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The apoptosis effect of hispolon from Phellinus linteus (Berkeley & Curtis)Teng on human epidermoid KB cells 任課老師 : 詹于誼 學 生 : 唐若廷 & 陳玉貞 日 期 : 2008 06 10.

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Presentation on theme: "The apoptosis effect of hispolon from Phellinus linteus (Berkeley & Curtis)Teng on human epidermoid KB cells 任課老師 : 詹于誼 學 生 : 唐若廷 & 陳玉貞 日 期 : 2008 06 10."— Presentation transcript:

1 The apoptosis effect of hispolon from Phellinus linteus (Berkeley & Curtis)Teng on human epidermoid KB cells 任課老師 : 詹于誼 學 生 : 唐若廷 & 陳玉貞 日 期 : 2008 06 10 Journal of Ethnopharmacology 105 (2006) 280–285

2 Introduction 桑黃( Phellinus linteus )為一種寄生於闊葉樹上 的刺革菌科菇類,因其生長緩慢,取得不易,加 上難以人工栽培,故有「夢幻菇蕈」之稱。

3 Classification of Phellinus linteus

4 Phellinus linteus(PL) 的成分介紹 Polysaccharides Triterpenoids phenolics Meshimakobnol Proteins Mineral

5 Pharmacological study of Phellinus linteus  Phellinus linteus (PL), a traditional medicinal mushroom, for the treatment of various diseases.  gastroenteric disorder  peptic ulcers  lymphatic disease  various cancers

6  Recent studies have shown that PL has  anti-inflammatory  antimutagenicity  antibacterial effects  stimulates immunity  inhibits tumor growth and metastasis

7 Hispolon 分子結構 : 化學名 : 6-(3,4-dihydroxy-phenyl)-4-hydroxy-hexa- 3,5-dien-2-one 分子式 : C 12 H 12 O 4 分子量 : 220.22  Hispolon,a yellow pigment was first found in Inonotus hispidus in 1996

8 Hispolon, an active polyphenol compound, is known to possess potent induces apoptosis in cancer cells.

9 That hispolon could induce human epidermoid KB cell apoptosis accompanied by the collapse of mitochondrial membrane potential. Hispolon induces apoptosis in cancer cells : treatment of oral cancer

10 the efficacy of hispolon in human gastric cancer cells and explored the cell death mechanism. Hispolon induced ROS-mediated apoptosis in gastric cancer cells. Free Radical Biology & Medicine 45 (2008) 60–72 treatment of gastric cancer

11 antiviral antiproliferative immunomodulatory activity antioxidant activity  Other studies also showed that hispolon has

12 antiviral of Hispolon : hispolon showed considerable antiviral activity against influenza viruses type A and B. Received 8 November 2002; accepted 8 April 2003

13 Hispolon also suppress mitogen induced proliferation of spleen lymphocytes of mice. antiproliferative of Hispolon : Pharmazie. 1996 Sep;51(9):667-70

14 Isolation and purification of hispolon 1.5kg fruiting body of PL 95%EtOH removal of the EtOH under reduced pressure at 40 ◦ C, a dark yellow residue (64.5 g) silica gel column chromatography eight major fractions fraction 3 (3.37 g) silica gel column chromatography reversed-phase HPLC red crystals (65 mg) hispolon Etopside


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