7 Granulomatous Prostatitis Cause :Disseminated tuberculosisSarcoidosis.
8 Infarction of prostate Etiology:Post oprtative retention of urine.Prolonged operative hypotensionSmoking and pre-existing cardiovascular disease.Lab: May increase the serum prostate specific antigen.
21 Carcinoma prostate General features Etiopathogenesis PIN Morphology of Prostatic carcinomaDiagnosisGradingManagement
22 Carcinoma of prostate : general features Age : yr.Orchiectomy/ estrogen therapy reduces the tumor size.Migration: Male migrate from a low risk area to high risk area maintain their low risk of cancer.
23 EtiopathogenesisEffect of Androgen ( so, Orchiectomy reduce the tumor size in Prostatic carcinoma patient).Genetic ( Chromosome No 1 and 10).Environmental factors ( common in Scandinavian countries, uncommon in Japan)Diet rich in animal fat.
24 Prostatic intraepithelial Neoplasia Def: A precancerous cellular proliferation found in a single acinus or small group of prostatic acini.
25 Importance of PINThe finding of PIN suggests that Prostatic adenocarcinoma may also be present.
26 Prostatic adenocarcinoma ; Presenting features Clinically silentProstatism : local discomfort and evidence of lower urinary tract obstruction.Bone metastasis : mainly to the axial skeleton ( osteoblastic)
27 Gross of prostate adenocarcinoma ; mostly begin (arises) in the periphery of prostate. Location: posterior lobe.Yellowish nodules
28 High power : back to back arrangement of the malignant glands and cells with prominent nuclei.
30 Diagnosis Digital rectal examination MRI scan X- ray in suspected case of bone metastasis ( osteoblastic).PSA study. ( more than 10 ng/dl)Needle biopsyImmunofluroscence staining by Prostatic specific antigen.
31 Osteoblastic bone lesion in metastasis Prostatic cancer Osteoblastic bone lesion in metastasis Prostatic cancer. Which one is normal ?
32 Self assessment PIN ( micro) Diagnosis of Prostatic carcinoma. Medical management.Prostatic carcinoma ( gross and micro)BPH ( gross and micro)Chronic a-bacterial Prostatitis.