1. Available and Ongoing Clinical Trials for Parkinson’s Disease Patients

2. EARLY PD Rasagiline – may slow progression of PD Rasagiline – may slow progression of PD In a preliminary delayed start study those who took rasagiline from the beginning did better than those who started it after 6 months In a preliminary delayed start study those who took rasagiline from the beginning did better than those who started it after 6 months Istradefylline – may improve PD symptoms without causing dyskinesia Istradefylline – may improve PD symptoms without causing dyskinesia

3. EARLY PD STRIDE and FIRST STEP – evaluate Stalevo vs. Sinemet with regard to: STRIDE and FIRST STEP – evaluate Stalevo vs. Sinemet with regard to: Does Stalevo improve PD more than Sinemet? Does Stalevo improve PD more than Sinemet? Does Stalevo cause less dyskinesia? Does Stalevo cause less dyskinesia? Does Stalevo lower homocysteine? Elevations of homocysteine may cause strokes and be associated with dementia Does Stalevo lower homocysteine? Elevations of homocysteine may cause strokes and be associated with dementia CoQ10 CoQ10 May slow progression of disease May slow progression of disease Stabilizes energy production in cells Stabilizes energy production in cells

4. MODERATE PD Glutathione – antioxidant Glutathione – antioxidant May improve symptoms May improve symptoms May slow progression May slow progression Eye Safety Study Eye Safety Study Tests eyesight while taking Parkinson Disease medications Tests eyesight while taking Parkinson Disease medications

5. ADVANCED PD Istradefylline – for patients with fluctuations Istradefylline – for patients with fluctuations Spheramine – transplantation of retinal cells Spheramine – transplantation of retinal cells These cells make levodopa and serve as levodopa pumps in the brain These cells make levodopa and serve as levodopa pumps in the brain for pts with moderate – severe symptoms in the morning before taking medication for pts with moderate – severe symptoms in the morning before taking medication Sarizotan – for dyskinesia Sarizotan – for dyskinesia

6. OTHER Fatigue Study Fatigue Study Try to understand and treat potential causes of fatigue in PD Try to understand and treat potential causes of fatigue in PD Psychosis Study Psychosis Study Evaluating the use of Melperone (an antipsychotic) in PD patients with psychosis Evaluating the use of Melperone (an antipsychotic) in PD patients with psychosis SPECT scan studies SPECT scan studies Develop a scan as a diagnostic tool to discern between Parkinsonian and non-Parkinsonian tremor Develop a scan as a diagnostic tool to discern between Parkinsonian and non-Parkinsonian tremor

7. If interested in clinical trials, please call: 813-844-4455or813-974-5909