECEPTORS
presynaptic alpha 2 autoreceptor
postsynaptic alpha 2 receptor
alpha 1 receptor
postsynaptic beta 1 receptor
5-19
Stahl S M, Essential Psychopharmacology (2000)

3. presynaptic autorecptor
DOPAMINE RECEPTORS
presynaptic autorecptor
dopamine transporter D2 D3 D1 D4 D5
5--33
Stahl S M, Essential Psychopharmacology (2000)

4. serotonin transporter
SEROTONIN RECEPTORS
5HT1D autoreceptor
alpha 2 hetero receptor
serotonin transporter
5HT3
5HT4
5HT2C
5HTX
5HT2A
5HTY
5HT1A
5HTZ
5--36
Stahl S M, Essential Psychopharmacology (2000)

5. SSRI Pharmacological Profile
Powerful 5HT disinhibition in key passways
from midbrain raphe to prefrontal cortex
from midbrain raphe to basal ganglia
from midbrain raphe to limbic cortex and hippocampus
from midbrain raphe to hypothalamus
from midbrain raphe to spinal cord

6. Serotonin Pathways Raphe Nucleus
5--51
Stahl S M, Essential Psychopharmacology (2000)

7. Frontal Cortex Mood Stahl S M, Essential Psychopharmacology (2000)
5--52
Stahl S M, Essential Psychopharmacology (2000)

8. OCD Akathisia/ Agitation Basal Ganglia
5--53
Stahl S M, Essential Psychopharmacology (2000)

9. Limbic
Anxiety
5--54
Stahl S M, Essential Psychopharmacology (2000)

10. Hypothalamus Appetite/bulimia
5--55
Stahl S M, Essential Psychopharmacology (2000)

11. Sleep Centers Insomnia
5--56
Stahl S M, Essential Psychopharmacology (2000)

12. serotonin transporter
SEROTONIN RECEPTORS
5HT1D autoreceptor
alpha 2 hetero receptor
serotonin transporter
5HT3
5HT4
5HT2C
5HTX
5HT2A
5HTY
5HT1A
5HTZ
5--36
Stahl S M, Essential Psychopharmacology (2000)

13. NOREPINEPHRINE RECEPTORS
presynaptic alpha 2 autoreceptor
postsynaptic alpha 2 receptor
alpha 1 receptor
postsynaptic beta 1 receptor
5-19
Stahl S M, Essential Psychopharmacology (2000)

14. norepinephrine neuron
serotonin neuron
postsynaptic alpha 2 hetero receptor
5HT accelerator
5HT brake
presynaptic alpha 2 autoreceptor
alpha 1 receptor
presynaptic alpha 2 autoreceptor
norepinephrine neuron
5--48
Stahl S M, Essential Psychopharmacology (2000)

15. 5HT1A anti- depressant anxiolytic sleep restoring anxiolytic 5HT2A
no sexual dysfunction
5HT2C
anxiolytic
weight gain
5HT3
no GI problems
no nausea
7-11
Stahl S M, Essential Psychopharmacology (2000)

16. H1
TCA
SRI M1
NRI
6-27
Stahl S M, Essential Psychopharmacology (2000)

17. 5-HT1A
Antidepressant
Anxiolytic
Lowering temperature

18. SRI inserted NRI inserted
depression lifts
NRI inserted
depression lifts
Stahl S M, Essential Psychopharmacology (2000)

19. weight gain drowsiness H1 inserted blurred vision constipation
LAXATIVE
constipation
dry mouth
blurred vision
drowsiness
M1 inserted
Stahl S M, Essential Psychopharmacology (2000)

20. decreased blood pressure
dizziness
decreased blood pressure
inserted
6-32
Stahl S M, Essential Psychopharmacology (2000)