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Enrollment, Randomization, and Follow-up of Study Participants ADVANCE Collaborative Group. N Engl J Med 2008;358:2560-72.

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Presentation on theme: "Enrollment, Randomization, and Follow-up of Study Participants ADVANCE Collaborative Group. N Engl J Med 2008;358:2560-72."— Presentation transcript:

1 Enrollment, Randomization, and Follow-up of Study Participants ADVANCE Collaborative Group. N Engl J Med 2008;358:2560-72

2 Baseline Personal Characteristics Stratified by Sex in Relation to Diabetes Mellitus and a Prior MI - Part I Tina Ken Schramm, et al. Circulation 2008;117:1945-1954

3 Baseline Personal Characteristics Stratified by Sex in Relation to Diabetes Mellitus and a Prior MI - Part II Tina Ken Schramm, et al. Circulation 2008;117:1945-1954

4 Numbers of Events During the Study Period (1997-2002) for Different End Points Stratified by Sex in Relation to Diabetes Mellitus and a Prior MI Tina Ken Schramm, et al. Circulation 2008;117:1945-1954

5 Age- and Multivariable-Adjusted Cox Multivariable Proportional-Hazard Analysis Stratified by Sex Demonstrating Relative Hazards for Different End Points in Relation to Diabetes Mellitus and a Prior MI Tina Ken Schramm, et al. Circulation 2008;117:1945-1954

6 Event rates for cardiovascular mortality in men (A) and women (B) stratified by age and sex in relation to diabetes mellitus (DM) and a prior MI Tina Ken Schramm, et al. Circulation 2008;117:1945-1954

7 Event rates for the composite end point of MI (nonfatal), stroke (nonfatal), and cardiovascular death in men (A) and women (B) stratified by age in relation to diabetes mellitus (DM) and a prior MI Tina Ken Schramm, et al. Circulation 2008;117:1945-1954

8 Secular trends for medical treatment in percentage during follow-up in relation to diabetes mellitus and a prior MI. ACE indicates angiotensin-converting enzyme; ARB, angiotensin receptor blocker Tina Ken Schramm, et al. Circulation 2008;117:1945-1954

9 Age-adjusted Cox multivariable proportional-hazard analysis stratified by sex demonstrating secular trends in relative risks (RR) for different end points in relation to diabetes mellitus and a prior MI, with nondiabetics without a prior MI as the reference Tina Ken Schramm, et al. Circulation 2008;117:1945-1954

10 CLINICAL PERSPECTIVE Tina Ken Schramm, et al. Circulation 2008;117:1945-1954


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