1. S ystolic H eart failure treatment with the I f inhibitor ivabradine T rial Selective heart rate reduction with ivabradine unloads the left ventricle in heart failure patients www.shift-study.comReil JC, et al. J Am Coll Cardiol. 2013 Nov 19;62(21):1977-1985

2. Effect of HR reduction with ivabradine on stroke volume and cardiac output in patients with systolic HF Stroke volume, ml Cardiac output, ml/min P =0.31P <0.01 P <0.0001 www.shift-study.comReil JC, et al. J Am Coll Cardiol. 2013 Nov 19;62(21):1977-1985 Baseline Month 8 n=275 Procoralan maintains cardiac output. Procoralan increases stroke volume.

3. Ivabradine has no impact on blood pressure even in the long term www.shift-study.comReil JC, et al. J Am Coll Cardiol. 2013 Nov 19;62(21):1977-1985 Baseline Month 8 Blood pressure (mmHg) NS n=275