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(a) Reproduction (b) Growth and development (c) Tissue renewal 100 µm

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Presentation on theme: "(a) Reproduction (b) Growth and development (c) Tissue renewal 100 µm"— Presentation transcript:

1 (a) Reproduction (b) Growth and development (c) Tissue renewal 100 µm

2 20 µm

3 0.5 µm Chromosomes DNA molecules Chromo- some arm Chromosome duplication (including DNA synthesis) Centromere Sister chromatids Separation of sister chromatids Centromere Sister chromatids

4 Chromosome, consisting of two sister chromatids
G2 of Interphase Prophase Prometaphase Metaphase Anaphase Telophase and Cytokinesis Centrosomes (with centriole pairs) Chromatin (duplicated) Early mitotic spindle Aster Centromere Fragments of nuclear envelope Nonkinetochore microtubules Metaphase plate Cleavage furrow Nucleolus forming Daughter chromosomes Nuclear envelope forming Nucleolus Nuclear envelope Plasma membrane Chromosome, consisting of two sister chromatids Kinetochore Kinetochore microtubule Spindle Centrosome at one spindle pole

5 5 µm Pair of homologous replicated chromosomes Centromere Sister chromatids Metaphase chromosome

6 Key Maternal set of chromosomes (n = 3) 2n = 6 Paternal set of chromosomes (n = 3) Two sister chromatids of one replicated chromosome Centromere Two nonsister chromatids in a homologous pair Pair of homologous chromosomes (one from each set)

7 Key Haploid gametes (n = 23) Haploid (n) Egg (n) Diploid (2n) Sperm (n) MEIOSIS FERTILIZATION Ovary Testis Diploid zygote (2n = 46) Mitosis and development Multicellular diploid adults (2n = 46)

8 Key Haploid (n) Haploid unicellular or multicellular organism Diploid (2n) Haploid multi- cellular organism (gametophyte) n Gametes n n Mitosis n Mitosis Mitosis n Mitosis n n n n n MEIOSIS FERTILIZATION Spores n Gametes n Gametes n MEIOSIS FERTILIZATION Zygote MEIOSIS FERTILIZATION 2n 2n 2n 2n Diploid multicellular organism Zygote Diploid multicellular organism (sporophyte) 2n Mitosis Mitosis Zygote (a) Animals (b) Plants and some algae (c) Most fungi and some protists

9 Homologous pair of chromosomes in diploid parent cell
Interphase Homologous pair of chromosomes in diploid parent cell Chromosomes replicate Homologous pair of replicated chromosomes Sister chromatids Diploid cell with replicated chromosomes Meiosis I 1 Homologous chromosomes separate Haploid cells with replicated chromosomes Meiosis II 2 Sister chromatids separate Haploid cells with unreplicated chromosomes

10 Prophase I Metaphase I Anaphase I Telophase I and Cytokinesis Prophase II Metaphase II Anaphase II Telophase II and Cytokinesis Centrosome (with centriole pair) Sister chromatids remain attached Centromere (with kinetochore) Sister chromatids Chiasmata Spindle Metaphase plate Sister chromatids separate Haploid daughter cells forming Homologous chromosomes Homologous chromosomes separate Cleavage furrow Fragments of nuclear envelope Microtubule attached to kinetochore

11 MITOSIS MEIOSIS MEIOSIS I Parent cell Chiasma Chromosome replication Chromosome replication Prophase I Prophase Homologous chromosome pair 2n = 6 Replicated chromosome Metaphase Metaphase I Anaphase Telophase Anaphase I Telophase I Haploid n = 3 Daughter cells of meiosis I 2n 2n MEIOSIS II Daughter cells of mitosis n n n n Daughter cells of meiosis II

12 Possibility 1 Possibility 2 Two equally probable arrangements of chromosomes at metaphase I Metaphase II Daughter cells Combination 1 Combination 2 Combination 3 Combination 4

13 Recombinant chromosomes
Prophase I of meiosis Nonsister chromatids held together during synapsis Pair of homologs Chiasma Centromere TEM Anaphase I Anaphase II Daughter cells Recombinant chromosomes

14 Meiosis I Meiosis II Gametes (a) Nondisjunction of homologous
Number of chromosomes (a) Nondisjunction of homologous chromosomes in meiosis I (b) Nondisjunction of sister chromatids in meiosis II


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