1. oncogene, anti-oncogene and growth factor
The biochemistry and molecular biology department of CMU

2. Relationship of oncogene, anti-oncogene and growth factor

3. §1 Oncogene

4. Oncogenes are cellular genes that can trigger uncontrolled cell proliferation if their sequence is altered or their expression is incorrectly regulated.

5. A gene found in viruses or as part of the normal genome that is involved in triggering cancerous characteristics.
Control the cell growth and cell differentiation.
virus oncogene (v-onc) and cellular- oncogene (c-onc) or proto-oncogene

6. Virus- oncogene (v-onc)
Genes are in viruses that can cause tumors in vivo and transform the cell in vitro.

7. In 1910, Peyton Rous found the first retrovirus in a chickens filtrated sarcoma. Rous got the Nobel Prize in Physiology and Medicine in 1966.

8. Cellular Oncogene (c-onc)
Genes are in static or low-level expression state in normal cells under the normal situation and play an important role in maintaining the normal function of cells.

10. Category and major product of cellular oncogene
1. src family — tyrosine protein kinase
2. ras familiy — P21（GTPase activity）
3. myc familiy — intranuclear DNA binding protein
4. sis familiy — P28 (similar platelet derived growth factor)
5. myb familiy — intranuclear transcription factor

11. Product and Function of Proto-oncogene
Extracellular growth factors
Transmembrane growth factor receptors
Intracellular signal transduction proteins
Intranuclear transcription factors

14. Mechanisms of Oncogene Activation
Obtaining promoter or enhancer
Group translocation or chromosome rearrangements
Proto-oncogene amplification
Gene mutation

19. familiar human growth factor
Principal resource
Primary function
EGF
Submaxillary gland, kidney, duodenal gland
EPO
HGF
Placenta
kidney
IFN- γ
Activated TH1 and NK cells
IGF
Placent, primarily liver, plasm
NGF
Neur, submaxillary gland
PDGF
Platelets,endothelial cells,placenta
TGFα
Tumor cell, transforming cell, placenta
TGFβ
Activated TH1 cells(T-helper) and
natural killer(NK) cells
VEGF
Smooth muscle, tumor