1. http://www.youtube.com/watch ?v=pQO3Tq3KQL4 http://www.youtube.com/watch?v=NWMOmB ohlTE

3. 11/6/1906, presenile dementia ; amyloid plaques and neurofibrillary tanglesamyloid neurofibrillary tangles Auguste Deter Alzheimer’s Disease

5. Hippocampus CA: cornu ammonis (horn shape) Alzheimer’s disease

6.  -amyloid precursor protein (APP) and its principal metabolic derivatives

7. Treatment for Alzheimer’s Disease Designed helical peptide inhibitor of  and/or  -secretase

8. 2D-SDS-PAGE kDa 250 150 100 75 50 37 25 20 5 pH 7 A B C D EF G H Vision Research Lab: Srinivas Sripathi/Welue He/Cameron Atkinson